Refined structure (8TYW) of Gs - GPR6

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2025-03-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 237 from structure (60.2%), 157 from model (39.8%)
Residue sidechains - 221 from structure (56.1%), 173 from model (43.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 Structure AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure AF2
G.H1 62 I G.H1.10 Structure AF2
G.H1 63 L G.H1.11 Structure AF2
G.H1 64 H G.H1.12 Structure AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure AF2
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure AF2
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 263 from structure (74.1%), 92 from model (25.9%)
Residue sidechains - 261 from structure (73.5%), 94 from model (26.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 A - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 Q - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 A - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 G - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 D - AF2 AF2
N-term 33 T - AF2 AF2
N-term 34 G - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 W - AF2 AF2
N-term 37 G - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 P - AF2 AF2
N-term 40 A - AF2 AF2
N-term 41 A - AF2 AF2
N-term 42 A - AF2 AF2
N-term 43 A - AF2 AF2
N-term 44 L - AF2 AF2
N-term 45 G - AF2 AF2
N-term 46 A - AF2 AF2
N-term 47 G - AF2 AF2
N-term 48 G - AF2 AF2
N-term 49 G - AF2 AF2
N-term 50 A - AF2 AF2
N-term 51 N - AF2 AF2
N-term 52 G - AF2 AF2
N-term 53 S - AF2 AF2
N-term 54 L - AF2 AF2
N-term 55 E - AF2 AF2
N-term 56 L - AF2 AF2
N-term 57 S - AF2 AF2
N-term 58 S - AF2 AF2
N-term 59 Q - AF2 AF2
N-term 60 L - AF2 AF2
N-term 61 S - AF2 AF2
N-term 62 A - AF2 AF2
N-term 63 G - AF2 AF2
N-term 64 P - AF2 AF2
N-term 65 P - AF2 AF2
N-term 66 G - AF2 AF2
N-term 67 L - AF2 AF2
N-term 68 L - AF2 AF2
N-term 69 L - AF2 AF2
N-term 70 P - AF2 AF2
TM1 71 A 1.31x31 AF2 AF2
TM1 72 V 1.32x32 AF2 AF2
TM1 73 N 1.33x33 Structure Structure
TM1 74 P 1.34x34 Structure Structure
TM1 75 W 1.35x35 Structure Structure
TM1 76 D 1.36x36 Structure Structure
TM1 77 V 1.37x37 Structure Structure
TM1 78 L 1.38x38 Structure Structure
TM1 79 L 1.39x39 Structure Structure
TM1 80 C 1.40x40 Structure Structure
TM1 81 V 1.41x41 Structure Structure
TM1 82 S 1.42x42 Structure Structure
TM1 83 G 1.43x43 Structure Structure
TM1 84 T 1.44x44 Structure Structure
TM1 85 V 1.45x45 Structure Structure
TM1 86 I 1.46x46 Structure Structure
TM1 87 A 1.47x47 Structure Structure
TM1 88 G 1.48x48 Structure Structure
TM1 89 E 1.49x49 Structure Structure
TM1 90 N 1.50x50 Structure Structure
TM1 91 A 1.51x51 Structure Structure
TM1 92 L 1.52x52 Structure Structure
TM1 93 V 1.53x53 Structure Structure
TM1 94 V 1.54x54 Structure Structure
TM1 95 A 1.55x55 Structure Structure
TM1 96 L 1.56x56 Structure Structure
TM1 97 I 1.57x57 Structure Structure
TM1 98 A 1.58x58 Structure Structure
TM1 99 S 1.59x59 Structure Structure
TM1 100 T 1.60x60 Structure Structure
ICL1 101 P 12.48x48 Structure Structure
ICL1 102 A 12.49x49 Structure Structure
ICL1 103 L 12.50x50 Structure Structure
ICL1 104 R 12.51x51 Structure Structure
TM2 105 T 2.37x37 Structure Structure
TM2 106 P 2.38x38 Structure Structure
TM2 107 M 2.39x39 Structure Structure
TM2 108 F 2.40x40 Structure Structure
TM2 109 V 2.41x41 Structure Structure
TM2 110 L 2.42x42 Structure Structure
TM2 111 V 2.43x43 Structure Structure
TM2 112 G 2.44x44 Structure Structure
TM2 113 S 2.45x45 Structure Structure
TM2 114 L 2.46x46 Structure Structure
TM2 115 A 2.47x47 Structure Structure
TM2 116 T 2.48x48 Structure Structure
TM2 117 A 2.49x49 Structure Structure
TM2 118 D 2.50x50 Structure Structure
TM2 119 L 2.51x51 Structure Structure
TM2 120 L 2.52x52 Structure Structure
TM2 121 A 2.53x53 Structure Structure
TM2 122 G 2.54x54 Structure Structure
TM2 123 C 2.55x55 Structure Structure
TM2 124 G 2.56x56 Structure Structure
TM2 125 L 2.57x57 Structure Structure
