Refined structure (8K2X) of Gi1 - CXCR3

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 216 from structure (61.0%), 138 from model (39.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 Structure Structure
G.hfs2 180 K G.hfs2.04 Structure Structure
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 AF2 AF2
G.s4h3 231 D G.s4h3.05 AF2 AF2
G.s4h3 232 L G.s4h3.06 AF2 AF2
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 290 from structure (83.8%), 56 from model (16.2%)
Residue sidechains - 290 from structure (83.8%), 56 from model (16.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 V - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 D - AF2 AF2
N-term 8 H - AF2 AF2
N-term 9 Q - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 D - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 E - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 F - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 Y - AF2 AF2
N-term 28 D - AF2 AF2
N-term 29 Y - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 E - AF2 AF2
N-term 34 S - AF2 AF2
N-term 35 D - AF2 AF2
N-term 36 S - AF2 AF2
N-term 37 C - AF2 AF2
N-term 38 C - AF2 AF2
N-term 39 T - AF2 AF2
N-term 40 S - AF2 AF2
N-term 41 P - AF2 AF2
N-term 42 P - AF2 AF2
N-term 43 C - AF2 AF2
N-term 44 P - AF2 AF2
TM1 45 Q 1.24x24 AF2 AF2
TM1 46 D 1.25x25 AF2 AF2
TM1 47 F 1.26x26 Structure Structure
TM1 48 S 1.27x27 Structure Structure
TM1 49 L 1.28x28 Structure Structure
TM1 50 N 1.29x29 Structure Structure
TM1 51 F 1.30x30 Structure Structure
TM1 52 D 1.31x31 Structure Structure
TM1 53 R 1.32x32 Structure Structure
TM1 54 A 1.33x33 Structure Structure
TM1 55 F 1.34x34 Structure Structure
TM1 56 L 1.35x35 Structure Structure
TM1 57 P 1.36x36 Structure Structure
TM1 58 A 1.37x37 Structure Structure
TM1 59 L 1.38x38 Structure Structure
TM1 60 Y 1.39x39 Structure Structure
TM1 61 S 1.40x40 Structure Structure
TM1 62 L 1.41x41 Structure Structure
TM1 63 L 1.42x42 Structure Structure
TM1 64 F 1.43x43 Structure Structure
TM1 65 L 1.44x44 Structure Structure
TM1 66 L 1.45x45 Structure Structure
TM1 67 G 1.46x46 Structure Structure
TM1 68 L 1.47x47 Structure Structure
TM1 69 L 1.48x48 Structure Structure
TM1 70 G 1.49x49 Structure Structure
TM1 71 N 1.50x50 Structure Structure
TM1 72 G 1.51x51 Structure Structure
TM1 73 A 1.52x52 Structure Structure
TM1 74 V 1.53x53 Structure Structure
TM1 75 A 1.54x54 Structure Structure
TM1 76 A 1.55x55 Structure Structure
TM1 77 V 1.56x56 Structure Structure
TM1 78 L 1.57x57 Structure Structure
TM1 79 L 1.58x58 Structure Structure
TM1 80 S 1.59x59 Structure Structure
TM1 81 R 1.60x60 Structure Structure
ICL1 82 R 12.48x48 Structure Structure
ICL1 83 T 12.49x49 Structure Structure
ICL1 84 A 12.50x50 Structure Structure
ICL1 85 L 12.51x51 Structure Structure
TM2 86 S 2.37x37 Structure Structure
TM2 87 S 2.38x38 Structure Structure
TM2 88 T 2.39x39 Structure Structure
TM2 89 D 2.40x40 Structure Structure
TM2 90 T 2.41x41 Structure Structure
TM2 91 F 2.42x42 Structure Structure
TM2 92 L 2.43x43 Structure Structure
TM2 93 L 2.44x44 Structure Structure
TM2 94 H 2.45x45 Structure Structure
TM2 95 L 2.46x46 Structure Structure
TM2 96 A 2.47x47 Structure Structure
TM2 97 V 2.48x48 Structure Structure
TM2 98 A 2.49x49 Structure Structure
TM2 99 D 2.50x50 Structure Structure
TM2 100 T 2.51x51 Structure Structure
TM2 101 L 2.52x52 Structure Structure
TM2 102 L 2.53x53 Structure Structure
TM2 103 V 2.54x54 Structure Structure
TM2 104 L 2.55x55 Structure Structure
TM2 105 T 2.56x56 Structure Structure
TM2 106 L 2.57x57 Structure Structure
TM2 107 P 2.58x58 Structure Structure
TM2 108 L 2.59x59 Structure Structure
TM2 109 W 2.60x60 Structure Structure
TM2 110 A 2.61x61 Structure Structure
TM2 111 V 2.62x62 Structure Structure
TM2 112 D 2.63x63 Structure Structure
TM2 113 A 2.64x64 Structure Structure
