TAS2R16 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

April 2, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

salicin - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM5 H 210 5x72 G.H5 T 235 G.H5.12
Hydrophobic TM6 A 225 6x34 G.H5 L 243 G.H5.20
Polar TM6 C 215 6x24 G.H5 D 236 G.H5.13
Hydrophobic TM6 S 218 6x27 G.H5 K 240 G.H5.17
Van-der-waals TM6 S 218 6x27 G.H5 K 240 G.H5.17
Hydrophobic TM4 R 124 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM3 Y 103 3x50 G.H5 L 248 G.H5.25
Hydrophobic ICL2 W 120 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 W 120 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 V 107 - G.H5 I 239 G.H5.16
Hydrophobic TM3 K 106 3x53 G.H5 C 246 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 C 246 G.H5.23
Hydrophobic TM5 H 210 5x72 G.H5 D 232 G.H5.09
Ionic TM6 R 222 6x31 G.H5 D 236 G.H5.13
Polar TM6 R 222 6x31 G.H5 D 236 G.H5.13
Hydrophobic TM6 R 222 6x31 G.H5 D 236 G.H5.13
Hydrophobic TM3 Y 103 3x50 G.H5 C 246 G.H5.23
Polar TM3 K 106 3x53 G.H5 N 242 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 242 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 242 G.H5.19
Polar TM6 S 218 6x27 G.H5 D 236 G.H5.13
Hydrophobic TM6 S 218 6x27 G.H5 D 236 G.H5.13
Van-der-waals TM6 S 218 6x27 G.H5 D 236 G.H5.13
Hydrophobic TM6 T 224 6x33 G.H5 F 249 G.H5.26
Hydrophobic ICL2 V 107 - G.H5 N 242 G.H5.19
Van-der-waals TM2 V 45 2x39 G.H5 C 246 G.H5.23
Hydrophobic ICL2 W 120 - G.HN K 34 G.HN.51
Van-der-waals ICL2 W 120 - G.HN K 34 G.HN.51
Hydrophobic TM2 M 43 2x37 G.H5 D 245 G.H5.22
Van-der-waals TM2 M 43 2x37 G.H5 D 245 G.H5.22
Hydrophobic ICL2 V 107 - G.H5 C 246 G.H5.23
Hydrophobic TM6 A 221 6x30 G.H5 L 243 G.H5.20
Hydrophobic TM6 A 221 6x30 G.H5 K 240 G.H5.17
Hydrophobic TM5 Q 206 5x68 G.H5 I 239 G.H5.16
Hydrophobic TM6 A 221 6x30 G.H5 F 249 G.H5.26
Van-der-waals TM6 A 221 6x30 G.H5 F 249 G.H5.26
Hydrophobic ICL2 V 107 - G.H5 L 243 G.H5.20
Van-der-waals ICL2 V 107 - G.H5 L 243 G.H5.20
Hydrophobic TM6 P 217 6x26 G.H5 K 240 G.H5.17
Van-der-waals TM6 P 217 6x26 G.H5 K 240 G.H5.17
Hydrophobic TM6 R 222 6x31 G.H5 I 239 G.H5.16
Van-der-waals TM6 R 222 6x31 G.H5 I 239 G.H5.16
Ionic TM3 K 106 3x53 G.H5 D 245 G.H5.22
Polar TM3 K 106 3x53 G.H5 D 245 G.H5.22
Hydrophobic TM3 K 106 3x53 G.H5 D 245 G.H5.22
Van-der-waals TM3 K 106 3x53 G.H5 D 245 G.H5.22
Polar TM6 A 225 6x34 G.H5 L 248 G.H5.25
Hydrophobic TM6 A 225 6x34 G.H5 L 248 G.H5.25
Van-der-waals TM6 A 225 6x34 G.H5 L 248 G.H5.25