TM2 126 I 2.58x58 Structure Structure
TM2 127 L 2.59x59 Structure Structure
TM2 128 H 2.60x60 Structure Structure
TM2 129 F 2.61x61 Structure Structure
TM2 130 V 2.62x62 Structure Structure
TM2 131 F 2.63x63 Structure Structure
TM2 132 Q 2.64x64 Structure Structure
TM2 133 Y 2.65x65 Structure Structure
ECL1 134 L - Structure Structure
ECL1 135 V - Structure Structure
ECL1 136 P - Structure Structure
TM3 137 S 3.21x21 Structure Structure
TM3 138 E 3.22x22 Structure Structure
TM3 139 T 3.23x23 Structure Structure
TM3 140 V 3.24x24 Structure Structure
TM3 141 S 3.25x25 Structure Structure
TM3 142 L 3.26x26 Structure Structure
TM3 143 L 3.27x27 Structure Structure
TM3 144 T 3.28x28 Structure Structure
TM3 145 V 3.29x29 Structure Structure
TM3 146 G 3.30x30 Structure Structure
TM3 147 F 3.31x31 Structure Structure
TM3 148 L 3.32x32 Structure Structure
TM3 149 V 3.33x33 Structure Structure
TM3 150 A 3.34x34 Structure Structure
TM3 151 S 3.35x35 Structure Structure
TM3 152 F 3.36x36 Structure Structure
TM3 153 A 3.37x37 Structure Structure
TM3 154 A 3.38x38 Structure Structure
TM3 155 S 3.39x39 Structure Structure
TM3 156 V 3.40x40 Structure Structure
TM3 157 S 3.41x41 Structure Structure
TM3 158 S 3.42x42 Structure Structure
TM3 159 L 3.43x43 Structure Structure
TM3 160 L 3.44x44 Structure Structure
TM3 161 A 3.45x45 Structure Structure
TM3 162 I 3.46x46 Structure Structure
TM3 163 T 3.47x47 Structure Structure
TM3 164 V 3.48x48 Structure Structure
TM3 165 D 3.49x49 Structure Structure
TM3 166 R 3.50x50 Structure Structure
TM3 167 Y 3.51x51 Structure Structure
TM3 168 L 3.52x52 Structure Structure
TM3 169 S 3.53x53 Structure Structure
TM3 170 L 3.54x54 Structure Structure
TM3 171 Y 3.55x55 Structure Structure
TM3 172 N 3.56x56 Structure Structure
ICL2 173 A 34.50x50 Structure Structure
ICL2 174 L 34.51x51 Structure Structure
ICL2 175 T 34.52x52 Structure Structure
ICL2 176 Y 34.53x53 Structure Structure
ICL2 177 Y 34.54x54 Structure Structure
TM4 178 S 4.35x35 Structure Structure
TM4 179 R 4.36x36 Structure Structure
TM4 180 R 4.37x37 Structure AF2
TM4 181 T 4.38x38 Structure Structure
TM4 182 L 4.39x39 Structure Structure
TM4 183 L 4.40x40 Structure Structure
TM4 184 G 4.41x41 Structure Structure
TM4 185 V 4.42x42 Structure Structure
TM4 186 H 4.43x43 Structure Structure
TM4 187 L 4.44x44 Structure Structure
TM4 188 L 4.45x45 Structure Structure
TM4 189 L 4.46x46 Structure Structure
TM4 190 A 4.47x47 Structure Structure
TM4 191 A 4.48x48 Structure Structure
TM4 192 T 4.49x49 Structure Structure
TM4 193 W 4.50x50 Structure Structure
TM4 194 T 4.51x51 Structure Structure
TM4 195 V 4.52x52 Structure Structure
TM4 196 S 4.53x53 Structure Structure
TM4 197 L 4.54x54 Structure Structure
TM4 198 G 4.55x55 Structure Structure
TM4 199 L 4.56x56 Structure Structure
TM4 200 G 4.57x57 Structure Structure
TM4 201 L 4.58x58 Structure Structure
TM4 202 L 4.59x59 Structure Structure
TM4 203 P 4.60x60 Structure Structure
TM4 204 V 4.61x61 Structure Structure
TM4 205 L 4.62x62 Structure Structure
TM4 206 G 4.63x63 Structure Structure
ECL2 207 W - Structure Structure
ECL2 208 N - Structure Structure
ECL2 209 C - Structure Structure
ECL2 210 L - Structure Structure
ECL2 211 A - Structure Structure
ECL2 212 E - Structure Structure
ECL2 213 R - Structure AF2
ECL2 214 A - Structure Structure
ECL2 215 A - Structure Structure
ECL2 216 C - Structure Structure
ECL2 217 S - Structure Structure
ECL2 218 V - Structure Structure
ECL2 219 V - Structure Structure
ECL2 220 R - Structure Structure
ECL2 221 P - Structure Structure
ECL2 222 L - Structure Structure
TM5 223 A 5.36x36 Structure Structure
TM5 224 R 5.37x37 Structure Structure
TM5 225 S 5.38x38 Structure Structure
TM5 226 H 5.39x39 Structure Structure
TM5 227 V 5.40x40 Structure Structure
TM5 228 A 5.41x41 Structure Structure
TM5 229 L 5.42x42 Structure Structure
TM5 230 L 5.43x43 Structure Structure
TM5 231 S 5.44x44 Structure Structure
TM5 232 A 5.45x45 Structure Structure
