GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
mevidalen - PAM pubchem gtoplig chembl_ligand ,
CHEMBL1160787 - Agonist chembl_ligand pubchem
PHYSIOLOGICAL LIGANDS
L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline, 5-hydroxytryptamine, dopamine
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | S | 126 | 3x55 | G.H5 | Q | 236 | G.H5.16 |
Van-der-waals | TM3 | S | 126 | 3x55 | G.H5 | Q | 236 | G.H5.16 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | Q | 236 | G.H5.16 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 245 | G.H5.25 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | L | 245 | G.H5.25 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.H4 | R | 199 | G.H4.17 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | E | 244 | G.H5.24 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | E | 244 | G.H5.24 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H2 | I | 235 | G.H2.08 |
Aromatic | ICL2 | F | 129 | 34x51 | G.H5 | F | 228 | G.H5.08 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | F | 228 | G.H5.08 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | F | 228 | G.H5.08 |
Ionic | H8 | R | 338 | 8x51 | G.H5 | E | 244 | G.H5.24 |
Polar | H8 | R | 338 | 8x51 | G.H5 | E | 244 | G.H5.24 |
Polar | TM6 | V | 270 | 6x33 | G.H5 | L | 245 | G.H5.25 |
Hydrophobic | TM6 | V | 270 | 6x33 | G.H5 | L | 245 | G.H5.25 |
Van-der-waals | TM6 | V | 270 | 6x33 | G.H5 | L | 245 | G.H5.25 |
Aromatic | ICL2 | F | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | R | 232 | G.H5.12 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | R | 232 | G.H5.12 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | ICL2 | E | 132 | 34x54 | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | TM7 | F | 333 | 7x55 | G.H5 | E | 244 | G.H5.24 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | L | 246 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 246 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | L | 246 | G.H5.26 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | Q | 236 | G.H5.16 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | R | 237 | G.H5.17 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | R | 237 | G.H5.17 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | R | 237 | G.H5.17 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | H | 239 | G.H5.19 |
Hydrophobic | TM5 | A | 234 | 5x78 | H.HF | L | 198 | H.HF.05 |
Polar | TM5 | A | 238 | 5x82 | G.H4 | R | 199 | G.H4.17 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | R | 199 | G.H4.17 |
Van-der-waals | TM5 | R | 227 | 5x71 | G.H5 | R | 237 | G.H5.17 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 245 | G.H5.25 |
Hydrophobic | TM5 | A | 235 | 5x79 | H.HF | L | 198 | H.HF.05 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | D | 233 | G.H5.13 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | D | 233 | G.H5.13 |
Hydrophobic | TM5 | L | 231 | 5x75 | G.S6 | P | 213 | G.S6.03 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 240 | G.H5.20 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | L | 240 | G.H5.20 |
Polar | TM2 | T | 59 | 2x39 | G.H5 | Y | 243 | G.H5.23 |
Hydrophobic | TM2 | T | 59 | 2x39 | G.H5 | Y | 243 | G.H5.23 |
Van-der-waals | TM2 | T | 59 | 2x39 | G.H5 | Y | 243 | G.H5.23 |
Van-der-waals | TM5 | L | 231 | 5x75 | G.S6 | C | 211 | G.S6.01 |
Ionic | TM5 | R | 227 | 5x71 | G.H5 | D | 233 | G.H5.13 |
Polar | TM5 | R | 227 | 5x71 | G.H5 | D | 233 | G.H5.13 |
Van-der-waals | TM5 | R | 227 | 5x71 | G.H5 | D | 233 | G.H5.13 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 240 | G.H5.20 |
Aromatic | ICL2 | Y | 131 | 34x53 | G.H5 | H | 239 | G.H5.19 |
Hydrophobic | ICL2 | Y | 131 | 34x53 | G.H5 | H | 239 | G.H5.19 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.S3 | V | 79 | G.S3.01 |
