κ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9W49

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

U50488 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), β-neoendorphin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), big dynorphin (Human), β-endorphin (Mouse), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL3 R 257 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 257 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 257 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 258 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 258 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 272 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 256 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 253 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 253 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 272 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 156 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 156 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 E 335 8x48 G.H5 L 353 G.H5.25
Ionic TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 159 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 159 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 E 335 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 335 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 N 336 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 336 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 N 268 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 164 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 R 252 5x64 G.H5 I 344 G.H5.16
Polar TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 159 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 258 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 258 - G.H5 K 345 G.H5.17
Hydrophobic TM6 I 272 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 272 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 167 34x54 G.H5 I 343 G.H5.15
Ionic ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 160 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 160 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 163 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 163 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 167 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 164 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 164 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 167 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 167 34x54 G.S3 L 194 G.S3.01
Polar ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 94 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 94 2x39 G.H5 C 351 G.H5.23
Polar TM2 T 92 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 92 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 92 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 M 249 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 249 5x61 G.H5 L 353 G.H5.25
Ionic ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 164 34x51 G.S3 L 194 G.S3.01
Polar TM6 R 271 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 271 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 271 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 D 334 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 334 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 258 - G.H5 F 354 G.H5.26
Polar ICL3 R 257 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 257 - G.H5 D 341 G.H5.13
Polar ICL3 R 257 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 257 - G.S6 I 319 G.S6.01
Hydrophobic ICL2 P 163 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 163 34x50 G.H5 I 344 G.H5.16
Polar H8 N 336 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 D 168 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 R 156 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 156 3x50 G.H5 C 351 G.H5.23
Polar H8 E 335 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 335 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 335 8x48 G.H5 G 352 G.H5.24
Polar TM2 T 94 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 94 2x39 G.H5 D 350 G.H5.22