TAAR13C - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Danio rerio

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9M3Q

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

March 11, 2026

3D VIEW

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LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

SPERMIDINE - Agonist chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 137 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 232 G.H5.12
Hydrophobic ICL2 L 138 - G.S3 F 81 G.S3.03
Polar TM5 S 231 5x71 G.H5 R 237 G.H5.17
Hydrophobic TM5 I 221 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 221 5x61 G.H5 L 245 G.H5.25
Ionic TM6 K 253 6x32 G.H5 E 244 G.H5.24
Polar TM6 K 253 6x32 G.H5 E 244 G.H5.24
Hydrophobic TM6 K 253 6x32 G.H5 E 244 G.H5.24
Van-der-waals TM6 K 253 6x32 G.H5 E 244 G.H5.24
Hydrophobic ICL2 L 138 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 L 138 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 228 G.H5.08
Hydrophobic TM6 T 257 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 T 257 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM5 H 228 5x68 G.H5 L 240 G.H5.20
Hydrophobic TM7 F 312 7x56 G.H5 E 244 G.H5.24
Hydrophobic TM5 I 232 5x72 G.h4s6 Y 210 G.h4s6.20
Polar TM3 A 133 3x53 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 239 G.H5.19
Hydrophobic ICL3 N 236 - G.h4s6 T 202 G.h4s6.03
Van-der-waals ICL3 N 236 - G.h4s6 T 202 G.h4s6.03
Hydrophobic TM3 V 134 3x54 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 137 - G.H5 H 239 G.H5.19
Hydrophobic H8 W 315 8x49 G.H5 Q 242 G.H5.22
Van-der-waals H8 W 315 8x49 G.H5 Q 242 G.H5.22
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 41 G.S1.02
Polar TM6 K 253 6x32 G.H5 L 246 G.H5.26
Hydrophobic TM6 K 253 6x32 G.H5 L 246 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 L 246 G.H5.26
Hydrophobic ICL2 P 137 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 P 137 - G.H2 I 235 G.H2.08
Polar TM5 H 228 5x68 G.H5 Q 236 G.H5.16
Hydrophobic TM5 H 228 5x68 G.H5 Q 236 G.H5.16
Van-der-waals TM5 H 228 5x68 G.H5 Q 236 G.H5.16
Polar ICL2 T 142 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 142 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 V 134 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM6 A 254 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 A 254 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM5 V 224 5x64 G.H5 Q 236 G.H5.16
Polar TM3 V 134 3x54 G.H5 Q 236 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 L 138 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 L 138 - G.H2 I 235 G.H2.08
Hydrophobic H8 W 315 8x49 G.H5 Y 243 G.H5.23
Hydrophobic TM7 Y 313 7x57 G.H5 E 244 G.H5.24
Hydrophobic ICL2 L 138 - G.H5 C 231 G.H5.11
Van-der-waals ICL2 L 138 - G.H5 C 231 G.H5.11
Polar ICL2 Q 139 - G.s2s3 D 77 G.s2s3.01
Hydrophobic TM5 V 224 5x64 G.H5 L 240 G.H5.20
Hydrophobic TM7 Y 313 7x57 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 258 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 258 6x37 G.H5 L 245 G.H5.25
Hydrophobic TM5 A 225 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 137 - G.H5 Q 236 G.H5.16
Van-der-waals ICL2 P 137 - G.H5 Q 236 G.H5.16
Hydrophobic ICL2 P 141 - G.hns1 A 38 G.hns1.02
Van-der-waals ICL2 P 141 - G.hns1 A 38 G.hns1.02
Hydrophobic ICL2 L 138 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 L 138 - G.H5 R 232 G.H5.12
Van-der-waals TM5 I 232 5x72 G.H5 R 237 G.H5.17
Hydrophobic TM5 I 232 5x72 G.H5 L 246 G.H5.26
Van-der-waals TM5 I 232 5x72 G.H5 L 246 G.H5.26
Van-der-waals ICL2 P 141 - G.hns1 A 37 G.hns1.01
Polar TM6 T 257 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM6 T 257 6x36 G.H5 E 244 G.H5.24
Van-der-waals TM6 T 257 6x36 G.H5 E 244 G.H5.24
Hydrophobic ICL2 Q 139 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 Q 139 - G.S3 V 79 G.S3.01
Hydrophobic TM5 H 228 5x68 G.H5 D 233 G.H5.13
Van-der-waals TM5 H 228 5x68 G.H5 D 233 G.H5.13
Aromatic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 140 - G.H5 H 239 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 Y 243 G.H5.23
Polar TM5 H 228 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 H 228 5x68 G.H5 R 237 G.H5.17
Van-der-waals TM5 H 228 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 H 228 5x68 G.H5 L 246 G.H5.26
Van-der-waals TM5 H 228 5x68 G.H5 L 246 G.H5.26
Polar ICL2 P 141 - G.hns1 A 39 G.hns1.03