Hydrophobic | TM5 | A | 221 | 5x65 | G.H5 | L | 240 | G.H5.20 |
Polar | TM3 | I | 125 | 3x54 | G.H5 | Q | 236 | G.H5.16 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | Q | 236 | G.H5.16 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | Q | 236 | G.H5.16 |
Polar | TM5 | H | 237 | 5x81 | G.hgh4 | T | 171 | G.hgh4.09 |
Hydrophobic | TM5 | H | 237 | 5x81 | G.hgh4 | T | 171 | G.hgh4.09 |
Van-der-waals | TM5 | H | 237 | 5x81 | G.hgh4 | T | 171 | G.hgh4.09 |
Van-der-waals | TM5 | A | 230 | 5x74 | G.hgh4 | D | 175 | G.hgh4.13 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 245 | G.H5.25 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | E | 244 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | E | 244 | G.H5.24 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.h4s6 | T | 202 | G.h4s6.03 |
Hydrophobic | TM5 | H | 237 | 5x81 | G.hgh4 | P | 173 | G.hgh4.11 |
Hydrophobic | TM5 | A | 234 | 5x78 | G.H4 | D | 195 | G.H4.13 |
Van-der-waals | TM5 | A | 234 | 5x78 | G.H4 | D | 195 | G.H4.13 |
Hydrophobic | TM5 | I | 217 | 5x61 | G.H5 | L | 245 | G.H5.25 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.h4s6 | Y | 210 | G.h4s6.20 |
Van-der-waals | TM5 | I | 228 | 5x72 | G.h4s6 | Y | 210 | G.h4s6.20 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | R | 237 | G.H5.17 |
Van-der-waals | TM5 | I | 228 | 5x72 | G.H5 | R | 237 | G.H5.17 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | L | 246 | G.H5.26 |
Hydrophobic | TM5 | E | 232 | 5x76 | G.h4s6 | T | 202 | G.h4s6.03 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | F | 81 | G.S3.03 |
Hydrophobic | TM5 | I | 220 | 5x64 | G.H5 | Q | 236 | G.H5.16 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 245 | G.H5.25 |
Van-der-waals | TM6 | L | 274 | 6x37 | G.H5 | L | 245 | G.H5.25 |
Ionic | ICL2 | E | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | E | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | E | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Aromatic | TM3 | R | 121 | 3x50 | G.H5 | Y | 243 | G.H5.23 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | Y | 243 | G.H5.23 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | Y | 243 | G.H5.23 |
Polar | TM3 | S | 126 | 3x55 | G.H5 | R | 232 | G.H5.12 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | Y | 243 | G.H5.23 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | D | 195 | G.H4.13 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | D | 195 | G.H4.13 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | V | 79 | G.S3.01 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S3 | V | 79 | G.S3.01 |
Polar | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 78 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 78 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 78 | G.s2s3.02 |
Van-der-waals | TM2 | K | 57 | 2x37 | G.H5 | Q | 242 | G.H5.22 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | C | 231 | G.H5.11 |
Polar | TM6 | R | 266 | 6x29 | G.h4s6 | Y | 210 | G.h4s6.20 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.h4s6 | Y | 210 | G.h4s6.20 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.h4s6 | Y | 210 | G.h4s6.20 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.H4 | R | 199 | G.H4.17 |
Van-der-waals | TM5 | K | 239 | 5x83 | G.H4 | R | 199 | G.H4.17 |
Van-der-waals | H8 | N | 334 | 8x47 | G.H5 | Q | 242 | G.H5.22 |
Hydrophobic | TM5 | L | 231 | 5x75 | H.HF | L | 198 | H.HF.05 |
Van-der-waals | TM5 | L | 231 | 5x75 | H.HF | L | 198 | H.HF.05 |
Hydrophobic | TM5 | I | 225 | 5x69 | G.H5 | L | 246 | G.H5.26 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | R | 232 | G.H5.12 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | R | 232 | G.H5.12 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | Y | 243 | G.H5.23 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.h4s6 | A | 203 | G.h4s6.04 |