PDB
9KPD
Resolution
2.8 Å
Released
April 2, 2025
Receptor
TAS2R16
Class
T2
Species
Homo sapiens
Ligand
salicin
Function
Agonist
Reference
10.1016/J.CELREP.2025.115604

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Ligand Amino Acid Generic Number Segment Interaction Type
salicin W85 3.32x32 TM3 hydrophobic
salicin I247 6.56x56 TM6 hydrophobic
salicin K254 ECL3 polar (charge-assisted hydrogen bond)
salicin E262 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R L ICL1ECL1 L N Y ECL1ICL2 S F T H H I F L W L R W ICL2ECL2 I Q I Q L L T M E H L P R N S T V T D K L E N F H Q Y ECL2ICL3 C ICL3ECL3 D K ECL3N-term M I N-term P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S R I L R L F P W I L L G S L M I T C V T I I P S A I G N Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K G L K R I K C
Helix box plot — Download: PNG | SVG S S Q V I I T L S E L V Y I I M F F V T 1 I S L G I S R F C L Q W A S M L N N F C 2 L S N L W F T L I N F F E W T I T L N C 3 F P W I L L G S L M I T C V T I I P S A 4 T S A L F L I F P I V L A V T H A Q F Q 5 L A V L F I V F T S Y F L T I L I T I I 6 T S H M L I F A Y V F A E W V W L W C 7

GPCRdb(A)
GPCRdb(A)
TAS2R16
TM3
3x32 3.32x32 W85
TM6
6x56 6.56x56 I247
TM7
7x38 7.39x38 E262