PDB
8YH2
Resolution
3.3 Å
Released
Nov. 6, 2024
Receptor
A3
Class
A
Species
Ovis aries
Ligand
adenosine
Function
Agonist
Reference
10.1038/S41467-024-53473-1

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Ligand Amino Acid Generic Number Segment Interaction Type
adenosine M90 3.32x32 TM3 polar (hydrogen bond)
adenosine L91 3.33x33 TM3 Van der Waals
adenosine T94 3.36x36 TM3 Van der Waals
adenosine F167 45.52x52 ECL2 Van der Waals
adenosine F167 45.52x52 ECL2 aromatic (face-to-face)
adenosine M176 ECL2 Van der Waals
adenosine L245 6.51x51 TM6 Van der Waals
adenosine L245 6.51x51 TM6 hydrophobic
adenosine N249 6.55x55 TM6 polar (hydrogen bond)
adenosine N249 6.55x55 TM6 polar (hydrogen bond)
adenosine N249 6.55x55 TM6 Van der Waals
adenosine L263 7.35x34 TM7 Van der Waals
adenosine I267 7.39x38 TM7 hydrophobic
adenosine I267 7.39x38 TM7 Van der Waals
adenosine H271 7.43x42 TM7 polar (hydrogen bond)
adenosine H271 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S L Q ICL1ECL1 V T I ECL1ICL2 T V R Y R R V T ICL2ECL2 W N M K L S S A D E N L T F L P C R F R S V M R M D Y M V Y F ECL2ECL3 D G Q V ECL3N-term M P V N S T A V N-termC-term Q P S K S M D P S T E Q T S E C-term S W T S V T Y I T V E I L I G L C A I V G N V L V I W V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V I S L G H F Y S C L F M T C L M L I F T H A S I M S L L A I A V D R Y L R V K L T Q R R I W L A L G L C W L V S F L V G L T P M F G S F F L W I L V P L V V M C A I Y F D I F Y I I R N R L S Q S F S G S R E T G A F Y G R E F K T A K S L L L V L F L F A L C W L P L S I I N C I L Y F P Q T V L Y L G I L L S H A N S M M N P I V Y A Y K I K K F L L I V M C K E T Y L K A C
Helix box plot — Download: PNG | SVG V N G V I A C L G I L I E V T I Y T V S 1 V S L A L A D I A V G L V V M P L A I V I 2 A L L S M I S A H T F I L M L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P V L I W L F F S 5 L L V L F L F A L C W L P L S I I N C I 6 I P N M M S N A H S L L I G L Y L V T 7

GPCRdb(A)
GPCRdb(A)
A3 receptor
TM3
3x32 3.32x32 M90
3x33 3.33x33 L91
3x36 3.36x36 T94
ECL2
45x52 45.52x52 F167
TM6
6x51 6.51x51 L245
6x55 6.55x55 N249
TM7
7x34 7.35x34 L263
7x38 7.39x38 I267
7x42 7.43x42 H271