A2A receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

April 9, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Hydrophobic ICL3 M 211 - G.H5 R 375 G.H5.17
Van-der-waals ICL3 M 211 - G.H5 R 375 G.H5.17
Polar TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Van-der-waals TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM3 A 105 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 105 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 109 34x50 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 L 110 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 110 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL3 E 212 - G.H5 R 375 G.H5.17
Hydrophobic ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 106 3x54 G.H5 Y 381 G.H5.23
Van-der-waals TM3 I 106 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 110 34x51 G.H5 C 369 G.H5.11
Hydrophobic TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 I 106 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL2 L 110 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 110 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL2 L 110 34x51 G.H5 R 370 G.H5.12
Van-der-waals ICL2 L 110 34x51 G.H5 R 370 G.H5.12
Polar TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Aromatic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 R 111 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 109 34x50 G.H5 H 377 G.H5.19
Hydrophobic TM5 I 200 5x61 G.H5 Y 381 G.H5.23
Van-der-waals TM5 I 200 5x61 G.H5 Y 381 G.H5.23
Hydrophobic TM5 A 204 5x65 G.H5 L 378 G.H5.20
Hydrophobic ICL4 I 292 - G.H5 E 382 G.H5.24
Van-der-waals ICL4 I 292 - G.H5 E 382 G.H5.24
Polar ICL2 N 113 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 N 113 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 N 113 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 110 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 110 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 110 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 109 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 109 34x50 G.H5 I 373 G.H5.15