TM2 114 A 2.65x65 Structure Structure
TM2 115 V 2.66x66 Structure Structure
ECL1 116 Q 23.49x49 Structure Structure
ECL1 117 W 23.50x50 Structure Structure
ECL1 118 V 23.51x51 Structure Structure
ECL1 119 F 23.52x52 Structure Structure
TM3 120 G 3.21x21 Structure Structure
TM3 121 S 3.22x22 Structure Structure
TM3 122 G 3.23x23 Structure Structure
TM3 123 L 3.24x24 Structure Structure
TM3 124 C 3.25x25 Structure Structure
TM3 125 K 3.26x26 Structure Structure
TM3 126 V 3.27x27 Structure Structure
TM3 127 A 3.28x28 Structure Structure
TM3 128 G 3.29x29 Structure Structure
TM3 129 A 3.30x30 Structure Structure
TM3 130 L 3.31x31 Structure Structure
TM3 131 F 3.32x32 Structure Structure
TM3 132 N 3.33x33 Structure Structure
TM3 133 I 3.34x34 Structure Structure
TM3 134 N 3.35x35 Structure Structure
TM3 135 F 3.36x36 Structure Structure
TM3 136 Y 3.37x37 Structure Structure
TM3 137 A 3.38x38 Structure Structure
TM3 138 G 3.39x39 Structure Structure
TM3 139 A 3.40x40 Structure Structure
TM3 140 L 3.41x41 Structure Structure
TM3 141 L 3.42x42 Structure Structure
TM3 142 L 3.43x43 Structure Structure
TM3 143 A 3.44x44 Structure Structure
TM3 144 C 3.45x45 Structure Structure
TM3 145 I 3.46x46 Structure Structure
TM3 146 S 3.47x47 Structure Structure
TM3 147 F 3.48x48 Structure Structure
TM3 148 D 3.49x49 Structure Structure
TM3 149 R 3.50x50 Structure Structure
TM3 150 Y 3.51x51 Structure Structure
TM3 151 L 3.52x52 Structure Structure
TM3 152 N 3.53x53 Structure Structure
TM3 153 I 3.54x54 Structure Structure
TM3 154 V 3.55x55 Structure Structure
TM3 155 H 3.56x56 Structure Structure
ICL2 156 A 34.50x50 Structure Structure
ICL2 157 T 34.51x51 Structure Structure
ICL2 158 Q 34.52x52 Structure Structure
ICL2 159 L 34.53x53 Structure Structure
ICL2 160 Y 34.54x54 Structure Structure
ICL2 161 R 34.55x55 Structure Structure
ICL2 162 R 34.56x56 Structure Structure
ICL2 163 G 34.57x57 Structure Structure
ICL2 164 P - Structure Structure
ICL2 165 P - Structure Structure
TM4 166 A 4.40x40 Structure Structure
TM4 167 R 4.41x41 Structure Structure
TM4 168 V 4.42x42 Structure Structure
TM4 169 T 4.43x43 Structure Structure
TM4 170 L 4.44x44 Structure Structure
TM4 171 T 4.45x45 Structure Structure
TM4 172 C 4.46x46 Structure Structure
TM4 173 L 4.47x47 Structure Structure
TM4 174 A 4.48x48 Structure Structure
TM4 175 V 4.49x49 Structure Structure
TM4 176 W 4.50x50 Structure Structure
TM4 177 G 4.51x51 Structure Structure
TM4 178 L 4.52x52 Structure Structure
TM4 179 C 4.53x53 Structure Structure
TM4 180 L 4.54x54 Structure Structure
TM4 181 L 4.55x55 Structure Structure
TM4 182 F 4.56x56 Structure Structure
TM4 183 A 4.57x57 Structure Structure
TM4 184 L 4.58x59 Structure Structure
TM4 185 P 4.59x60 Structure Structure
TM4 186 D 4.60x61 Structure Structure
TM4 187 F 4.61x62 Structure Structure
TM4 188 I 4.62x63 Structure Structure
TM4 189 F 4.63x64 Structure Structure
TM4 190 L 4.64x65 Structure Structure
ECL2 191 S - Structure Structure
ECL2 192 A - Structure Structure
ECL2 193 H - Structure Structure
ECL2 194 H - Structure Structure
ECL2 195 D - Structure Structure
ECL2 196 E - Structure Structure
ECL2 197 R - Structure Structure
ECL2 198 L - Structure Structure
ECL2 199 N - Structure Structure
ECL2 200 A - Structure Structure
ECL2 201 T - Structure Structure
ECL2 202 H - Structure Structure
ECL2 203 C 45.50x50 Structure Structure
ECL2 204 Q 45.51x51 Structure Structure
ECL2 205 Y 45.52x52 Structure Structure
ECL2 206 N - Structure Structure
ECL2 207 F - Structure Structure
TM5 208 P 5.31x32 Structure Structure
TM5 209 Q 5.32x33 Structure Structure
TM5 210 V 5.33x34 Structure Structure
TM5 211 G 5.34x35 Structure Structure
TM5 212 R 5.35x36 Structure Structure
TM5 213 T 5.36x37 Structure Structure
TM5 214 A 5.37x38 Structure Structure
TM5 215 L 5.38x39 Structure Structure
