Refined structure (6PB1) of Gs - CRF2 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (57.6%), 167 from model (42.4%)
Residue sidechains - 225 from structure (57.1%), 169 from model (42.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 276 from structure (69.3%), 122 from model (30.7%)
Residue sidechains - 276 from structure (69.3%), 122 from model (30.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 H - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 A - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 C - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 E - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 L - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 D - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 W - AF2 AF2
N-term 28 G - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 P - AF2 AF2
N-term 31 L - AF2 AF2
N-term 32 D - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 E - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 Y - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 Y - AF2 AF2
N-term 40 C - AF2 AF2
N-term 41 N - AF2 AF2
N-term 42 T - AF2 AF2
N-term 43 T - AF2 AF2
N-term 44 L - AF2 AF2
N-term 45 D - AF2 AF2
N-term 46 Q - AF2 AF2
N-term 47 I - AF2 AF2
N-term 48 G - AF2 AF2
N-term 49 T - AF2 AF2
N-term 50 C - AF2 AF2
N-term 51 W - AF2 AF2
N-term 52 P - AF2 AF2
N-term 53 R - AF2 AF2
N-term 54 S - AF2 AF2
N-term 55 A - AF2 AF2
N-term 56 A - AF2 AF2
N-term 57 G - AF2 AF2
N-term 58 A - AF2 AF2
N-term 59 L - AF2 AF2
N-term 60 V - AF2 AF2
N-term 61 E - AF2 AF2
N-term 62 R - AF2 AF2
N-term 63 P - AF2 AF2
N-term 64 C - AF2 AF2
N-term 65 P - AF2 AF2
N-term 66 E - AF2 AF2
N-term 67 Y - AF2 AF2
N-term 68 F - AF2 AF2
N-term 69 N - AF2 AF2
N-term 70 G - AF2 AF2
N-term 71 V - AF2 AF2
N-term 72 K - AF2 AF2
N-term 73 Y - AF2 AF2
N-term 74 N - AF2 AF2
N-term 75 T - AF2 AF2
N-term 76 T - AF2 AF2
N-term 77 R - AF2 AF2
N-term 78 N - AF2 AF2
N-term 79 A - AF2 AF2
N-term 80 Y - AF2 AF2
N-term 81 R - AF2 AF2
N-term 82 E - AF2 AF2
N-term 83 C - AF2 AF2
N-term 84 L - AF2 AF2
N-term 85 E - AF2 AF2
N-term 86 N - AF2 AF2
N-term 87 G - AF2 AF2
N-term 88 T - AF2 AF2
N-term 89 W - AF2 AF2
N-term 90 A - AF2 AF2
N-term 91 S - AF2 AF2
N-term 92 K - AF2 AF2
N-term 93 I - AF2 AF2
N-term 94 N - AF2 AF2
N-term 95 Y - AF2 AF2
N-term 96 S - AF2 AF2
N-term 97 Q - AF2 AF2
N-term 98 C - AF2 AF2
N-term 99 E - AF2 AF2
TM1 100 P 1.23x23 AF2 AF2
TM1 101 I 1.24x24 AF2 AF2
TM1 102 L 1.25x25 AF2 AF2
TM1 103 D 1.26x26 AF2 AF2
TM1 104 D 1.27x27 AF2 AF2
TM1 105 K 1.28x28 AF2 AF2
TM1 106 Q 1.29x29 AF2 AF2
TM1 107 R 1.30x30 AF2 AF2
TM1 108 K 1.31x31 AF2 AF2
TM1 109 Y 1.32x32 AF2 AF2
TM1 110 D 1.33x33 AF2 AF2
TM1 111 L 1.34x34 Structure Structure
TM1 112 H 1.35x35 Structure Structure
TM1 113 Y 1.36x36 Structure Structure
TM1 114 R 1.37x37 Structure Structure
TM1 115 I 1.38x38 Structure Structure
TM1 116 A 1.39x39 Structure Structure
TM1 117 L 1.40x40 Structure Structure
TM1 118 V 1.41x41 Structure Structure
TM1 119 V 1.42x42 Structure Structure
TM1 120 N 1.43x43 Structure Structure
TM1 121 Y 1.44x44 Structure Structure
TM1 122 L 1.45x45 Structure Structure
