Refined structure (7CX4) of Gs - EP2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 228 from structure (57.9%), 166 from model (42.1%)
Residue sidechains - 214 from structure (54.3%), 180 from model (45.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure AF2
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure AF2
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure AF2
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 261 from structure (77.0%), 78 from model (23.0%)
Residue sidechains - 242 from structure (71.4%), 97 from model (28.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 D - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 Q - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 D - AF2 AF2
N-term 13 C - AF2 AF2
N-term 14 E - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 R - AF2 AF2
N-term 17 Q - AF2 AF2
N-term 18 W - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 E - AF2 AF2
TM1 24 S 1.35x35 AF2 AF2
TM1 25 P 1.36x36 AF2 AF2
TM1 26 A 1.37x37 AF2 AF2
TM1 27 I 1.38x38 Structure Structure
TM1 28 S 1.39x39 Structure Structure
TM1 29 S 1.40x40 Structure Structure
TM1 30 V 1.41x41 Structure Structure
TM1 31 M 1.42x42 Structure Structure
TM1 32 F 1.43x43 Structure Structure
TM1 33 S 1.44x44 Structure Structure
TM1 34 A 1.45x45 Structure Structure
TM1 35 G 1.46x46 Structure Structure
TM1 36 V 1.47x47 Structure Structure
TM1 37 L 1.48x48 Structure Structure
TM1 38 G 1.49x49 Structure Structure
TM1 39 N 1.50x50 Structure Structure
TM1 40 L 1.51x51 Structure Structure
TM1 41 I 1.52x52 Structure Structure
TM1 42 A 1.53x53 Structure Structure
TM1 43 L 1.54x54 Structure Structure
TM1 44 A 1.55x55 Structure Structure
TM1 45 L 1.56x56 Structure Structure
TM1 46 L 1.57x57 Structure Structure
TM1 47 A 1.58x58 Structure Structure
TM1 48 R 1.59x59 Structure Structure
TM1 49 R 1.60x60 AF2 AF2
ICL1 50 W - AF2 AF2
ICL1 51 R - AF2 AF2
ICL1 52 G - AF2 AF2
ICL1 53 D - AF2 AF2
ICL1 54 V - AF2 AF2
ICL1 55 G - AF2 AF2
ICL1 56 C - AF2 AF2
ICL1 57 S - AF2 AF2
ICL1 58 A - AF2 AF2
ICL1 59 G - AF2 AF2
ICL1 60 R - AF2 AF2
ICL1 61 R - AF2 AF2
ICL1 62 S - AF2 AF2
ICL1 63 S - AF2 AF2
ICL1 64 L - AF2 AF2
TM2 65 S 2.37x37 Structure Structure
TM2 66 L 2.38x38 Structure Structure
TM2 67 F 2.39x39 Structure Structure
TM2 68 H 2.40x40 Structure Structure
TM2 69 V 2.41x41 Structure Structure
TM2 70 L 2.42x42 Structure Structure
TM2 71 V 2.43x43 Structure Structure
TM2 72 T 2.44x44 Structure Structure
TM2 73 E 2.45x45 Structure Structure
TM2 74 L 2.46x46 Structure Structure
TM2 75 V 2.47x47 Structure Structure
TM2 76 F 2.48x48 Structure Structure
TM2 77 T 2.49x49 Structure Structure
TM2 78 D 2.50x50 Structure Structure
TM2 79 L 2.51x51 Structure Structure
TM2 80 L 2.52x52 Structure Structure
TM2 81 G 2.53x53 Structure Structure
TM2 82 T 2.54x54 Structure Structure
TM2 83 C 2.55x55 Structure Structure
TM2 84 L 2.56x56 Structure Structure
TM2 85 I 2.57x57 Structure Structure
TM2 86 S 2.58x58 Structure Structure
TM2 87 P 2.59x59 Structure Structure
TM2 88 V 2.60x60 Structure Structure
TM2 89 V 2.61x61 Structure Structure
TM2 90 L 2.62x62 Structure Structure
TM2 91 A 2.63x63 Structure Structure
TM2 92 S 2.64x64 Structure Structure
TM2 93 Y 2.65x65 Structure Structure
TM2 94 A 2.66x66 Structure Structure
