HCA3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Oct. 29, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

D-phenyllactic acid - Agonist pubchem gtoplig drugbank pubchem

PHYSIOLOGICAL LIGANDS

3-hydroxyoctanoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16
Hydrophobic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 P 299 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 P 299 8x48 G.H5 L 353 G.H5.25
Ionic TM3 R 128 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 128 3x53 G.H5 D 350 G.H5.22
Ionic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 133 - G.S3 L 194 G.S3.01
Van-der-waals ICL3 M 220 - G.H5 K 345 G.H5.17
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Hydrophobic TM6 A 229 6x33 G.H5 F 354 G.H5.26
Polar TM2 R 63 2x40 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Ionic ICL3 R 222 - G.H5 D 341 G.H5.13
Hydrophobic H8 P 299 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 299 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 226 6x30 G.H5 L 348 G.H5.20
Hydrophobic H8 P 299 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 P 299 8x48 G.H5 G 352 G.H5.24
Polar TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 124 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 F 232 6x36 G.H5 L 353 G.H5.25
Polar TM5 R 218 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic H8 S 298 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 H 223 - G.H5 K 345 G.H5.17
Ionic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 138 - G.hns1 R 32 G.hns1.03
Ionic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 133 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 - G.H5 T 340 G.H5.12
Polar ICL2 P 132 - G.H5 N 347 G.H5.19