PAR2 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

May 7, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

No ligands

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 S 184 - G.H5 E 362 G.H5.26
Van-der-waals ICL2 S 184 - G.H5 E 362 G.H5.26
Hydrophobic ICL4 S 348 - G.H5 N 364 G.H5.26
Van-der-waals ICL4 S 348 - G.H5 N 364 G.H5.26
Hydrophobic TM3 Q 172 3x49 G.H5 Y 363 G.H5.26
Polar ICL2 G 182 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 G 182 - G.hns1 R 37 G.hns1.02
Polar TM3 R 173 3x50 G.H5 Y 363 G.H5.26
Hydrophobic TM3 R 173 3x50 G.H5 Y 363 G.H5.26
Van-der-waals TM3 R 173 3x50 G.H5 Y 363 G.H5.26
Hydrophobic TM6 I 289 6x38 G.H5 L 365 G.H5.26
Hydrophobic TM3 I 177 3x54 G.H5 N 359 G.H5.26
Hydrophobic TM3 I 177 3x54 G.H5 L 356 G.H5.23
Polar TM3 R 173 3x50 G.H5 N 364 G.H5.26
Van-der-waals TM3 R 173 3x50 G.H5 N 364 G.H5.26
Polar TM6 K 281 6x30 G.S6 G 327 G.S6.04
Hydrophobic TM6 K 281 6x30 G.S6 G 327 G.S6.04
Hydrophobic TM6 K 281 6x30 G.s6h5 I 330 G.s6h5.02
Polar TM6 R 284 6x33 G.H5 V 366 G.H5.26
Hydrophobic TM6 R 284 6x33 G.H5 V 366 G.H5.26
Van-der-waals TM6 R 284 6x33 G.H5 V 366 G.H5.26
Hydrophobic TM6 A 285 6x34 G.H5 L 360 G.H5.26
Hydrophobic TM3 I 177 3x54 G.H5 L 365 G.H5.26
Van-der-waals TM3 I 177 3x54 G.H5 L 365 G.H5.26
Hydrophobic ICL3 M 274 - G.H5 L 356 G.H5.23
Polar TM3 V 176 3x53 G.H5 N 359 G.H5.26
Hydrophobic TM3 V 176 3x53 G.H5 N 359 G.H5.26
Van-der-waals TM3 V 176 3x53 G.H5 N 359 G.H5.26
Hydrophobic TM6 L 288 6x37 G.H5 L 365 G.H5.26
Hydrophobic TM3 V 176 3x53 G.H5 Y 363 G.H5.26
Van-der-waals TM3 V 176 3x53 G.H5 Y 363 G.H5.26
Hydrophobic TM3 R 173 3x50 G.H5 L 365 G.H5.26
Van-der-waals TM3 R 173 3x50 G.H5 L 365 G.H5.26
Aromatic TM2 H 108 2x37 G.H5 Y 363 G.H5.26
Hydrophobic TM2 H 108 2x37 G.H5 Y 363 G.H5.26
Van-der-waals TM2 H 108 2x37 G.H5 Y 363 G.H5.26
Hydrophobic ICL2 P 180 - G.H5 I 355 G.H5.22
Hydrophobic TM5 M 268 5x64 G.H5 L 356 G.H5.23
Hydrophobic ICL2 R 185 - G.hns1 R 37 G.hns1.02
Polar ICL3 N 277 - G.H5 Q 357 G.H5.24
Hydrophobic ICL3 N 277 - G.s6h5 I 330 G.s6h5.02
Van-der-waals ICL3 N 277 - G.s6h5 I 330 G.s6h5.02
Hydrophobic TM6 L 288 6x37 G.H5 V 366 G.H5.26
Hydrophobic TM5 L 269 5x65 G.H5 L 360 G.H5.26
Hydrophobic TM2 M 114 2x43 G.H5 N 364 G.H5.26
Van-der-waals TM2 M 114 2x43 G.H5 N 364 G.H5.26
Hydrophobic TM2 A 110 2x39 G.H5 Y 363 G.H5.26
Ionic TM2 H 108 2x37 G.H5 E 362 G.H5.26
Polar TM2 H 108 2x37 G.H5 E 362 G.H5.26
Hydrophobic TM2 H 108 2x37 G.H5 E 362 G.H5.26
Van-der-waals TM2 H 108 2x37 G.H5 E 362 G.H5.26
Hydrophobic TM6 K 281 6x30 G.H5 Q 357 G.H5.24
Van-der-waals TM6 K 281 6x30 G.H5 Q 357 G.H5.24
Polar ICL3 N 277 - G.s6h5 C 331 G.s6h5.03
Hydrophobic TM5 M 265 5x61 G.H5 L 365 G.H5.26
Hydrophobic TM3 I 177 3x54 G.H5 L 360 G.H5.26
Van-der-waals TM3 I 177 3x54 G.H5 L 360 G.H5.26
Polar ICL3 D 275 - G.H5 D 353 G.H5.20
Hydrophobic ICL3 D 275 - G.H5 D 353 G.H5.20
Van-der-waals ICL3 D 275 - G.H5 D 353 G.H5.20
Hydrophobic ICL3 D 275 - G.s6h5 Y 332 G.s6h5.04
Polar TM6 A 285 6x34 G.H5 L 365 G.H5.26
Hydrophobic TM6 A 285 6x34 G.H5 L 365 G.H5.26
Van-der-waals TM6 A 285 6x34 G.H5 L 365 G.H5.26
Hydrophobic TM6 K 281 6x30 G.H5 V 366 G.H5.26