TM5 216 R 5.39x40 Structure Structure
TM5 217 V 5.40x41 Structure Structure
TM5 218 L 5.41x42 Structure Structure
TM5 219 Q 5.42x43 Structure Structure
TM5 220 L 5.43x44 Structure Structure
TM5 221 V 5.44x45 Structure Structure
TM5 222 A 5.45x46 Structure Structure
TM5 223 G 5.46x461 Structure Structure
TM5 224 F 5.47x47 Structure Structure
TM5 225 L 5.48x48 Structure Structure
TM5 226 L 5.49x49 Structure Structure
TM5 227 P 5.50x50 Structure Structure
TM5 228 L 5.51x51 Structure Structure
TM5 229 L 5.52x52 Structure Structure
TM5 230 V 5.53x53 Structure Structure
TM5 231 M 5.54x54 Structure Structure
TM5 232 A 5.55x55 Structure Structure
TM5 233 Y 5.56x56 Structure Structure
TM5 234 C 5.57x57 Structure Structure
TM5 235 Y 5.58x58 Structure Structure
TM5 236 A 5.59x59 Structure Structure
TM5 237 H 5.60x60 Structure Structure
TM5 238 I 5.61x61 Structure Structure
TM5 239 L 5.62x62 Structure Structure
TM5 240 A 5.63x63 Structure Structure
TM5 241 V 5.64x64 Structure Structure
TM5 242 L 5.65x65 Structure Structure
TM5 243 L 5.66x66 Structure Structure
TM5 244 V 5.67x67 Structure Structure
TM5 245 S 5.68x68 Structure Structure
ICL3 246 R - Structure Structure
ICL3 247 G - Structure Structure
ICL3 248 Q - Structure Structure
TM6 249 R 6.29x29 Structure Structure
TM6 250 R 6.30x30 Structure Structure
TM6 251 L 6.31x31 Structure Structure
TM6 252 R 6.32x32 Structure Structure
TM6 253 A 6.33x33 Structure Structure
TM6 254 M 6.34x34 Structure Structure
TM6 255 R 6.35x35 Structure Structure
TM6 256 L 6.36x36 Structure Structure
TM6 257 V 6.37x37 Structure Structure
TM6 258 V 6.38x38 Structure Structure
TM6 259 V 6.39x39 Structure Structure
TM6 260 V 6.40x40 Structure Structure
TM6 261 V 6.41x41 Structure Structure
TM6 262 V 6.42x42 Structure Structure
TM6 263 A 6.43x43 Structure Structure
TM6 264 F 6.44x44 Structure Structure
TM6 265 A 6.45x45 Structure Structure
TM6 266 L 6.46x46 Structure Structure
TM6 267 C 6.47x47 Structure Structure
TM6 268 W 6.48x48 Structure Structure
TM6 269 T 6.49x49 Structure Structure
TM6 270 P 6.50x50 Structure Structure
TM6 271 Y 6.51x51 Structure Structure
TM6 272 H 6.52x52 Structure Structure
TM6 273 L 6.53x53 Structure Structure
TM6 274 V 6.54x54 Structure Structure
TM6 275 V 6.55x55 Structure Structure
TM6 276 L 6.56x56 Structure Structure
TM6 277 V 6.57x57 Structure Structure
TM6 278 D 6.58x58 Structure Structure
TM6 279 I 6.59x59 Structure Structure
TM6 280 L 6.60x60 Structure Structure
TM6 281 M 6.61x61 Structure Structure
TM6 282 D 6.62x62 Structure Structure
TM6 283 L 6.63x63 Structure Structure
TM6 284 G 6.64x64 Structure Structure
ECL3 285 A - Structure Structure
ECL3 286 L - Structure Structure
ECL3 287 A - Structure Structure
ECL3 288 R - Structure Structure
TM7 289 N 7.24x23 Structure Structure
TM7 290 C 7.25x24 Structure Structure
TM7 291 G 7.26x25 Structure Structure
TM7 292 R 7.27x26 Structure Structure
TM7 293 E 7.28x27 Structure Structure
TM7 294 S 7.29x28 Structure Structure
TM7 295 R 7.30x29 Structure Structure
TM7 296 V 7.31x30 Structure Structure
TM7 297 D 7.32x31 Structure Structure
TM7 298 V 7.33x32 Structure Structure
TM7 299 A 7.34x33 Structure Structure
TM7 300 K 7.35x34 Structure Structure
TM7 301 S 7.36x35 Structure Structure
TM7 302 V 7.37x36 Structure Structure
TM7 303 T 7.38x37 Structure Structure
TM7 304 S 7.39x38 Structure Structure
TM7 305 G 7.40x39 Structure Structure
TM7 306 L 7.41x40 Structure Structure
TM7 307 G 7.42x41 Structure Structure
TM7 308 Y 7.43x42 Structure Structure
TM7 309 M 7.44x43 Structure Structure
TM7 310 H 7.45x45 Structure Structure
TM7 311 C 7.46x46 Structure Structure
TM7 312 C 7.47x47 Structure Structure
TM7 313 L 7.48x48 Structure Structure
TM7 314 N 7.49x49 Structure Structure
TM7 315 P 7.50x50 Structure Structure
TM7 316 L 7.51x51 Structure Structure
