Refined structure (7VVN) of Gs - PTH1 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 230 from structure (58.4%), 164 from model (41.6%)
Residue sidechains - 208 from structure (52.8%), 186 from model (47.2%)

REFINED GPCR RESIDUES

Residue backbones - 300 from structure (60.2%), 198 from model (39.8%)
Residue sidechains - 238 from structure (47.8%), 260 from model (52.2%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
H02G.S1R12D13Q16Q22G.H5GproteinM3x60F-R2x46K5x64H12x51GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S1G.H5GPCR segments:ICL1TM2ICL2TM3TM5

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null12x512x382x393x503x533x543x564x395x615x655x685x696x366x40G.H5.26G.H5.25G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.h4s6.20G.h4s6.03G.H4.16G.H4.13G.H4.12G.S3.01G.S1.02Res. Pos.PTH1 (7VVN_REFINED)- (7VVN_REFINED)---------------HTRLLIMEILKLSLHTRLLIMEILKLSLRQYLHQLRLDRRDLFCIHVTY

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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