Refined structure (8U26) of Gs - NK1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-07-12

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (54.8%), 178 from model (45.2%)
Residue sidechains - 176 from structure (44.7%), 218 from model (55.3%)

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (86.1%), 46 from model (13.9%)
Residue sidechains - 275 from structure (83.3%), 55 from model (16.7%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
H02G.S1A14G.hgh4R12Y23E24G.H5GproteinN2x40R-D5x73I3x55L-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S1G.hgh4G.H5GPCR segments:TM2ICL2TM3TM5

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null12x502x392x403x493x503x533x543x555x655x736x266x296x306x326x337x568x478x498x50G.H5.26G.H5.25G.H5.24G.H5.23G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.11G.H5.08G.H4.12G.hgh4.14G.hgh4.13G.S3.03G.S3.01G.S1.02G.hns1.03G.hns1.02Res. Pos.NK1 (8U26_REFINED)- (8U26_REFINED)--------------------MTNDRAIILDQAKKVLNRFMTNDRAIILDQAKKVLNRFLEYLHQLRRDARLRFCIHVFRA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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