ADGRG2 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YKD

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-025-01896-2

PUBLICATION DATE

Aug. 13, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

20 interactions (Click to see)

LIGANDS

PRASTERONE - Agonist chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 830 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 830 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 719 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 719 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 718 - G.H5 I 383 G.H5.15
Aromatic ICL2 Y 722 - G.s1h1 R 48 G.s1h1.02
Hydrophobic ICL2 Y 722 - G.s1h1 R 48 G.s1h1.02
Hydrophobic ICL2 F 719 - G.H2 F 229 G.H2.02
Polar TM3 L 715 3x58 G.H5 R 380 G.H5.12
Hydrophobic TM6 L 830 6x45 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 807 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 807 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 715 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM2 P 653 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 653 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 N 720 - G.s3h2 V 227 G.s3h2.03
Van-der-waals ICL2 N 720 - G.s3h2 V 227 G.s3h2.03
Hydrophobic ICL2 Y 722 - G.S1 Q 45 G.S1.06
Van-der-waals ICL2 Y 722 - G.S1 Q 45 G.S1.06
Polar TM3 V 716 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 716 3x59 G.H5 R 380 G.H5.12
Polar TM6 S 826 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 826 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 826 6x41 G.H5 L 393 G.H5.25
Polar TM3 A 714 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 714 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 714 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM2 P 653 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 P 653 2x46 G.H5 Q 390 G.H5.22
Polar ICL2 Y 722 - G.S1 Q 41 G.S1.02
Van-der-waals ICL2 Y 722 - G.S1 Q 41 G.S1.02
Hydrophobic TM5 I 807 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM2 D 651 2x44 G.H5 Q 390 G.H5.22
Van-der-waals TM2 D 651 2x44 G.H5 Q 390 G.H5.22
Polar ICL3 K 810 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 719 - G.s3h2 V 227 G.s3h2.03
Van-der-waals ICL2 F 719 - G.s3h2 V 227 G.s3h2.03
Polar ICL2 N 720 - G.s3h2 K 226 G.s3h2.02
Hydrophobic TM5 L 804 5x61 G.H5 L 388 G.H5.20
Aromatic ICL2 Y 722 - G.S1 K 44 G.S1.05
Hydrophobic ICL2 Y 722 - G.S1 K 44 G.S1.05
Van-der-waals ICL2 Y 722 - G.S1 K 44 G.S1.05
Polar TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 M 711 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 711 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 719 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 719 - G.H5 I 383 G.H5.15
Hydrophobic TM5 L 804 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 718 - G.H5 R 380 G.H5.12
Aromatic ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Hydrophobic ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Van-der-waals ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Hydrophobic TM3 L 715 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 719 - G.H5 C 379 G.H5.11
Polar TM5 Q 803 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 803 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 803 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 807 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 724 - G.S1 Q 45 G.S1.06
Van-der-waals ICL2 R 724 - G.S1 Q 45 G.S1.06
Hydrophobic TM6 S 826 6x41 G.H5 E 392 G.H5.24
Hydrophobic TM7 Y 871 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 833 6x48 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 719 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 719 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 719 - G.H5 F 376 G.H5.08
Hydrophobic TM5 V 800 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 H 710 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 710 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 718 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 718 - G.H5 Q 384 G.H5.16