H4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YFC

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41467-023-42260-Z

PUBLICATION DATE

Oct. 25, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

11 interactions (Click to see)

LIGANDS

histamine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank gtoplig

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 54 2x43 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 Y 122 34x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 V 116 3x54 G.H5 L 360 G.H5.25
Hydrophobic ICL2 A 119 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 A 119 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 T 124 34x55 G.hns1 R 31 G.hns1.02
Ionic ICL2 R 123 34x54 G.H5 E 357 G.H5.22
Polar ICL2 R 123 34x54 G.H5 E 357 G.H5.22
Van-der-waals ICL2 R 123 34x54 G.H5 E 357 G.H5.22
Polar ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 124 34x55 G.S1 L 34 G.S1.02
Van-der-waals ICL2 T 124 34x55 G.S1 L 34 G.S1.02
Ionic H8 R 364 8x49 G.H5 E 357 G.H5.22
Van-der-waals TM7 C 361 7x56 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 A 119 34x50 G.H5 L 351 G.H5.16
Van-der-waals ICL2 A 119 34x50 G.H5 L 351 G.H5.16
Polar ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 S 50 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 Y 358 G.H5.23
Polar ICL2 T 127 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 T 127 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 T 127 - G.HN Q 28 G.HN.52
Hydrophobic TM3 R 112 3x50 G.H5 L 360 G.H5.25
Hydrophobic ICL2 R 123 34x54 G.H5 I 350 G.H5.15
Van-der-waals ICL2 R 123 34x54 G.H5 I 350 G.H5.15
Polar ICL4 K 363 - G.H5 E 357 G.H5.22
Hydrophobic ICL4 K 363 - G.H5 E 357 G.H5.22
Van-der-waals ICL4 K 363 - G.H5 E 357 G.H5.22
Hydrophobic TM7 C 361 7x56 G.H5 N 359 G.H5.24
Van-der-waals TM7 C 361 7x56 G.H5 N 359 G.H5.24
Polar ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Van-der-waals ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Hydrophobic TM5 I 197 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 360 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.H5 I 350 G.H5.15
Polar ICL4 H 362 - G.H5 E 357 G.H5.22
Hydrophobic ICL4 H 362 - G.H5 E 357 G.H5.22
Van-der-waals ICL4 H 362 - G.H5 E 357 G.H5.22
Hydrophobic ICL2 R 123 34x54 G.H5 M 353 G.H5.18
Polar TM3 S 115 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 V 120 34x51 G.H5 K 347 G.H5.12
Hydrophobic ICL4 K 363 - G.H5 N 359 G.H5.24
Polar ICL2 H 126 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 116 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 L 351 G.H5.16
Polar ICL2 A 119 34x50 G.H5 N 354 G.H5.19
Hydrophobic ICL2 A 119 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 A 119 34x50 G.H5 N 354 G.H5.19
Polar TM3 D 111 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM6 L 301 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM3 S 115 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 201 5x65 G.H5 V 361 G.H5.26
Aromatic ICL4 H 362 - G.H5 Y 358 G.H5.23
Hydrophobic ICL4 H 362 - G.H5 Y 358 G.H5.23
Polar ICL4 K 363 - G.H5 R 356 G.H5.21
Van-der-waals ICL4 K 363 - G.H5 R 356 G.H5.21
Hydrophobic TM3 V 116 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 355 G.H5.20