PDB
8YKD
Resolution
2.9 Å
Released
Aug. 13, 2025
Receptor
ADGRG2
Class
B2
Species
Mus musculus
Ligand
Function
PRASTERONE
Agonist
Reference
10.1038/S41589-025-01896-2

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Ligand Amino Acid Generic Number Segment Interaction Type
PRASTERONE T624 1.43x43 TM1 hydrophobic
PRASTERONE C628 1.47x47 TM1 Van der Waals
PRASTERONE L667 2.60x60 TM2 Van der Waals
PRASTERONE N668 2.61x61 TM2 polar (hydrogen bond)
PRASTERONE F671 2.64x64 TM2 hydrophobic
PRASTERONE W838 6.53x53 TM6 hydrophobic
PRASTERONE F856 7.42x41 TM7 hydrophobic
PRASTERONE N860 7.46x45 TM7 Van der Waals
PRASTERONE T861 7.47x46 TM7 Van der Waals

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ICL1 E K I R R ICL1ECL1 N ECL1ICL2 V F N T Y I R ICL2ECL2 P D N Y G I G S Y G K F P N G T P D D F C W I N S ECL2ICL3 Q L G A Q R K ICL3ECL3 P V N ECL3N-term M L F S G G Q Y S P V G R P E E V L L I Y K I F L V I I C F H V I L V T S L K E N G N S S L L S P S A E S S L V S L I P Y S N G T P D A A S E V L S T L N K T E K S K I T I V K T F N A S G V K S Q R N I C N L S S L C N D S V F F R G E I V F Q H D E D H N V T Q N Q D T A N G T F A G V L S L S E L K R S E L N K T L Q T L S E T Y F I V C A T A E A Q S T V N C T F T V K L N E T M N V C A M M V T F Q T V Q I R P M E Q C C C S P R T P C P S S P E E L E K L Q C E L Q D P I V C L A D Q P H G P P L S S S S K P V V P Q A T I I S H V A S D F S L A E P L D H A L M T P S T P S L T Q E S N L P S P Q P T I P L A S S P A T D L P V Q S V V V S S L P Q T D L S H T L S P V Q S S I P S P T T P A P S V P T E L V T I S T P P G E T V V N T S T V S D L E A Q V S Q M E K A L S L G S L E P N L A G E M V N R V S K L L H S P P A L L A P L A Q R L L K V V D A I G L Q L N F S S T T I S L T S P S L A L A V I R V N A S N F N T T T F A A Q D P T N L Q V S L E T P P P E N S I G A I T L P S S L M N N L P A N D V E L A S R I Q F N F F E T P A L F Q D P S L E N L T L I S Y V I S S S V T N M T I K N L T R N V T V A L K H I N P S P D D L T V K C V F W D L G R N G G K G G W S S D G C S V K D K R M N E T I C T C S H L T S F G I L L D L S R T S L P N-termC-term R L A E N S D W S K T A T N G L K K Q T V N Q G V S S S S N S L Q S S C N S T N S T T L L V N S D C S V H A S G N G N A S T E R N G V S F S V Q N G D V C L H D L T G K Q H M F S D K E D S C N G K S R I A L R R T S K R G S L H F I E Q M C-term P S Q M M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K K Y I L K F C I V G W G I P A V V V S I V L T I S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K T S I Q D L R S I A G L T F L L G I T W G F A F F A W G V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N W R R G K L V R K Q Y L C C
Helix box plot — Download: PNG | SVG S L F I S S L G C G I Y T I F T L A M M 1 I Q L C A A L L L L N L I F L L D S W I 2 L G M W T F S V L L F Y H L F V A V A I 3 Y I L K F C I G V W G I P A V V V S I V L 4 F M S V N L L F I V C F Y G V V T I Y F V 5 A G L T F L L G I T W G F A F F A W G 6 I F I F F G Q L T N F I A F L Y M F T 7

GPCRdb(A)
GPCRdb(B)
ADGRG2
TM1
1x39 1.43x43 T624
1x43 1.47x47 C628
TM2
2x53 2.60x60 L667
2x54 2.61x61 N668
2x57 2.64x64 F671
TM6
6x48 6.53x53 W838
TM7
7x37 7.42x41 F856
7x41 7.46x45 N860
7x42 7.47x46 T861