A3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Ovis aries

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YH2

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-024-53473-1

PUBLICATION DATE

Nov. 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

34 interactions (Click to see)

LIGANDS

adenosine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 116 34x51 G.H5 T 340 G.H5.12
Polar ICL2 T 115 34x50 G.H5 N 347 G.H5.19
Polar TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 207 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 112 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 47 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 47 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL4 K 284 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 K 284 - G.H5 G 352 G.H5.24
Hydrophobic TM5 I 203 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 203 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM7 I 285 7x57 G.H5 D 350 G.H5.22
Van-der-waals TM7 I 285 7x57 G.H5 D 350 G.H5.22
Polar ICL2 R 119 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 206 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 206 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 119 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 207 5x69 G.H5 K 345 G.H5.17
Hydrophobic ICL2 Y 118 34x53 G.H5 N 347 G.H5.19
Ionic TM5 R 206 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 206 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 206 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 206 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Ionic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM7 I 285 7x57 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 I 285 7x57 G.H5 C 351 G.H5.23
Van-der-waals TM7 I 285 7x57 G.H5 C 351 G.H5.23
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Polar TM6 T 227 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 227 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 227 6x33 G.H5 L 353 G.H5.25
Ionic TM3 R 111 3x53 G.H5 D 350 G.H5.22
Polar TM2 T 45 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 231 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 231 6x37 G.H5 L 353 G.H5.25
Ionic H8 K 287 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25