TM1 123 G 1.46x46 Structure Structure
TM1 124 H 1.47x47 Structure Structure
TM1 125 C 1.48x48 Structure Structure
TM1 126 V 1.49x49 Structure Structure
TM1 127 S 1.50x50 Structure Structure
TM1 128 V 1.51x51 Structure Structure
TM1 129 A 1.52x52 Structure Structure
TM1 130 A 1.53x53 Structure Structure
TM1 131 L 1.54x54 Structure Structure
TM1 132 V 1.55x55 Structure Structure
TM1 133 A 1.56x56 Structure Structure
TM1 134 A 1.57x57 Structure Structure
TM1 135 F 1.58x58 Structure Structure
TM1 136 L 1.59x59 Structure Structure
TM1 137 L 1.60x60 Structure Structure
TM1 138 F 1.61x61 Structure Structure
TM1 139 L 1.62x62 Structure Structure
TM1 140 A 1.63x63 Structure Structure
TM1 141 L 1.64x64 Structure Structure
ICL1 142 R 12.48x48 Structure Structure
ICL1 143 S 12.49x49 Structure Structure
ICL1 144 I 12.50x50 Structure Structure
ICL1 145 R 12.51x51 Structure Structure
TM2 146 C 2.44x44 Structure Structure
TM2 147 L 2.45x45 Structure Structure
TM2 148 R 2.46x46 Structure Structure
TM2 149 N 2.47x47 Structure Structure
TM2 150 V 2.48x48 Structure Structure
TM2 151 I 2.49x49 Structure Structure
TM2 152 H 2.50x50 Structure Structure
TM2 153 W 2.51x51 Structure Structure
TM2 154 N 2.52x52 Structure Structure
TM2 155 L 2.53x53 Structure Structure
TM2 156 I 2.54x54 Structure Structure
TM2 157 T 2.55x55 Structure Structure
TM2 158 T 2.56x56 Structure Structure
TM2 159 F 2.57x57 Structure Structure
TM2 160 I 2.58x58 Structure Structure
TM2 161 L 2.59x59 Structure Structure
TM2 162 R 2.60x60 Structure Structure
TM2 163 N 2.61x61 Structure Structure
TM2 164 V 2.62x62 Structure Structure
TM2 165 M 2.63x63 Structure Structure
TM2 166 W 2.64x64 Structure Structure
TM2 167 F 2.65x65 Structure Structure
TM2 168 L 2.66x66 Structure Structure
TM2 169 L 2.67x67 Structure Structure
TM2 170 Q 2.68x68 Structure Structure
TM2 171 L 2.69x69 Structure Structure
TM2 172 V 2.70x70 Structure Structure
ECL1 173 D - Structure Structure
ECL1 174 H - Structure Structure
ECL1 175 E - Structure Structure
ECL1 176 V - Structure Structure
ECL1 177 H - Structure Structure
ECL1 178 E - Structure Structure
ECL1 179 S - Structure Structure
ECL1 180 N - Structure Structure
TM3 181 E 3.26x26 Structure Structure
TM3 182 V 3.27x27 Structure Structure
TM3 183 W 3.28x28 Structure Structure
TM3 184 C 3.29x29 Structure Structure
TM3 185 R 3.30x30 Structure Structure
TM3 186 C 3.31x31 Structure Structure
TM3 187 I 3.32x32 Structure Structure
TM3 188 T 3.33x33 Structure Structure
TM3 189 T 3.34x34 Structure Structure
TM3 190 I 3.35x35 Structure Structure
TM3 191 F 3.36x36 Structure Structure
TM3 192 N 3.37x37 Structure Structure
TM3 193 Y 3.38x38 Structure Structure
TM3 194 F 3.39x39 Structure Structure
TM3 195 V 3.40x40 Structure Structure
TM3 196 V 3.41x41 Structure Structure
TM3 197 T 3.42x42 Structure Structure
TM3 198 N 3.43x43 Structure Structure
TM3 199 F 3.44x44 Structure Structure
TM3 200 F 3.45x45 Structure Structure
TM3 201 W 3.46x46 Structure Structure
TM3 202 M 3.47x47 Structure Structure
TM3 203 F 3.48x48 Structure Structure
TM3 204 V 3.49x49 Structure Structure
TM3 205 E 3.50x50 Structure Structure
