NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9P85

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-026-10120-7

PUBLICATION DATE

March 25, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

NTS8–13 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 178 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 178 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 173 34x50 G.H5 L 348 G.H5.20
Polar ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 F 174 34x51 G.H5 K 345 G.H5.17
Hydrophobic ICL2 F 174 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 F 174 34x51 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 173 34x50 G.H5 K 345 G.H5.17
Polar ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 177 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM5 M 266 5x68 G.H5 K 349 G.H5.21
Hydrophobic ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Polar TM4 S 181 4x38 G.hns1 R 32 G.hns1.03