PDB
9EEA
Resolution
3.4 Å
Released
April 9, 2025
Receptor
A2A
Class
A
Species
Homo sapiens
Ligand
adenosine
Function
Agonist
Reference
10.1038/S41467-025-56434-4

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Ligand Amino Acid Generic Number Segment Interaction Type
adenosine V84 3.32x32 TM3 polar (hydrogen bond)
adenosine T88 3.36x36 TM3 polar (hydrogen bond)
adenosine F168 45.52x52 ECL2 polar (hydrogen bond)
adenosine F168 45.52x52 ECL2 aromatic (edge-to-face)
adenosine M177 5.38x40 TM5 polar (hydrogen bond)
adenosine W246 6.48x48 TM6 polar (hydrogen bond)
adenosine L249 6.51x51 TM6 polar (hydrogen bond)
adenosine H250 6.52x52 TM6 Van der Waals
adenosine N253 6.55x55 TM6 polar (hydrogen bond)
adenosine N253 6.55x55 TM6 polar (hydrogen bond)
adenosine M270 7.35x34 TM7 polar (hydrogen bond)
adenosine I274 7.39x38 TM7 polar (hydrogen bond)
adenosine S277 7.42x41 TM7 polar (hydrogen bond)
adenosine H278 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
Helix box plot — Download: PNG | SVG V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7

GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
3x36 3.36x36 T88
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
7x41 7.42x41 S277
7x42 7.43x42 H278