motilin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9JMD

RESOLUTION

2.7 Å

REFERENCE

10.1016/J.CELREP.2025.115329

PUBLICATION DATE

May 28, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

62 interactions (Click to see)

LIGANDS

azithromycin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

motilin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 140 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM3 I 140 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 I 140 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM3 I 140 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 I 140 3x54 G.H5 L 360 G.H5.25
Hydrophobic H8 S 359 8x47 G.H5 V 361 G.H5.26
Polar H8 S 359 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 359 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 359 8x47 G.H5 N 359 G.H5.24
Polar ICL2 R 147 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 147 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 144 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 L 144 - G.H5 K 347 G.H5.12
Polar TM7 Y 355 7x53 G.H5 N 359 G.H5.24
Van-der-waals TM7 Y 355 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM7 I 358 7x56 G.H5 V 361 G.H5.26
Van-der-waals TM7 I 358 7x56 G.H5 V 361 G.H5.26
Hydrophobic ICL2 L 144 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 L 144 - G.S3 V 194 G.S3.01
Hydrophobic TM3 I 140 3x54 G.H5 N 354 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 354 G.H5.19
Van-der-waals TM7 N 356 7x54 G.H5 N 359 G.H5.24
Hydrophobic TM6 L 300 6x37 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 149 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 149 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 144 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 144 - G.H5 I 350 G.H5.15
Ionic ICL2 R 145 - G.s2s3 D 192 G.s2s3.01
Polar ICL2 R 145 - G.s2s3 D 192 G.s2s3.01
Hydrophobic ICL2 R 145 - G.s2s3 D 192 G.s2s3.01
Van-der-waals ICL2 R 145 - G.s2s3 D 192 G.s2s3.01
Hydrophobic TM5 L 274 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 L 274 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM5 L 274 5x65 G.H5 L 351 G.H5.16
Van-der-waals TM5 L 274 5x65 G.H5 L 351 G.H5.16
Hydrophobic TM2 T 73 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 73 2x39 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 144 - G.H5 C 346 G.H5.11
Hydrophobic ICL2 R 147 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 R 147 - G.S1 L 34 G.S1.02
Hydrophobic TM2 T 73 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 73 2x39 G.H5 E 357 G.H5.22
Hydrophobic ICL2 L 144 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 144 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 L 144 - G.H5 F 343 G.H5.08
Polar TM2 T 71 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 71 2x37 G.H5 E 357 G.H5.22
Hydrophobic ICL2 R 145 - G.S3 V 194 G.S3.01
Hydrophobic TM3 R 136 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 360 G.H5.25
Polar TM3 R 136 3x50 G.H5 N 359 G.H5.24
Van-der-waals TM3 R 136 3x50 G.H5 N 359 G.H5.24
Polar TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Hydrophobic TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Van-der-waals TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 R 145 - G.s2s3 K 193 G.s2s3.02
Van-der-waals ICL2 R 145 - G.s2s3 K 193 G.s2s3.02
Polar TM3 A 139 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM2 T 73 2x39 G.H5 N 359 G.H5.24
Van-der-waals TM2 T 73 2x39 G.H5 N 359 G.H5.24
Hydrophobic ICL2 L 149 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 149 - G.hns1 R 32 G.hns1.03
Ionic H8 K 361 8x49 G.H5 E 357 G.H5.22
Polar H8 K 361 8x49 G.H5 E 357 G.H5.22
Van-der-waals H8 K 361 8x49 G.H5 E 357 G.H5.22
Hydrophobic TM3 A 139 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 Y 358 G.H5.23
Hydrophobic H8 K 360 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 K 360 8x48 G.H5 V 361 G.H5.26
Polar TM6 T 296 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 T 296 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 T 296 6x33 G.H5 L 360 G.H5.25
Polar TM3 R 136 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 149 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 L 149 - G.HN Q 28 G.HN.52
Polar ICL2 R 147 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 147 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 E 273 5x64 G.H5 L 351 G.H5.16
Van-der-waals TM5 E 273 5x64 G.H5 L 351 G.H5.16
Van-der-waals TM2 L 77 2x43 G.H5 N 359 G.H5.24
Polar TM2 N 74 2x40 G.H5 N 359 G.H5.24