TM5 233 A 5.46x46 Structure Structure
TM5 234 F 5.47x47 Structure Structure
TM5 235 F 5.48x48 Structure Structure
TM5 236 M 5.49x49 Structure Structure
TM5 237 V 5.50x50 Structure Structure
TM5 238 F 5.51x51 Structure Structure
TM5 239 G 5.52x52 Structure Structure
TM5 240 I 5.53x53 Structure Structure
TM5 241 M 5.54x54 Structure Structure
TM5 242 L 5.55x55 Structure Structure
TM5 243 H 5.56x56 Structure Structure
TM5 244 L 5.57x57 Structure Structure
TM5 245 Y 5.58x58 Structure Structure
TM5 246 V 5.59x59 Structure Structure
TM5 247 R 5.60x60 Structure Structure
TM5 248 I 5.61x61 Structure Structure
TM5 249 C 5.62x62 Structure Structure
TM5 250 Q 5.63x63 Structure Structure
TM5 251 V 5.64x64 Structure Structure
TM5 252 V 5.65x65 Structure Structure
TM5 253 W 5.66x66 Structure Structure
TM5 254 R 5.67x67 Structure Structure
TM5 255 H 5.68x68 Structure Structure
TM5 256 A 5.69x69 Structure Structure
TM5 257 H 5.70x70 Structure Structure
TM5 258 Q 5.71x71 Structure Structure
TM5 259 I 5.72x72 Structure Structure
TM5 260 A 5.73x73 Structure Structure
ICL3 261 L - Structure Structure
ICL3 262 Q - Structure Structure
ICL3 263 Q - Structure Structure
ICL3 264 H - Structure Structure
ICL3 265 C - AF2 AF2
TM6 266 L 6.22x22 AF2 AF2
TM6 267 A 6.23x23 AF2 AF2
TM6 268 P 6.24x24 AF2 AF2
TM6 269 P 6.25x25 AF2 AF2
TM6 270 H 6.26x26 AF2 AF2
TM6 271 L 6.27x27 AF2 AF2
TM6 272 A 6.28x28 AF2 AF2
TM6 273 A 6.29x29 AF2 AF2
TM6 274 T 6.30x30 Structure Structure
TM6 275 R 6.31x31 Structure Structure
TM6 276 K 6.32x32 Structure Structure
TM6 277 G 6.33x33 Structure Structure
TM6 278 V 6.34x34 Structure Structure
TM6 279 G 6.35x35 Structure Structure
TM6 280 T 6.36x36 Structure Structure
TM6 281 L 6.37x37 Structure Structure
TM6 282 A 6.38x38 Structure Structure
TM6 283 V 6.39x39 Structure Structure
TM6 284 V 6.40x40 Structure Structure
TM6 285 L 6.41x41 Structure Structure
TM6 286 G 6.42x42 Structure Structure
TM6 287 T 6.43x43 Structure Structure
TM6 288 F 6.44x44 Structure Structure
TM6 289 G 6.45x45 Structure Structure
TM6 290 A 6.46x46 Structure Structure
TM6 291 S 6.47x47 Structure Structure
TM6 292 W 6.48x48 Structure Structure
TM6 293 L 6.49x49 Structure Structure
TM6 294 P 6.50x50 Structure Structure
TM6 295 F 6.51x51 Structure Structure
TM6 296 A 6.52x52 Structure Structure
TM6 297 I 6.53x53 Structure Structure
TM6 298 Y 6.54x54 Structure Structure
TM6 299 C 6.55x55 Structure Structure
TM6 300 V 6.56x56 Structure Structure
TM6 301 V 6.57x57 Structure Structure
TM6 302 G 6.58x58 Structure Structure
ECL3 303 S - Structure Structure
ECL3 304 H - Structure Structure
ECL3 305 E - Structure Structure
ECL3 306 D - Structure Structure
ECL3 307 P - Structure Structure
TM7 308 A 7.32x31 Structure Structure
TM7 309 V 7.33x32 Structure Structure
TM7 310 Y 7.34x33 Structure Structure
TM7 311 T 7.35x34 Structure Structure
TM7 312 Y 7.36x35 Structure Structure
TM7 313 A 7.37x36 Structure Structure
TM7 314 T 7.38x37 Structure Structure
TM7 315 L 7.39x38 Structure Structure
TM7 316 L 7.40x39 Structure Structure
TM7 317 P 7.41x40 Structure Structure
TM7 318 A 7.42x41 Structure Structure
TM7 319 T 7.43x42 Structure Structure
TM7 320 Y 7.44x43 Structure Structure
TM7 321 N 7.45x45 Structure Structure
TM7 322 S 7.46x46 Structure Structure
TM7 323 M 7.47x47 Structure Structure
TM7 324 I 7.48x48 Structure Structure
TM7 325 N 7.49x49 Structure Structure
TM7 326 P 7.50x50 Structure Structure
TM7 327 I 7.51x51 Structure Structure
TM7 328 I 7.52x52 Structure Structure
TM7 329 Y 7.53x53 Structure Structure
TM7 330 A 7.54x54 Structure Structure
TM7 331 F 7.55x55 Structure Structure
TM7 332 R 7.56x56 Structure Structure
H8 333 N 8.47x47 Structure Structure
H8 334 Q 8.48x48 Structure Structure
H8 335 E 8.49x49 Structure Structure
H8 336 I 8.50x50 Structure Structure
H8 337 Q 8.51x51 Structure Structure
H8 338 R 8.52x52 Structure Structure
H8 339 A 8.53x53 Structure Structure
H8 340 L 8.54x54 Structure Structure
H8 341 W 8.55x55 Structure Structure
