glucagon receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6WHC

RESOLUTION

3.4 Å

REFERENCE

10.1074/JBC.RA120.013793

PUBLICATION DATE

May 27, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

80 interactions (Click to see)

LIGANDS

Dual-agonist peptide P15 - Agonist

PHYSIOLOGICAL LIGANDS

glucagon



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Polar TM3 L 252 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 252 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 252 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM7 Y 400 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 253 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 253 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 256 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 328 5x60 G.H5 Q 384 G.H5.16
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Polar TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 332 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 332 5x64 G.H5 R 385 G.H5.17
Polar TM6 T 351 6x42 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 351 6x42 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 351 6x42 G.H5 L 393 G.H5.25
Polar ICL2 A 256 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 256 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Polar TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 R 336 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 R 336 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 R 336 - G.S6 C 359 G.S6.01
Hydrophobic ICL2 A 256 - G.S3 V 217 G.S3.01
Polar ICL2 T 257 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 257 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 252 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 336 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 A 256 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 258 - G.H5 M 386 G.H5.18
Polar H8 K 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 405 8x48 G.H5 E 392 G.H5.24
Polar ICL3 A 335 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 M 338 - G.h4s6 G 353 G.h4s6.09
Hydrophobic TM5 L 329 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 338 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 M 338 - G.h4s6 T 350 G.h4s6.03
Hydrophobic H8 N 404 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Polar TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 336 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 336 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 A 256 - G.H5 I 383 G.H5.15
Polar ICL2 T 257 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 257 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 T 257 - G.S1 H 41 G.S1.02
Polar ICL2 E 260 - G.HN K 34 G.HN.51
Polar ICL2 T 257 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 T 257 - G.hns1 A 39 G.hns1.03
Aromatic ICL3 R 336 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 R 336 - G.S6 Y 360 G.S6.02
Hydrophobic TM6 I 355 6x46 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 355 6x46 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 329 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 329 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 329 5x61 G.H5 L 388 G.H5.20
Polar ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 258 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 328 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM5 K 332 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 260 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 E 260 - G.hns1 A 39 G.hns1.03
Polar ICL2 P 259 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 259 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 259 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 260 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 260 - G.HN Q 35 G.HN.52
Polar ICL2 E 260 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 253 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 258 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 L 258 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 257 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 325 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 248 3x53 G.H5 Y 391 G.H5.23