PDB
8EJK
Resolution
3.4 Å
Released
May 24, 2023
Receptor
FFA1
Class
A
Species
Homo sapiens
Ligand
Function
fasiglifam
Agonist (partial)
Reference
10.1073/PNAS.2219569120

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Ligand Amino Acid Generic Number Segment Interaction Type
fasiglifam P80 3.26x26 TM3 Van der Waals
fasiglifam V81 3.27x27 TM3 Van der Waals
fasiglifam A83 3.29x29 TM3 hydrophobic
fasiglifam V84 3.30x30 TM3 hydrophobic
fasiglifam F87 3.33x33 TM3 hydrophobic
fasiglifam Y91 3.37x37 TM3 Van der Waals
fasiglifam L138 4.57x57 TM4 hydrophobic
fasiglifam G139 4.58x58 TM4 Van der Waals
fasiglifam V141 4.60x60 TM4 Van der Waals
fasiglifam F142 4.61x61 TM4 hydrophobic
fasiglifam F142 4.61x61 TM4 aromatic (edge-to-face)
fasiglifam L158 ECL2 Van der Waals
fasiglifam L171 45.51x51 ECL2 hydrophobic
fasiglifam R183 5.39x40 TM5 polar (hydrogen bond)
fasiglifam R183 5.39x40 TM5 polar (charge-charge)
fasiglifam L186 5.42x43 TM5 Van der Waals
fasiglifam R258 7.35x34 TM7 polar (charge-charge)

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Snake plot — Download: PNG | SVG
ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
Helix box plot — Download: PNG | SVG V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7

GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x26 3.26x26 P80
3x27 3.27x27 V81
3x29 3.29x29 A83
3x30 3.30x30 V84
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x57 4.57x57 L138
4x58 4.58x58 G139
4x60 4.60x60 V141
4x61 4.61x61 F142
ECL2
45x51 45.51x51 L171
TM5
5x40 5.39x40 R183
5x43 5.42x43 L186
TM7
7x34 7.35x34 R258