GABA-B-R2 - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Drosophila melanogaster

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9JR0

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Oct. 22, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

GABA - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 K 479 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 557 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 V 557 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 552 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 552 - G.H5 I 343 G.H5.15
Polar TM3 I 547 3x61 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 547 3x61 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 551 - G.S3 L 194 G.S3.01
Hydrophobic ICL1 R 476 - G.H5 F 354 G.H5.26
Van-der-waals ICL1 R 476 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 547 3x61 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 547 3x61 G.H5 C 351 G.H5.23
Ionic TM3 D 550 3x64 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 652 6x35 G.H5 L 353 G.H5.25
Polar ICL2 V 557 - G.H5 D 350 G.H5.22
Hydrophobic TM2 S 482 2x31 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 482 2x31 G.H5 L 353 G.H5.25
Polar ICL1 M 480 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 M 480 - G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 479 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 553 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 543 3x57 G.H5 C 351 G.H5.23
Polar ICL2 L 553 - G.H5 N 346 G.H5.18
Hydrophobic ICL2 L 553 - G.H5 N 346 G.H5.18
Van-der-waals ICL2 L 553 - G.H5 N 346 G.H5.18
Polar ICL2 K 552 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 552 - G.H5 N 347 G.H5.19
Hydrophobic TM3 R 543 3x57 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 543 3x57 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 547 3x61 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 547 3x61 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 553 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 553 - G.h2s4 T 219 G.h2s4.05
Ionic TM4 K 559 4x18 G.H5 D 350 G.H5.22
Polar TM4 K 559 4x18 G.H5 D 350 G.H5.22
Van-der-waals TM4 K 559 4x18 G.H5 D 350 G.H5.22
Hydrophobic TM3 F 548 3x62 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 551 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 K 552 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 551 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 557 - G.H5 N 347 G.H5.19
Hydrophobic ICL1 M 480 - G.H5 L 348 G.H5.20
Hydrophobic TM3 I 547 3x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 652 6x35 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 551 - G.H5 T 340 G.H5.12
Hydrophobic C-term A 727 - G.S6 Y 320 G.S6.02
Van-der-waals C-term A 727 - G.S6 Y 320 G.S6.02
Ionic ICL2 K 552 - G.HN E 28 G.HN.52
Polar ICL2 K 552 - G.HN E 28 G.HN.52