TM2 95 R 2.67x67 Structure AF2
TM2 96 N 2.68x68 Structure AF2
ECL1 97 Q - Structure AF2
ECL1 98 T - Structure Structure
ECL1 99 L - Structure AF2
ECL1 100 V - Structure AF2
ECL1 101 A - Structure Structure
ECL1 102 L - Structure Structure
ECL1 103 A - Structure Structure
ECL1 104 P - Structure Structure
ECL1 105 E - Structure Structure
TM3 106 S 3.22x22 Structure Structure
TM3 107 R 3.23x23 Structure Structure
TM3 108 A 3.24x24 Structure Structure
TM3 109 C 3.25x25 Structure Structure
TM3 110 T 3.26x26 Structure Structure
TM3 111 Y 3.27x27 Structure Structure
TM3 112 F 3.28x28 Structure Structure
TM3 113 A 3.29x29 Structure Structure
TM3 114 F 3.30x30 Structure Structure
TM3 115 A 3.31x31 Structure Structure
TM3 116 M 3.32x32 Structure Structure
TM3 117 T 3.33x33 Structure Structure
TM3 118 F 3.34x34 Structure Structure
TM3 119 F 3.35x35 Structure Structure
TM3 120 S 3.36x36 Structure Structure
TM3 121 L 3.37x37 Structure Structure
TM3 122 A 3.38x38 Structure Structure
TM3 123 T 3.39x39 Structure Structure
TM3 124 M 3.40x40 Structure Structure
TM3 125 L 3.41x41 Structure Structure
TM3 126 M 3.42x42 Structure Structure
TM3 127 L 3.43x43 Structure Structure
TM3 128 F 3.44x44 Structure Structure
TM3 129 A 3.45x45 Structure Structure
TM3 130 M 3.46x46 Structure Structure
TM3 131 A 3.47x47 Structure Structure
TM3 132 L 3.48x48 Structure Structure
TM3 133 E 3.49x49 Structure Structure
TM3 134 R 3.50x50 Structure Structure
TM3 135 Y 3.51x51 Structure Structure
TM3 136 L 3.52x52 Structure Structure
TM3 137 S 3.53x53 Structure Structure
TM3 138 I 3.54x54 Structure Structure
TM3 139 G 3.55x55 Structure Structure
TM3 140 H 3.56x56 Structure Structure
ICL2 141 P 34.50x50 Structure Structure
ICL2 142 Y 34.51x51 Structure Structure
ICL2 143 F 34.52x52 Structure Structure
ICL2 144 Y 34.53x53 Structure Structure
ICL2 145 Q 34.54x54 Structure Structure
ICL2 146 R 34.55x55 Structure Structure
ICL2 147 R 34.56x56 Structure Structure
ICL2 148 V 34.57x57 Structure Structure
TM4 149 S 4.38x38 Structure Structure
TM4 150 R 4.39x39 Structure Structure
TM4 151 S 4.40x40 Structure Structure
TM4 152 G 4.41x41 Structure Structure
TM4 153 G 4.42x42 Structure Structure
TM4 154 L 4.43x43 Structure Structure
TM4 155 A 4.44x44 Structure Structure
TM4 156 V 4.45x45 Structure Structure
TM4 157 L 4.46x46 Structure Structure
TM4 158 P 4.47x47 Structure Structure
TM4 159 V 4.48x48 Structure Structure
TM4 160 I 4.49x49 Structure Structure
TM4 161 Y 4.50x50 Structure Structure
TM4 162 A 4.51x51 Structure Structure
TM4 163 V 4.52x52 Structure Structure
TM4 164 S 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 L 4.55x55 Structure Structure
TM4 167 F 4.56x56 Structure Structure
TM4 168 C 4.57x57 Structure Structure
TM4 169 S 4.58x58 Structure Structure
TM4 170 L 4.59x59 Structure Structure
TM4 171 P 4.60x60 Structure Structure
TM4 172 L 4.61x61 Structure Structure
TM4 173 L 4.62x62 Structure Structure
TM4 174 D 4.63x63 Structure Structure
ECL2 175 Y - Structure Structure
ECL2 176 G - Structure Structure
ECL2 177 Q - Structure Structure
ECL2 178 Y - Structure Structure
ECL2 179 V - Structure Structure
ECL2 180 Q - Structure Structure
ECL2 181 Y - Structure Structure
ECL2 182 C - Structure Structure
ECL2 183 P - Structure Structure