TM3 206 G 3.51x51 Structure Structure
TM3 207 C 3.52x52 Structure Structure
TM3 208 Y 3.53x53 Structure Structure
TM3 209 L 3.54x54 Structure Structure
TM3 210 H 3.55x55 Structure Structure
TM3 211 T 3.56x56 Structure Structure
TM3 212 A 3.57x57 Structure Structure
TM3 213 I 3.58x58 Structure Structure
TM3 214 V 3.59x59 Structure Structure
TM3 215 M 3.60x60 Structure Structure
ICL2 216 T - Structure Structure
ICL2 217 Y - Structure Structure
ICL2 218 S - Structure Structure
ICL2 219 T - Structure Structure
ICL2 220 E - Structure Structure
ICL2 221 R - Structure Structure
ICL2 222 L - Structure Structure
TM4 223 R 4.41x42 Structure Structure
TM4 224 K 4.42x43 Structure Structure
TM4 225 C 4.43x44 Structure Structure
TM4 226 L 4.44x45 Structure Structure
TM4 227 F 4.45x46 Structure Structure
TM4 228 L 4.46x47 Structure Structure
TM4 229 F 4.47x48 Structure Structure
TM4 230 I 4.48x49 Structure Structure
TM4 231 G 4.49x491 Structure Structure
TM4 232 W 4.50x50 Structure Structure
TM4 233 C 4.51x51 Structure Structure
TM4 234 I 4.52x52 Structure Structure
TM4 235 P 4.53x53 Structure Structure
TM4 236 F 4.54x54 Structure Structure
TM4 237 P 4.55x55 Structure Structure
TM4 238 I 4.56x56 Structure Structure
TM4 239 I 4.57x57 Structure Structure
TM4 240 V 4.58x58 Structure Structure
TM4 241 A 4.59x59 Structure Structure
TM4 242 W 4.60x60 Structure Structure
TM4 243 A 4.61x61 Structure Structure
TM4 244 I 4.62x62 Structure Structure
TM4 245 G 4.63x63 Structure Structure
TM4 246 K 4.64x64 Structure Structure
TM4 247 L 4.65x65 Structure Structure
TM4 248 Y 4.66x66 Structure Structure
TM4 249 Y 4.67x67 Structure Structure
TM4 250 E 4.68x68 Structure Structure
ECL2 251 N - Structure Structure
ECL2 252 E - Structure Structure
ECL2 253 Q - Structure Structure
ECL2 254 C 45.50x50 Structure Structure
ECL2 255 W 45.51x51 Structure Structure
ECL2 256 F 45.52x52 Structure Structure
ECL2 257 G - Structure Structure
ECL2 258 K - Structure Structure
ECL2 259 E - Structure Structure
ECL2 260 P - Structure Structure
ECL2 261 G - Structure Structure
ECL2 262 D - Structure Structure
ECL2 263 L - Structure Structure
TM5 264 V 5.35x36 Structure Structure
TM5 265 D 5.36x37 Structure Structure
TM5 266 Y 5.37x38 Structure Structure
TM5 267 I 5.38x381 Structure Structure
TM5 268 Y 5.39x39 Structure Structure
TM5 269 Q 5.40x40 Structure Structure
TM5 270 G 5.41x41 Structure Structure
TM5 271 P 5.42x42 Structure Structure
TM5 272 I 5.43x43 Structure Structure
TM5 273 I 5.44x44 Structure Structure
TM5 274 L 5.45x45 Structure Structure
TM5 275 V 5.46x46 Structure Structure
TM5 276 L 5.47x47 Structure Structure
TM5 277 L 5.48x48 Structure Structure
TM5 278 I 5.49x49 Structure Structure
TM5 279 N 5.50x50 Structure Structure
TM5 280 F 5.51x51 Structure Structure
TM5 281 V 5.52x52 Structure Structure
TM5 282 F 5.53x53 Structure Structure
TM5 283 L 5.54x54 Structure Structure
TM5 284 F 5.55x55 Structure Structure
TM5 285 N 5.56x56 Structure Structure
TM5 286 I 5.57x57 Structure Structure
TM5 287 V 5.58x58 Structure Structure
TM5 288 R 5.59x59 Structure Structure
TM5 289 I 5.60x60 Structure Structure
