PDB
8YKD
Resolution
2.9 Å
Released
Aug. 13, 2025
Receptor
ADGRG2
Class
B2
Species
Mus musculus
Ligand
PRASTERONE
Function
Agonist
Reference
10.1038/S41589-025-01896-2

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
PRASTERONE L667 2.60x60 TM2 hydrophobic
PRASTERONE N668 2.61x61 TM2 polar (hydrogen bond)
PRASTERONE N668 2.61x61 TM2 Van der Waals
PRASTERONE F671 2.64x64 TM2 hydrophobic
PRASTERONE F671 2.64x64 TM2 Van der Waals
PRASTERONE W838 6.53x53 TM6 Van der Waals
PRASTERONE W838 6.53x53 TM6 hydrophobic
PRASTERONE F856 7.42x41 TM7 hydrophobic
PRASTERONE F856 7.42x41 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 E K I R R ICL1ECL1 N ECL1ICL2 V F N T Y I R ICL2ECL2 P D N Y G I G S Y G K F P N G T P D D F C W I N S ECL2ICL3 Q L G A Q R K ICL3ECL3 P V N ECL3N-term M L F S G G Q Y S P V G R P E E V L L I Y K I F L V I I C F H V I L V T S L K E N G N S S L L S P S A E S S L V S L I P Y S N G T P D A A S E V L S T L N K T E K S K I T I V K T F N A S G V K S Q R N I C N L S S L C N D S V F F R G E I V F Q H D E D H N V T Q N Q D T A N G T F A G V L S L S E L K R S E L N K T L Q T L S E T Y F I V C A T A E A Q S T V N C T F T V K L N E T M N V C A M M V T F Q T V Q I R P M E Q C C C S P R T P C P S S P E E L E K L Q C E L Q D P I V C L A D Q P H G P P L S S S S K P V V P Q A T I I S H V A S D F S L A E P L D H A L M T P S T P S L T Q E S N L P S P Q P T I P L A S S P A T D L P V Q S V V V S S L P Q T D L S H T L S P V Q S S I P S P T T P A P S V P T E L V T I S T P P G E T V V N T S T V S D L E A Q V S Q M E K A L S L G S L E P N L A G E M V N R V S K L L H S P P A L L A P L A Q R L L K V V D A I G L Q L N F S S T T I S L T S P S L A L A V I R V N A S N F N T T T F A A Q D P T N L Q V S L E T P P P E N S I G A I T L P S S L M N N L P A N D V E L A S R I Q F N F F E T P A L F Q D P S L E N L T L I S Y V I S S S V T N M T I K N L T R N V T V A L K H I N P S P D D L T V K C V F W D L G R N G G K G G W S S D G C S V K D K R M N E T I C T C S H L T S F G I L L D L S R T S L P N-termC-term R L A E N S D W S K T A T N G L K K Q T V N Q G V S S S S N S L Q S S C N S T N S T T L L V N S D C S V H A S G N G N A S T E R N G V S F S V Q N G D V C L H D L T G K Q H M F S D K E D S C N G K S R I A L R R T S K R G S L H F I E Q M C-term P S Q M M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K K Y I L K F C I V G W G I P A V V V S I V L T I S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K T S I Q D L R S I A G L T F L L G I T W G F A F F A W G V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N W R R G K L V R K Q Y L C C
Helix box plot — Download: PNG | SVG S L F I S S L G C G I Y T I F T L A M M 1 I Q L C A A L L L L N L I F L L D S W I 2 L G M W T F S V L L F Y H L F V A V A I 3 Y I L K F C I G V W G I P A V V V S I V L 4 F M S V N L L F I V C F Y G V V T I Y F V 5 A G L T F L L G I T W G F A F F A W G 6 I F I F F G Q L T N F I A F L Y M F T 7

GPCRdb(A)
GPCRdb(B)
ADGRG2
TM2
2x53 2.60x60 L667
2x54 2.61x61 N668
2x57 2.64x64 F671
TM6
6x48 6.53x53 W838
TM7
7x37 7.42x41 F856