A2A receptor (aa2ar_human)
FAMILY
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors A2A receptor
GENE
ADORA2A (ADORA2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adenosine receptor A2a
SOURCE
SWISSPROT
SEQUENCE
TM1 | |||||||||
M
|
P
|
I
|
M
|
G
|
S
|
S
|
V
|
Y
|
I
|
10 |
T
|
V
|
E
|
L
|
A
|
I
|
A
|
V
|
L
|
A
|
20 |
I
|
L
|
G
|
N
|
V
|
L
|
V
|
C
|
W
|
A
|
30 |
ICL1 | |||||||||
V
|
W
|
L
|
N
|
S
|
N
|
L
|
Q
|
N
|
V
|
40 |
TM2 | |||||||||
T
|
N
|
Y
|
F
|
V
|
V
|
S
|
L
|
A
|
A
|
50 |
A
|
D
|
I
|
A
|
V
|
G
|
V
|
L
|
A
|
I
|
60 |
P
|
F
|
A
|
I
|
T
|
I
|
S
|
T
|
G
|
F
|
70 |
ECL1 | TM3 | ||||||||
C
|
A
|
A
|
C
|
H
|
G
|
C
|
L
|
F
|
I
|
80 |
A
|
C
|
F
|
V
|
L
|
V
|
L
|
T
|
Q
|
S
|
90 |
S
|
I
|
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
100 |
D
|
R
|
Y
|
I
|
A
|
I
|
R
|
I
|
P
|
L
|
110 |
ICL2 | TM4 | ||||||||
R
|
Y
|
N
|
G
|
L
|
V
|
T
|
G
|
T
|
R
|
120 |
A
|
K
|
G
|
I
|
I
|
A
|
I
|
C
|
W
|
V
|
130 |
L
|
S
|
F
|
A
|
I
|
G
|
L
|
T
|
P
|
M
|
140 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
N
|
C
|
G
|
Q
|
P
|
K
|
150 |
E
|
G
|
K
|
N
|
H
|
S
|
Q
|
G
|
C
|
G
|
160 |
E
|
G
|
Q
|
V
|
A
|
C
|
L
|
F
|
E
|
D
|
170 |
TM5 | |||||||||
V
|
V
|
P
|
M
|
N
|
Y
|
M
|
V
|
Y
|
F
|
180 |
N
|
F
|
F
|
A
|
C
|
V
|
L
|
V
|
P
|
L
|
190 |
L
|
L
|
M
|
L
|
G
|
V
|
Y
|
L
|
R
|
I
|
200 |
F
|
L
|
A
|
A
|
R
|
R
|
Q
|
L
|
K
|
Q
|
210 |
ICL3 | |||||||||
M
|
E
|
S
|
Q
|
P
|
L
|
P
|
G
|
E
|
R
|
220 |
TM6 | |||||||||
A
|
R
|
S
|
T
|
L
|
Q
|
K
|
E
|
V
|
H
|
230 |
A
|
A
|
K
|
S
|
L
|
A
|
I
|
I
|
V
|
G
|
240 |
L
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
L
|
H
|
250 |
I
|
I
|
N
|
C
|
F
|
T
|
F
|
F
|
C
|
P
|
260 |
ECL3 | TM7 | ||||||||
D
|
C
|
S
|
H
|
A
|
P
|
L
|
W
|
L
|
M
|
270 |
Y
|
L
|
A
|
I
|
V
|
L
|
S
|
H
|
T
|
N
|
280 |
S
|
V
|
V
|
N
|
P
|
F
|
I
|
Y
|
A
|
Y
|
290 |
H8 | |||||||||
R
|
I
|
R
|
E
|
F
|
R
|
Q
|
T
|
F
|
R
|
300 |
K
|
I
|
I
|
R
|
S
|
H
|
V
|
L
|
R
|
Q
|
310 |
C-term | |||||||||
Q
|
E
|
P
|
F
|
K
|
A
|
A
|
G
|
T
|
S
|
320 |
A
|
R
|
V
|
L
|
A
|
A
|
H
|
G
|
S
|
D
|
330 |
G
|
E
|
Q
|
V
|
S
|
L
|
R
|
L
|
N
|
G
|
340 |
H
|
P
|
P
|
G
|
V
|
W
|
A
|
N
|
G
|
S
|
350 |
A
|
P
|
H
|
P
|
E
|
R
|
R
|
P
|
N
|
G
|
360 |
Y
|
A
|
L
|
G
|
L
|
V
|
S
|
G
|
G
|
S
|
370 |
A
|
Q
|
E
|
S
|
Q
|
G
|
N
|
T
|
G
|
L
|
380 |
P
|
D
|
V
|
E
|
L
|
L
|
S
|
H
|
E
|
L
|
390 |
K
|
G
|
V
|
C
|
P
|
E
|
P
|
P
|
G
|
L
|
400 |
D
|
D
|
P
|
L
|
A
|
Q
|
D
|
G
|
A
|
G
|
410 |
V
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
adenosine
STRUCTURE MODELS
STRUCTURES
Found 79 structure(s) - view all details on the Structures page
PDBs: 3EML, 3QAK, 2YDO, 2YDV, 3PWH, 3REY, 3RFM, 3VG9, 3VGA, 3UZA, 3UZC, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IU8, 5IUA, 5IUB, 5G53, 5K2A, 5K2B, 5K2C, 5K2D, 5UIG, 5UVI, 5JTB, 5MZJ, 5MZP, 5N2R, 5NLX, 5NM2, 5NM4, 5VRA, 6AQF, 5OLG, 5OLH, 5OLO, 5OLV, 5OLZ, 5OM1, 5OM4, 5WF5, 5WF6, 6GDG, 6MH8, 6GT3, 6JZH, 6PS7, 6S0L, 6S0Q, 6ZDR, 6ZDV, 6WQA, 6LPJ, 6LPK, 6LPL, 7ARO, 7RM5, 7PX4, 7PYR, 7EZC, 7T32, 8CU6, 8CU7, 8DU3, 8FYN, 8GNE, 8GNG, 8CIC, 8C9W, 8JWY, 8JWZ, 8A2O, 8A2P, 8PWN, 8RLN, 8RQQ, 8WDT