NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VBA

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41586-026-10228-W

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

46 interactions (Click to see)

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 L 105 2x43 G.H5 C 351 G.H5.23
Hydrophobic TM6 H 300 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 300 6x32 G.H5 F 354 G.H5.26
Polar ICL4 L 366 - G.H5 C 351 G.H5.23
Hydrophobic ICL4 L 366 - G.H5 C 351 G.H5.23
Van-der-waals ICL4 L 366 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 177 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM6 G 301 6x33 G.H5 G 352 G.H5.24
Van-der-waals TM6 G 301 6x33 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL4 L 366 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 L 366 - G.H5 F 354 G.H5.26
Hydrophobic ICL1 L 94 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 L 94 - G.hns1 A 31 G.hns1.02
Polar ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL1 Q 95 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 174 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 F 174 34x51 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 297 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM7 N 365 7x54 G.H5 F 354 G.H5.26
Van-der-waals TM7 N 365 7x54 G.H5 F 354 G.H5.26
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Polar ICL2 L 179 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 101 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 Q 98 2x36 G.H5 K 349 G.H5.21
Van-der-waals TM2 Q 98 2x36 G.H5 K 349 G.H5.21
Polar ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 177 34x54 G.S1 V 34 G.S1.02
Polar TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 S 181 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 V 295 6x27 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM7 N 365 7x54 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 101 2x39 G.H5 C 351 G.H5.23
Aromatic ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 V 304 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 304 6x36 G.H5 F 354 G.H5.26
Polar TM7 Y 364 7x53 G.H5 C 351 G.H5.23
Hydrophobic TM7 Y 364 7x53 G.H5 C 351 G.H5.23
Van-der-waals TM7 Y 364 7x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Polar TM4 R 182 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 R 182 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 R 182 4x39 G.HN E 28 G.HN.52
Polar TM6 G 301 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 G 301 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 L 363 7x52 G.H5 F 354 G.H5.26
Van-der-waals TM7 L 363 7x52 G.H5 F 354 G.H5.26
Hydrophobic ICL4 N 370 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 F 174 34x51 G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Polar TM4 S 183 4x40 G.HN E 28 G.HN.52