LPA5 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

20ZX

RESOLUTION

3.0 Å

REFERENCE

10.1073/PNAS.2537482123

PUBLICATION DATE

June 17, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

LYSOPHOSPHATIDIC ACID - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

LPA, N-arachidonoylglycine, farnesyl monophosphate, farnesyl diphosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 G 303 8x49 G.H5 V 361 G.H5.26
Polar ICL2 R 133 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 133 - G.H5 N 354 G.H5.19
Van-der-waals TM2 S 58 2x40 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL2 L 127 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 L 127 - G.H5 K 347 G.H5.12
Hydrophobic ICL1 L 51 - G.H5 L 360 G.H5.25
Polar TM2 V 57 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 V 57 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 V 57 2x39 G.H5 E 357 G.H5.22
Polar ICL2 R 130 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 E 302 8x48 G.H5 V 361 G.H5.26
Hydrophobic ICL1 V 53 - G.H5 V 361 G.H5.26
Van-der-waals ICL1 V 53 - G.H5 V 361 G.H5.26
Hydrophobic ICL2 L 127 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 127 - G.H5 F 343 G.H5.08
Hydrophobic TM2 S 55 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 S 55 2x37 G.H5 E 357 G.H5.22
Polar TM3 R 119 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 126 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 126 - G.H5 I 350 G.H5.15
Hydrophobic TM6 R 228 6x29 G.H5 L 355 G.H5.20
Polar TM6 R 228 6x29 G.h4s6 G 322 G.h4s6.11
Hydrophobic TM6 R 228 6x29 G.h4s6 G 322 G.h4s6.11
Van-der-waals TM6 R 228 6x29 G.h4s6 G 322 G.h4s6.11
Hydrophobic H8 A 301 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 A 301 8x47 G.H5 N 359 G.H5.24
Hydrophobic ICL2 R 130 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 R 130 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 H 131 - G.hns1 R 32 G.hns1.03
Polar TM6 S 226 6x27 G.H5 Q 352 G.H5.17
Polar TM2 V 56 2x38 G.H5 E 357 G.H5.22
Hydrophobic ICL3 T 224 - G.H5 D 348 G.H5.13
Hydrophobic TM1 F 47 1x57 G.H5 L 360 G.H5.25
Polar H8 E 302 8x48 G.H5 N 359 G.H5.24
Hydrophobic H8 G 303 8x49 G.H5 L 360 G.H5.25
Van-der-waals H8 G 303 8x49 G.H5 L 360 G.H5.25
Hydrophobic TM2 V 57 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 V 57 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM2 M 61 2x43 G.H5 L 360 G.H5.25
Van-der-waals TM2 M 61 2x43 G.H5 L 360 G.H5.25
Polar TM3 D 118 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 Y 358 G.H5.23
Polar ICL3 T 224 - G.H5 Q 352 G.H5.17
Van-der-waals ICL3 T 224 - G.H5 Q 352 G.H5.17
Hydrophobic ICL2 L 127 - G.S3 V 194 G.S3.01
Hydrophobic TM5 T 217 5x64 G.H5 L 351 G.H5.16
Hydrophobic TM4 R 134 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL1 V 53 - G.H5 L 360 G.H5.25
Van-der-waals ICL1 V 53 - G.H5 L 360 G.H5.25
Polar H8 G 303 8x49 G.H5 N 359 G.H5.24
Van-der-waals H8 G 303 8x49 G.H5 N 359 G.H5.24
Polar TM6 R 228 6x29 G.H5 Q 352 G.H5.17
Ionic ICL2 R 133 - G.H5 E 357 G.H5.22
Polar ICL2 R 133 - G.H5 E 357 G.H5.22
Van-der-waals ICL2 R 133 - G.H5 E 357 G.H5.22
Hydrophobic ICL2 L 127 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 127 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 R 130 - G.H5 I 350 G.H5.15
Hydrophobic TM6 R 228 6x29 G.H5 R 356 G.H5.21
Van-der-waals TM6 R 228 6x29 G.H5 R 356 G.H5.21
Hydrophobic TM5 L 218 5x65 G.H5 L 351 G.H5.16
Hydrophobic H8 F 304 8x50 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 127 - G.H5 C 346 G.H5.11
Polar ICL2 R 130 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 P 126 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 P 126 - G.H5 K 347 G.H5.12
Hydrophobic ICL2 L 127 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 127 - G.S1 L 34 G.S1.02
Hydrophobic TM6 T 232 6x33 G.H5 L 355 G.H5.20
Hydrophobic ICL2 P 126 - G.H5 L 351 G.H5.16
Hydrophobic H8 A 301 8x47 G.H5 L 360 G.H5.25
Van-der-waals H8 A 301 8x47 G.H5 L 360 G.H5.25
Polar TM3 A 122 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 354 G.H5.19
Polar ICL2 R 130 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 130 - G.hns1 R 31 G.hns1.02