D1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F0T

RESOLUTION

3.1 Å

REFERENCE

10.1126/SCIADV.ABO4158

PUBLICATION DATE

June 15, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

dopamine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline, 5-hydroxytryptamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 274 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 125 3x54 G.H5 Y 391 G.H5.23
Ionic TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 227 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 235 5x79 G.H4 R 347 G.H4.17
Ionic TM6 K 269 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 269 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 269 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 269 6x32 G.H5 E 392 G.H5.24
Polar TM3 S 126 3x55 G.H5 R 380 G.H5.12
Polar TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Polar TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 217 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 217 5x61 G.H5 L 393 G.H5.25
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 228 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 228 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 225 5x69 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 224 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Van-der-waals TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 A 238 5x82 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 238 5x82 G.H4 R 347 G.H4.17
Ionic ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Polar ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 L 231 5x75 G.H4 L 346 G.H4.16
Hydrophobic ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 228 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 E 232 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 221 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 235 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM5 Q 224 5x68 G.H5 L 388 G.H5.20
Aromatic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 221 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 221 5x65 G.H5 L 388 G.H5.20
Polar TM6 T 273 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 217 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 231 5x75 G.S6 P 361 G.S6.03
Polar TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 270 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 239 5x83 G.H4 R 347 G.H4.17
Polar TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Polar ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Polar TM5 Q 224 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 V 270 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 C 241 5x85 G.hgh4 T 319 G.hgh4.09
Van-der-waals TM5 C 241 5x85 G.hgh4 T 319 G.hgh4.09
Hydrophobic ICL2 R 133 34x55 G.hns1 A 39 G.hns1.03
Aromatic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 238 5x82 G.H4 D 343 G.H4.13
Polar TM4 T 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 388 G.H5.20