ECL2 184 G - Structure Structure
ECL2 185 T - Structure Structure
ECL2 186 W - Structure Structure
ECL2 187 C 45.50x50 Structure Structure
ECL2 188 F 45.51x51 Structure Structure
ECL2 189 I 45.52x52 Structure Structure
ECL2 190 R - Structure Structure
ECL2 191 H - Structure Structure
ECL2 192 G - Structure Structure
ECL2 193 R - Structure AF2
TM5 194 T 5.35x35 Structure Structure
TM5 195 A 5.36x36 Structure Structure
TM5 196 Y 5.37x37 Structure Structure
TM5 197 L 5.38x38 Structure Structure
TM5 198 Q 5.39x39 Structure Structure
TM5 199 L 5.40x40 Structure Structure
TM5 200 Y 5.41x41 Structure Structure
TM5 201 A 5.42x42 Structure Structure
TM5 202 T 5.43x43 Structure Structure
TM5 203 L 5.44x44 Structure Structure
TM5 204 L 5.45x45 Structure Structure
TM5 205 L 5.46x46 Structure Structure
TM5 206 L 5.47x47 Structure Structure
TM5 207 L 5.48x48 Structure Structure
TM5 208 I 5.49x49 Structure Structure
TM5 209 V 5.50x50 Structure Structure
TM5 210 S 5.51x51 Structure Structure
TM5 211 V 5.52x52 Structure Structure
TM5 212 L 5.53x53 Structure Structure
TM5 213 A 5.54x54 Structure Structure
TM5 214 C 5.55x55 Structure Structure
TM5 215 N 5.56x56 Structure Structure
TM5 216 F 5.57x57 Structure Structure
TM5 217 S 5.58x58 Structure Structure
TM5 218 V 5.59x59 Structure Structure
TM5 219 I 5.60x60 Structure Structure
TM5 220 L 5.61x61 Structure Structure
TM5 221 N 5.62x62 Structure Structure
TM5 222 L 5.63x63 Structure Structure
TM5 223 I 5.64x64 Structure Structure
TM5 224 R 5.65x65 Structure Structure
TM5 225 M 5.66x66 Structure Structure
TM5 226 H 5.67x67 Structure Structure
TM5 227 R 5.68x68 Structure AF2
TM5 228 R 5.69x69 Structure AF2
TM5 229 S 5.70x70 Structure Structure
TM5 230 R 5.71x71 AF2 AF2
TM5 231 R 5.72x72 AF2 AF2
TM5 232 S 5.73x73 AF2 AF2
TM5 233 R 5.74x74 AF2 AF2
TM5 234 C 5.75x75 AF2 AF2
TM5 235 G 5.76x76 AF2 AF2
ICL3 236 P - AF2 AF2
ICL3 237 S - AF2 AF2
ICL3 238 L - AF2 AF2
ICL3 239 G - AF2 AF2
ICL3 240 S - AF2 AF2
ICL3 241 G - AF2 AF2
ICL3 242 R - AF2 AF2
ICL3 246 G - AF2 AF2
ICL3 247 A - AF2 AF2
ICL3 248 R - AF2 AF2
ICL3 249 R - AF2 AF2
ICL3 250 R - AF2 AF2
ICL3 251 G - AF2 AF2
ICL3 252 E - AF2 AF2
TM6 253 R 6.24x24 AF2 AF2
TM6 254 V 6.25x25 AF2 AF2
TM6 255 S 6.26x26 AF2 AF2
TM6 256 M 6.27x27 AF2 AF2
TM6 257 A 6.28x28 Structure Structure
TM6 258 E 6.29x29 Structure Structure
TM6 259 E 6.30x30 Structure Structure
TM6 260 T 6.31x31 Structure Structure
TM6 261 D 6.32x32 Structure Structure
TM6 262 H 6.33x33 Structure Structure
TM6 263 L 6.34x34 Structure Structure
TM6 264 I 6.35x35 Structure Structure
TM6 265 L 6.36x36 Structure Structure
TM6 266 L 6.37x37 Structure Structure
TM6 267 A 6.38x38 Structure Structure
TM6 268 I 6.39x39 Structure Structure
TM6 269 M 6.40x40 Structure Structure
TM6 270 T 6.41x41 Structure Structure
TM6 271 I 6.42x42 Structure Structure
TM6 272 T 6.43x43 Structure Structure
TM6 273 F 6.44x44 Structure Structure
TM6 274 A 6.45x45 Structure Structure
TM6 275 V 6.46x46 Structure Structure
TM6 276 C 6.47x47 Structure Structure
TM6 277 S 6.48x48 Structure Structure
TM6 278 L 6.49x49 Structure Structure
TM6 279 P 6.50x50 Structure Structure
TM6 280 F 6.51x51 Structure Structure
TM6 281 T 6.52x52 Structure Structure
TM6 282 I 6.53x53 Structure Structure
