PDB
9ITB
Resolution
2.9 Å
Released
Jan. 15, 2025
Receptor
LPA6
Class
A
Species
Homo sapiens
Ligand
LPA
Function
Agonist
Reference
10.1073/PNAS.2415426122

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Ligand Amino Acid Generic Number Segment Interaction Type
LPA Y97 3.33x33 TM3 hydrophobic
LPA Y101 3.37x37 TM3 hydrophobic
LPA F169 45.51x51 ECL2 polar (hydrogen bond with backbone)
LPA F169 45.51x51 ECL2 Van der Waals
LPA N171 ECL2 Van der Waals
LPA N171 ECL2 polar (hydrogen bond with backbone)
LPA F172 ECL2 Van der Waals
LPA F172 ECL2 polar (hydrogen bond with backbone)
LPA W177 5.31x32 TM5 polar (hydrogen bond)
LPA W177 5.31x32 TM5 Van der Waals
LPA L181 5.35x36 TM5 hydrophobic
LPA I184 5.38x39 TM5 Van der Waals
LPA F187 5.41x42 TM5 hydrophobic
LPA F187 5.41x42 TM5 Van der Waals
LPA I188 5.42x43 TM5 hydrophobic
LPA I188 5.42x43 TM5 Van der Waals
LPA V191 5.45x46 TM5 hydrophobic
LPA V191 5.45x46 TM5 Van der Waals
LPA Y252 6.58x58 TM6 polar (hydrogen bond)
LPA Y252 6.58x58 TM6 Van der Waals
LPA R256 6.62x62 TM6 Van der Waals
LPA Y273 7.35x34 TM7 polar (hydrogen bond)
LPA Y273 7.35x34 TM7 Van der Waals

LPA

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Snake plot — Download: PNG | SVG
ICL1 L K V R ICL1ECL1 N W P F ECL1ICL2 P F K S K T L R ICL2ECL2 Q S T H S Q G N N A S E A C F E N F ECL2ICL3 K P V T L S R S K I ICL3ECL3 T F V ECL3N-term M V S V N S S H C F Y N D S N-termC-term S V R R S D F R F S E V H G A E N F I Q H N L Q T L K S K I F D N E S A A C-term F K Y T L Y G C M F S M V F V L G L I S N C V A I Y I F I C V N E T T T Y M I N L A M S D L L F V F T L P F R I F Y F T T R G D L L C K I S V M L F Y T N M Y G S I L F L T C I S V D R F L A I V Y T K R N A K I V C T G V W L T V I G G S A P A V F V P E A T W K T Y L S R I V I F I E I V G F F I P L I L N V T C S S M V L K T L T N K T K V L K M I F V H L I I F C F C F V P Y N I N L I L Y S L V R T Q N C S V V A A V R T M Y P I T L C I A V S N C C F D P I V Y Y F T S D T I K M I Q N S K N W
Helix box plot — Download: PNG | SVG C N S I L G L V F V M S F M C G Y L T Y 1 I N L A M S D L L F V F T L P F R I F Y 2 C T L F L I S G Y M N T Y F L M V S I K 3 A K I V C T G V W L T V I G G S A P A 4 S C T V N L I L P I F F G V I E I F I V I 5 F V H L I I F C F C F V P Y N I N L I L 6 I P D F C C N S V A I C L T I P Y M T 7

GPCRdb(A)
GPCRdb(A)
LPA6 receptor
TM3
3x33 3.33x33 Y97
3x37 3.37x37 Y101
ECL2
45x51 45.51x51 F169
TM5
5x32 5.31x32 W177
5x36 5.35x36 L181
5x39 5.38x39 I184
5x42 5.41x42 F187
5x43 5.42x43 I188
5x46 5.45x46 V191
TM6
6x58 6.58x58 Y252
6x62 6.62x62 R256
TM7
7x34 7.35x34 Y273