SST1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9IK9

RESOLUTION

3.4 Å

REFERENCE

10.1016/J.APSB.2025.03.043

PUBLICATION DATE

April 30, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

LANREOTIDE - Agonist chembl_ligand pubchem pubchem drugbank

PHYSIOLOGICAL LIGANDS

cortistatin-14 (Mouse), SRIF-14 (Human), SRIF-28 (Human), CST-17 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 256 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 256 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 256 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 M 250 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 250 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM3 R 155 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 269 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 F 354 G.H5.26
Polar ICL2 I 163 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 S 327 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 166 - G.HN E 28 G.HN.52
Polar TM6 K 268 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 268 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 268 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 249 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 249 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 G 258 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 G 258 - G.H5 F 334 G.H5.06
Hydrophobic TM5 A 257 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 A 257 5x72 G.H5 F 334 G.H5.06
Polar TM3 R 155 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 C 351 G.H5.23
Polar ICL3 G 258 - G.S6 T 321 G.S6.03
Hydrophobic TM6 I 269 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 246 5x61 G.H5 L 353 G.H5.25
Polar ICL3 W 259 - G.S6 Y 320 G.S6.02
Aromatic ICL3 W 259 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 W 259 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 W 259 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 A 257 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 A 257 5x72 G.S6 Y 320 G.S6.02
Van-der-waals ICL2 P 162 - G.H5 N 347 G.H5.19
Hydrophobic TM3 V 159 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 159 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 159 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 159 3x54 G.H5 N 347 G.H5.19
Ionic H8 D 328 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 D 328 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 A 158 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 273 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 273 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 253 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 V 253 5x68 G.H5 T 340 G.H5.12
Polar TM3 A 158 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 253 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 253 5x68 G.H5 I 344 G.H5.16