TM5 290 L 5.61x61 Structure Structure
TM5 291 M 5.62x62 Structure Structure
TM5 292 T 5.63x63 Structure Structure
TM5 293 K 5.64x64 Structure Structure
TM5 294 L 5.65x65 Structure Structure
TM5 295 R 5.66x66 Structure Structure
TM5 296 A 5.67x67 Structure Structure
ICL3 297 S - Structure Structure
ICL3 298 T - Structure Structure
ICL3 299 T - Structure Structure
TM6 300 S 6.30x30 Structure Structure
TM6 301 E 6.31x31 Structure Structure
TM6 302 T 6.32x32 Structure Structure
TM6 303 I 6.33x33 Structure Structure
TM6 304 Q 6.34x34 Structure Structure
TM6 305 Y 6.35x35 Structure Structure
TM6 306 R 6.36x36 Structure Structure
TM6 307 K 6.37x37 Structure Structure
TM6 308 A 6.38x38 Structure Structure
TM6 309 V 6.39x39 Structure Structure
TM6 310 K 6.40x40 Structure Structure
TM6 311 A 6.41x41 Structure Structure
TM6 312 T 6.42x42 Structure Structure
TM6 313 L 6.43x43 Structure Structure
TM6 314 V 6.44x44 Structure Structure
TM6 315 L 6.45x45 Structure Structure
TM6 316 L 6.46x46 Structure Structure
TM6 317 P 6.47x47 Structure Structure
TM6 318 L 6.48x48 Structure Structure
TM6 319 L 6.49x49 Structure Structure
TM6 320 G 6.50x50 Structure Structure
TM6 321 I 6.51x51 Structure Structure
TM6 322 T 6.52x52 Structure Structure
TM6 323 Y 6.53x53 Structure Structure
TM6 324 M 6.54x54 Structure Structure
TM6 325 L 6.55x55 Structure Structure
TM6 326 F 6.56x56 Structure Structure
TM6 327 F 6.57x57 Structure Structure
TM6 328 V 6.58x58 Structure Structure
ECL3 329 N - Structure Structure
ECL3 330 P - Structure Structure
ECL3 331 G - Structure Structure
ECL3 332 E - Structure Structure
ECL3 333 D - Structure Structure
TM7 334 D 7.32x31 Structure Structure
TM7 335 L 7.33x32 Structure Structure
TM7 336 S 7.34x33 Structure Structure
TM7 337 Q 7.35x34 Structure Structure
TM7 338 I 7.36x35 Structure Structure
TM7 339 M 7.37x36 Structure Structure
TM7 340 F 7.38x37 Structure Structure
TM7 341 I 7.39x38 Structure Structure
TM7 342 Y 7.40x39 Structure Structure
TM7 343 F 7.41x40 Structure Structure
TM7 344 N 7.42x41 Structure Structure
TM7 345 S 7.43x42 Structure Structure
TM7 346 F 7.44x43 Structure Structure
TM7 347 L 7.45x44 Structure Structure
TM7 348 Q 7.46x45 Structure Structure
TM7 349 S 7.47x46 Structure Structure
TM7 350 F 7.48x47 Structure Structure
TM7 351 Q 7.49x49 Structure Structure
TM7 352 G 7.50x50 Structure Structure
TM7 353 F 7.51x51 Structure Structure
TM7 354 F 7.52x52 Structure Structure
TM7 355 V 7.53x53 Structure Structure
TM7 356 S 7.54x54 Structure Structure
TM7 357 V 7.55x55 Structure Structure
TM7 358 F 7.56x56 Structure Structure
TM7 359 Y 7.57x57 Structure Structure
TM7 360 C 7.58x58 Structure Structure
TM7 361 F 7.59x59 Structure Structure
TM7 362 F 7.60x60 Structure Structure
H8 363 N 8.47x47 Structure Structure
H8 364 G 8.48x48 Structure Structure
H8 365 E 8.49x49 Structure Structure
H8 366 V 8.50x50 Structure Structure
H8 367 R 8.51x51 Structure Structure
H8 368 S 8.52x52 Structure Structure
H8 369 A 8.53x53 Structure Structure
H8 370 V 8.54x54 Structure Structure
H8 371 R 8.55x55 Structure Structure
H8 372 K 8.56x56 Structure Structure
H8 373 R 8.57x57 Structure Structure