H8 342 L 8.56x56 Structure Structure
H8 343 L 8.57x57 Structure Structure
H8 344 L 8.58x58 Structure Structure
H8 345 C 8.59x59 AF2 AF2
C-term 346 G - AF2 AF2
C-term 347 C - AF2 AF2
C-term 348 F - AF2 AF2
C-term 349 Q - AF2 AF2
C-term 350 S - AF2 AF2
C-term 351 K - AF2 AF2
C-term 352 V - AF2 AF2
C-term 353 P - AF2 AF2
C-term 354 F - AF2 AF2
C-term 355 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Y 177 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 177 34x54 G.HN Q 35 G.HN.52
Aromatic TM5 H 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL3 Q 262 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 262 - G.H4 L 346 G.H4.16
Polar ICL3 Q 262 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 262 - G.S6 C 359 G.S6.01
Van-der-waals C-term R 355 - G.h2s4 N 239 G.h2s4.02
Polar ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Polar TM6 T 280 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 280 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 280 6x36 G.H5 E 392 G.H5.24
Polar TM3 S 169 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 169 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 H 387 G.H5.19
Polar TM6 K 276 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 276 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 276 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 173 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 173 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 L 266 6x22 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM6 L 266 6x22 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 256 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Polar H8 N 333 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 170 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 170 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Polar H8 E 335 8x49 G.H5 Q 390 G.H5.22
Ionic ICL3 H 264 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 174 34x51 G.S3 F 219 G.S3.03
Polar TM5 R 254 5x67 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 259 5x72 G.H5 L 394 G.H5.26
Hydrophobic ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 H 255 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 259 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL3 L 261 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 L 261 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 Q 262 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 262 - G.h4s6 T 350 G.h4s6.03
Polar TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 248 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 255 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 Y 176 34x53 G.H5 H 387 G.H5.19
Polar TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 266 6x22 G.H4 D 343 G.H4.13
Van-der-waals TM6 L 266 6x22 G.H4 D 343 G.H4.13
Hydrophobic ICL2 T 175 34x52 G.S3 V 217 G.S3.01
Polar TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 266 6x22 G.H4 L 346 G.H4.16
Van-der-waals TM6 L 266 6x22 G.H4 L 346 G.H4.16
Polar ICL2 Y 177 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL3 Q 263 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 T 280 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 252 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 252 5x65 G.H5 L 388 G.H5.20
Ionic TM5 R 254 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM6 G 277 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 277 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 252 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 255 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM7 R 332 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 332 7x56 G.H5 E 392 G.H5.24
Polar H8 Q 334 8x48 G.h4s6 R 356 G.h4s6.12
Polar TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 173 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 266 6x22 G.H4 R 347 G.H4.17
Hydrophobic ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL3 C 265 - G.hgh4 P 321 G.hgh4.11