TM7 317 L 7.52x52 Structure Structure
TM7 318 Y 7.53x53 Structure Structure
TM7 319 A 7.54x54 Structure Structure
TM7 320 F 7.55x55 Structure Structure
TM7 321 V 7.56x56 Structure Structure
H8 322 G 8.47x47 Structure Structure
H8 323 V 8.48x48 Structure Structure
H8 324 K 8.49x49 Structure Structure
H8 325 F 8.50x50 Structure Structure
H8 326 R 8.51x51 Structure Structure
H8 327 E 8.52x52 Structure Structure
H8 328 R 8.53x53 Structure Structure
H8 329 M 8.54x54 Structure Structure
H8 330 W 8.55x55 Structure Structure
H8 331 M 8.56x56 Structure Structure
H8 332 L 8.57x57 Structure Structure
H8 333 L 8.58x58 Structure Structure
H8 334 L 8.59x59 Structure Structure
H8 335 R 8.60x60 Structure Structure
H8 336 L 8.61x61 Structure Structure
C-term 337 G - AF2 AF2
C-term 338 C - AF2 AF2
C-term 339 P - AF2 AF2
C-term 340 N - AF2 AF2
C-term 341 Q - AF2 AF2
C-term 342 R - AF2 AF2
C-term 343 G - AF2 AF2
C-term 344 L - AF2 AF2
C-term 345 Q - AF2 AF2
C-term 346 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 153 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 165 - G.HN E 28 G.HN.52
Van-der-waals ICL2 P 165 - G.HN E 28 G.HN.52
Polar ICL2 G 163 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 163 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 253 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 153 3x54 G.H5 C 351 G.H5.23
Polar H8 G 322 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 322 8x47 G.H5 G 352 G.H5.24
Polar TM6 R 249 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 242 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Y 160 34x54 G.S1 V 34 G.S1.02
Ionic H8 K 324 8x49 G.H5 D 350 G.H5.22
Polar H8 K 324 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 G 247 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 R 161 34x55 G.S3 L 194 G.S3.01
Polar TM5 S 245 5x68 G.H5 D 341 G.H5.13
Polar TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 88 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 156 34x50 G.H5 I 344 G.H5.16
Polar ICL2 T 157 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Ionic ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 V 257 6x37 G.H5 L 353 G.H5.25
Ionic TM6 R 249 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 K 324 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 T 157 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 Y 160 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Y 160 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Y 160 34x54 G.S3 L 194 G.S3.01
Polar ICL2 Y 160 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic H8 V 323 8x48 G.H5 K 349 G.H5.21
Polar ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 249 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 249 6x29 G.H5 K 345 G.H5.17
Polar ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM3 I 153 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 153 3x54 G.H5 L 348 G.H5.20
Polar H8 V 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 V 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 252 6x32 G.H5 F 354 G.H5.26
Polar TM3 N 152 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 N 152 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 N 152 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 156 34x50 G.H5 I 343 G.H5.15
Polar ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 R 246 - G.H5 K 345 G.H5.17
Hydrophobic TM3 R 149 3x50 G.H5 L 353 G.H5.25
Polar TM2 S 86 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 256 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 249 6x29 G.H5 L 348 G.H5.20
Polar TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 C 351 G.H5.23
Aromatic TM6 R 249 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 249 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 249 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 157 34x51 G.S3 L 194 G.S3.01