H8 374 W 8.58x58 Structure Structure
H8 375 H 8.59x59 Structure Structure
H8 376 R 8.60x60 Structure Structure
H8 377 W 8.61x61 Structure Structure
H8 378 Q 8.62x62 Structure Structure
H8 379 D 8.63x63 Structure Structure
H8 380 H 8.64x64 Structure Structure
H8 381 H 8.65x65 Structure Structure
H8 382 S 8.66x66 Structure Structure
H8 383 L 8.67x67 Structure Structure
H8 384 R 8.68x68 Structure Structure
H8 385 V 8.69x69 Structure Structure
H8 386 P 8.70x70 Structure Structure
H8 387 M 8.71x71 AF2 AF2
H8 388 A 8.72x72 AF2 AF2
C-term 389 R - AF2 AF2
C-term 390 A - AF2 AF2
C-term 391 M - AF2 AF2
C-term 392 S - AF2 AF2
C-term 393 I - AF2 AF2
C-term 394 P - AF2 AF2
C-term 395 T - AF2 AF2
C-term 396 S - AF2 AF2
C-term 397 P - AF2 AF2
C-term 398 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 216 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 290 5x61 G.H5 L 394 G.H5.26
Ionic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 Y 217 - G.S3 F 219 G.S3.03
Hydrophobic TM3 I 213 3x58 G.H5 L 388 G.H5.20
Polar ICL2 Y 217 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 217 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 217 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 217 - G.H5 F 376 G.H5.08
Polar TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Polar TM3 V 214 3x59 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 214 3x59 G.H5 Q 384 G.H5.16
Hydrophobic TM6 K 307 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 307 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 294 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 293 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 220 - G.hns1 A 39 G.hns1.03
Hydrophobic TM7 F 358 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 T 219 - G.H5 H 387 G.H5.19
Polar ICL3 S 297 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 297 - G.H5 R 385 G.H5.17
Polar TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 216 - G.H5 R 380 G.H5.12
Hydrophobic TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 217 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 217 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 290 5x61 G.H5 L 388 G.H5.20
Hydrophobic H8 N 363 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 290 5x61 G.H5 L 393 G.H5.25
Polar ICL2 Y 217 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 217 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 216 - G.H5 I 383 G.H5.15
Polar TM5 K 293 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 293 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL2 E 220 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 220 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 K 293 5x64 G.H5 L 388 G.H5.20
Polar ICL3 S 297 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 S 297 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 A 311 6x41 G.H5 L 393 G.H5.25
Aromatic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Polar TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 217 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 315 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 212 3x57 G.H5 H 387 G.H5.19