LPA6 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Jan. 15, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

LPA - Agonist pubchem

PHYSIOLOGICAL LIGANDS

LPA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM3 D 113 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 113 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 L 211 - G.H5 L 388 G.H5.20
Hydrophobic TM3 I 118 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM3 I 118 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 121 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 118 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 121 - G.H5 K 380 G.H5.12
Polar TM3 A 117 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 117 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 117 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 117 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 117 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 125 - G.H5 I 383 G.H5.15
Polar ICL2 K 125 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 125 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 126 - G.hns1 R 39 G.hns1.03
Hydrophobic TM6 M 230 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 230 6x36 G.H5 L 393 G.H5.25
Polar ICL2 R 128 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 128 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 128 - G.H5 Y 391 G.H5.23
Polar ICL2 R 128 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 122 - G.S1 L 41 G.S1.02
Hydrophobic TM2 T 52 2x39 G.H5 Y 391 G.H5.23
Van-der-waals ICL3 N 223 - G.H5 V 394 G.H5.26
Aromatic ICL2 F 122 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 122 - G.H5 F 376 G.H5.08
Hydrophobic ICL3 K 226 - G.H5 V 394 G.H5.26
Van-der-waals ICL3 K 226 - G.H5 V 394 G.H5.26
Polar ICL3 K 226 - G.H5 L 393 G.H5.25
Hydrophobic ICL3 K 226 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 K 226 - G.H5 L 393 G.H5.25
Polar ICL3 V 227 - G.H5 L 393 G.H5.25
Hydrophobic ICL3 V 227 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 V 227 - G.H5 L 393 G.H5.25
Hydrophobic TM3 R 114 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 114 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 122 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 122 - G.H5 I 383 G.H5.15
Ionic ICL2 R 128 - G.H5 E 390 G.H5.22
Polar ICL2 R 128 - G.H5 E 390 G.H5.22
Hydrophobic ICL2 F 122 - G.H5 K 380 G.H5.12
Hydrophobic TM3 R 114 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 122 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 F 122 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 118 3x54 G.H5 N 387 G.H5.19