Refined structure (8IBV) of Gq - motilin receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (59.9%), 144 from model (40.1%)
Residue sidechains - 114 from structure (31.8%), 245 from model (68.2%)

REFINED GPCR RESIDUES

Residue backbones - 279 from structure (72.7%), 105 from model (27.3%)
Residue sidechains - 279 from structure (72.7%), 105 from model (27.3%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
A01R02G.hns1E01G.S1N19Y23N24G.H5GproteinA3x53R3x50R34x54GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S1G.H5GPCR segments:ICL2TM3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x402x433x493x503x533x5434x5034x5134x5434x555x655x726x306x326x336x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.16G.H5.15G.H5.06G.S6.04G.h4s6.20G.H4.16G.S3.01G.S1.02G.S1.01G.hns1.03G.hns1.02G.hns1.01G.HN.52Res. Pos.motilin (8IBV_REFINED)- (8IBV_REFINED)--------------------TNLERAIPLRVLLHQTLSKTNLPLRVERAILLHQTLSKPYNINVELARRRLLLFHVVI

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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