TM6 283 F 6.54x54 Structure Structure
TM6 284 A 6.55x55 Structure Structure
TM6 285 Y 6.56x56 Structure Structure
TM6 286 M 6.57x57 Structure Structure
ECL3 287 N - Structure AF2
ECL3 288 E - Structure AF2
ECL3 289 T - Structure Structure
ECL3 290 S - Structure Structure
ECL3 291 S - Structure Structure
ECL3 292 R - Structure AF2
ECL3 293 K - Structure AF2
ECL3 294 E - Structure AF2
ECL3 295 K - Structure AF2
TM7 296 W 7.34x33 Structure Structure
TM7 297 D 7.35x34 Structure Structure
TM7 298 L 7.36x35 Structure Structure
TM7 299 Q 7.37x36 Structure Structure
TM7 300 A 7.38x37 Structure Structure
TM7 301 L 7.39x38 Structure Structure
TM7 302 R 7.40x39 Structure Structure
TM7 303 F 7.41x40 Structure Structure
TM7 304 L 7.42x41 Structure Structure
TM7 305 S 7.43x42 Structure Structure
TM7 306 I 7.44x43 Structure Structure
TM7 307 N 7.45x45 Structure Structure
TM7 308 S 7.46x46 Structure Structure
TM7 309 I 7.47x47 Structure Structure
TM7 310 I 7.48x48 Structure Structure
TM7 311 D 7.49x49 Structure Structure
TM7 312 P 7.50x50 Structure Structure
TM7 313 W 7.51x51 Structure Structure
TM7 314 V 7.52x52 Structure Structure
TM7 315 F 7.53x53 Structure Structure
TM7 316 A 7.54x54 Structure Structure
TM7 317 I 7.55x55 Structure Structure
TM7 318 L 7.56x56 Structure Structure
H8 319 R 8.47x47 Structure Structure
H8 320 P 8.48x48 Structure Structure
H8 321 P 8.49x49 Structure Structure
H8 322 V 8.50x50 Structure Structure
H8 323 L 8.51x51 Structure Structure
H8 324 R 8.52x52 Structure AF2
H8 325 L 8.53x53 Structure Structure
H8 326 M 8.54x54 Structure AF2
H8 327 R 8.55x55 Structure AF2
H8 328 S 8.56x56 Structure Structure
H8 329 V 8.57x57 Structure AF2
H8 330 L 8.58x58 Structure AF2
H8 331 C 8.59x59 AF2 AF2
H8 332 C 8.60x60 AF2 AF2
C-term 333 R - AF2 AF2
C-term 334 I - AF2 AF2
C-term 335 S - AF2 AF2
C-term 336 L - AF2 AF2
C-term 337 R - AF2 AF2
C-term 338 T - AF2 AF2
C-term 339 Q - AF2 AF2
C-term 340 D - AF2 AF2
C-term 341 A - AF2 AF2
C-term 342 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Polar TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Q 145 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 145 34x54 G.S1 H 41 G.S1.02
Ionic TM6 E 259 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 259 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM6 E 259 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 259 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 222 5x63 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 222 5x63 G.H5 L 388 G.H5.20
Polar H8 R 319 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 R 319 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 319 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 142 34x51 G.S3 V 217 G.S3.01
Polar TM5 S 229 5x70 G.H5 R 385 G.H5.17
Hydrophobic TM5 S 229 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 S 229 5x70 G.H5 R 385 G.H5.17
Hydrophobic ICL2 Y 142 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 142 34x51 G.H5 I 383 G.H5.15
Polar ICL2 R 146 34x55 G.HN Q 35 G.HN.52
Hydrophobic TM6 H 262 6x33 G.H5 E 392 G.H5.24
Polar ICL2 R 146 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM6 E 258 6x29 G.H5 E 392 G.H5.24
Van-der-waals TM6 E 258 6x29 G.H5 E 392 G.H5.24
Ionic ICL1 R 60 - G.h2s4 D 240 G.h2s4.03
