FFA1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

May 24, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

fasiglifam - Agonist pubchem gtoplig chembl_ligand drugbank

ENDOGENOUS LIGANDS

myristic acid, oleic acid, α-linolenic acid, docosahexaenoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 112 34x51 G.H5 K 224 G.H5.12
Polar ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Van-der-waals ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Hydrophobic TM6 R 218 6x30 G.h4s6 G 199 G.h4s6.11
Van-der-waals TM6 R 218 6x30 G.h4s6 G 199 G.h4s6.11
Hydrophobic ICL2 P 111 34x50 G.H5 K 224 G.H5.12
Polar TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Hydrophobic TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Van-der-waals TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Ionic ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Polar ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Hydrophobic ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Van-der-waals ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Polar TM5 S 212 5x68 G.H5 D 225 G.H5.13
Hydrophobic TM5 S 212 5x68 G.H5 D 225 G.H5.13
Van-der-waals TM5 S 212 5x68 G.H5 D 225 G.H5.13
Hydrophobic TM3 R 104 3x50 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 Q 115 34x54 G.H5 I 227 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 227 G.H5.15
Hydrophobic ICL3 L 214 - G.H5 Q 229 G.H5.17
Van-der-waals ICL3 L 214 - G.H5 Q 229 G.H5.17
Polar TM6 A 222 6x34 G.H5 L 237 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 237 G.H5.25
Van-der-waals TM6 A 222 6x34 G.H5 L 237 G.H5.25
Hydrophobic TM2 T 39 2x37 G.s4h3 E 234 G.s4h3.03
Van-der-waals TM2 T 39 2x37 G.s4h3 E 234 G.s4h3.03
Polar TM6 R 218 6x30 G.h4s6 D 198 G.h4s6.10
Hydrophobic TM3 R 104 3x50 G.H5 L 237 G.H5.25
Hydrophobic ICL2 A 116 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 214 - G.s4h3 V 238 G.s4h3.07
Hydrophobic ICL2 L 112 34x51 G.S3 V 71 G.S3.01
Van-der-waals ICL2 L 112 34x51 G.S3 V 71 G.S3.01
Hydrophobic TM6 V 225 6x37 G.H5 L 237 G.H5.25
Van-der-waals TM6 V 225 6x37 G.H5 L 237 G.H5.25
Hydrophobic TM6 A 226 6x38 G.H5 L 237 G.H5.25
Polar TM2 S 41 2x39 G.H5 Y 235 G.H5.23
Hydrophobic TM2 S 41 2x39 G.H5 Y 235 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 Y 235 G.H5.23
Polar TM3 G 107 3x53 G.H5 N 231 G.H5.19
Hydrophobic TM3 G 107 3x53 G.H5 N 231 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 231 G.H5.19
Hydrophobic TM3 L 100 3x46 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 N 231 G.H5.19
Polar ICL2 P 111 34x50 G.H5 N 231 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 N 231 G.H5.19
Hydrophobic ICL3 L 214 - G.h4s6 G 199 G.h4s6.11
Van-der-waals ICL3 L 214 - G.h4s6 G 199 G.h4s6.11
Hydrophobic ICL2 L 112 34x51 G.H5 I 227 G.H5.15
Hydrophobic ICL2 F 117 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 117 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 209 5x65 G.H5 L 232 G.H5.20
Van-der-waals TM5 L 209 5x65 G.H5 L 232 G.H5.20
Hydrophobic ICL2 P 111 34x50 G.H5 I 227 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 227 G.H5.15
Hydrophobic ICL2 P 111 34x50 G.H5 L 228 G.H5.16
Hydrophobic TM3 A 108 3x54 G.H5 L 228 G.H5.16
Van-der-waals TM3 A 108 3x54 G.H5 L 228 G.H5.16
Hydrophobic TM6 R 218 6x30 G.s4h3 V 238 G.s4h3.07
Van-der-waals TM6 R 218 6x30 G.s4h3 V 238 G.s4h3.07