Polar ICL1 R 60 - G.h2s4 D 240 G.h2s4.03
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 142 34x51 G.S1 H 41 G.S1.02
Polar ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Aromatic ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 142 34x51 G.S3 F 219 G.S3.03
Hydrophobic H8 P 320 8x48 G.H5 E 392 G.H5.24
Ionic H8 R 324 8x52 G.H5 E 392 G.H5.24
Polar H8 R 324 8x52 G.H5 E 392 G.H5.24
Hydrophobic H8 R 319 8x47 G.H5 L 393 G.H5.25
Van-der-waals H8 R 319 8x47 G.H5 L 393 G.H5.25
Polar C-term T 342 - G.h4s6 G 353 G.h4s6.09
Hydrophobic C-term T 342 - G.h4s6 G 353 G.h4s6.09
Van-der-waals C-term T 342 - G.h4s6 G 353 G.h4s6.09
Polar TM5 M 225 5x66 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 225 5x66 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 225 5x66 G.H5 R 385 G.H5.17
Polar TM3 G 139 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 G 139 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 141 34x50 G.H5 I 383 G.H5.15
Polar ICL2 Q 145 34x54 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Q 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 225 5x66 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 141 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 142 34x51 G.H5 C 379 G.H5.11
Polar TM3 S 137 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 H 387 G.H5.19
Polar TM2 S 65 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 S 65 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 65 2x37 G.H5 Q 390 G.H5.22
Polar TM1 R 49 1x60 G.H5 L 393 G.H5.25
Hydrophobic TM1 R 49 1x60 G.H5 L 393 G.H5.25
Van-der-waals TM1 R 49 1x60 G.H5 L 393 G.H5.25
Aromatic TM3 H 140 3x56 G.H5 R 380 G.H5.12
Hydrophobic ICL2 R 146 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 P 236 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 P 236 - G.H4 D 343 G.H4.13
Hydrophobic H8 P 321 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 P 321 8x49 G.H5 L 393 G.H5.25
Polar TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 P 236 - G.hgh4 Y 318 G.hgh4.08
Ionic TM5 R 228 5x69 G.H5 D 381 G.H5.13
Hydrophobic C-term T 342 - G.h4s6 S 352 G.h4s6.08
Van-der-waals C-term T 342 - G.h4s6 S 352 G.h4s6.08
Polar TM5 S 232 5x73 G.S6 C 359 G.S6.01
Aromatic TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Polar TM6 H 262 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 262 6x33 G.H5 L 388 G.H5.20
Hydrophobic H8 P 321 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 P 321 8x49 G.H5 E 392 G.H5.24
Polar TM3 I 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 Q 384 G.H5.16
Polar TM5 R 233 5x74 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 233 5x74 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 233 5x74 G.h4s6 Y 358 G.h4s6.20
Aromatic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 141 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 G 235 5x76 G.H4 L 346 G.H4.16
Hydrophobic H8 P 320 8x48 G.H5 Y 391 G.H5.23
Van-der-waals H8 P 320 8x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 C 234 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 P 141 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 225 5x66 G.H5 Q 384 G.H5.16
Polar TM1 R 49 1x60 G.H5 L 394 G.H5.26
Hydrophobic TM1 R 49 1x60 G.H5 L 394 G.H5.26
Van-der-waals TM1 R 49 1x60 G.H5 L 394 G.H5.26