Refined structure (7XV3) of Gs - GPR174

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 234 from structure (59.4%), 160 from model (40.6%)
Residue sidechains - 215 from structure (54.6%), 179 from model (45.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure AF2
G.H1 64 H G.H1.12 Structure Structure
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure AF2
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 286 from structure (89.9%), 32 from model (10.1%)
Residue sidechains - 286 from structure (89.9%), 32 from model (10.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 Y - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 C - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 R - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 D - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 D - AF2 AF2
N-term 14 N - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 D - AF2 AF2
TM1 17 F 1.30x30 AF2 AF2
TM1 18 R 1.31x31 Structure Structure
TM1 19 Y 1.32x32 Structure Structure
TM1 20 F 1.33x33 Structure Structure
TM1 21 I 1.34x34 Structure Structure
TM1 22 Y 1.35x35 Structure Structure
TM1 23 A 1.36x36 Structure Structure
TM1 24 V 1.37x37 Structure Structure
TM1 25 T 1.38x38 Structure Structure
TM1 26 Y 1.39x39 Structure Structure
TM1 27 T 1.40x40 Structure Structure
TM1 28 V 1.41x41 Structure Structure
TM1 29 I 1.42x42 Structure Structure
TM1 30 L 1.43x43 Structure Structure
TM1 31 V 1.44x44 Structure Structure
TM1 32 P 1.45x45 Structure Structure
TM1 33 G 1.46x46 Structure Structure
TM1 34 L 1.47x47 Structure Structure
TM1 35 I 1.48x48 Structure Structure
TM1 36 G 1.49x49 Structure Structure
TM1 37 N 1.50x50 Structure Structure
TM1 38 I 1.51x51 Structure Structure
TM1 39 L 1.52x52 Structure Structure
TM1 40 A 1.53x53 Structure Structure
TM1 41 L 1.54x54 Structure Structure
TM1 42 W 1.55x55 Structure Structure
TM1 43 V 1.56x56 Structure Structure
TM1 44 F 1.57x57 Structure Structure
TM1 45 Y 1.58x58 Structure Structure
TM1 46 G 1.59x59 Structure Structure
TM1 47 Y 1.60x60 Structure Structure
TM1 48 M 1.61x61 Structure Structure
TM1 49 K 1.62x62 Structure Structure
TM1 50 E 1.63x63 Structure Structure
TM1 51 T 1.64x64 Structure Structure
ICL1 52 K - Structure Structure
ICL1 53 R - Structure Structure
ICL1 54 A - Structure Structure
TM2 55 V 2.40x40 Structure Structure
TM2 56 I 2.41x41 Structure Structure
TM2 57 F 2.42x42 Structure Structure
TM2 58 M 2.43x43 Structure Structure
TM2 59 I 2.44x44 Structure Structure
TM2 60 N 2.45x45 Structure Structure
TM2 61 L 2.46x46 Structure Structure
TM2 62 A 2.47x47 Structure Structure
TM2 63 I 2.48x48 Structure Structure
TM2 64 A 2.49x49 Structure Structure
TM2 65 D 2.50x50 Structure Structure
TM2 66 L 2.51x51 Structure Structure
TM2 67 L 2.52x52 Structure Structure
TM2 68 Q 2.53x53 Structure Structure
TM2 69 V 2.54x54 Structure Structure
TM2 70 L 2.55x55 Structure Structure
TM2 71 S 2.56x56 Structure Structure
TM2 72 L 2.57x57 Structure Structure
TM2 73 P 2.58x58 Structure Structure
TM2 74 L 2.59x59 Structure Structure
TM2 75 R 2.60x60 Structure Structure
TM2 76 I 2.61x61 Structure Structure
TM2 77 F 2.62x62 Structure Structure
TM2 78 Y 2.63x63 Structure Structure
TM2 79 Y 2.64x64 Structure Structure
TM2 80 L 2.65x65 Structure Structure
TM2 81 N 2.66x66 Structure Structure
TM2 82 H 2.67x67 Structure Structure
ECL1 83 D 23.49x49 Structure Structure
ECL1 84 W 23.50x50 Structure Structure
ECL1 85 P 23.51x51 Structure Structure
ECL1 86 F 23.52x52 Structure Structure
TM3 87 G 3.21x21 Structure Structure
TM3 88 P 3.22x22 Structure Structure
TM3 89 G 3.23x23 Structure Structure
TM3 90 L 3.24x24 Structure Structure
TM3 91 C 3.25x25 Structure Structure
TM3 92 M 3.26x26 Structure Structure
TM3 93 F 3.27x27 Structure Structure
TM3 94 C 3.28x28 Structure Structure
TM3 95 F 3.29x29 Structure Structure
TM3 96 Y 3.30x30 Structure Structure
TM3 97 L 3.31x31 Structure Structure
TM3 98 K 3.32x32 Structure Structure
TM3 99 Y 3.33x33 Structure Structure
TM3 100 V 3.34x34 Structure Structure
TM3 101 N 3.35x35 Structure Structure
TM3 102 M 3.36x36 Structure Structure
TM3 103 Y 3.37x37 Structure Structure
TM3 104 A 3.38x38 Structure Structure
TM3 105 S 3.39x39 Structure Structure
TM3 106 I 3.40x40 Structure Structure
TM3 107 Y 3.41x41 Structure Structure
TM3 108 F 3.42x42 Structure Structure
TM3 109 L 3.43x43 Structure Structure
TM3 110 V 3.44x44 Structure Structure
TM3 111 C 3.45x45 Structure Structure
TM3 112 I 3.46x46 Structure Structure
TM3 113 S 3.47x47 Structure Structure
TM3 114 V 3.48x48 Structure Structure
TM3 115 R 3.49x49 Structure Structure
TM3 116 R 3.50x50 Structure Structure
TM3 117 F 3.51x51 Structure Structure
TM3 118 W 3.52x52 Structure Structure
TM3 119 F 3.53x53 Structure Structure
TM3 120 L 3.54x54 Structure Structure
TM3 121 M 3.55x55 Structure Structure
TM3 122 Y 3.56x56 Structure Structure
ICL2 123 P 34.50x50 Structure Structure
ICL2 124 F 34.51x51 Structure Structure
ICL2 125 R 34.52x52 Structure Structure
ICL2 126 F 34.53x53 Structure Structure
ICL2 127 H 34.54x54 Structure Structure
ICL2 128 D 34.55x55 Structure Structure
ICL2 129 C 34.56x56 Structure Structure
TM4 130 K 4.38x38 Structure Structure
TM4 131 Q 4.39x39 Structure Structure
TM4 132 K 4.40x40 Structure Structure
TM4 133 Y 4.41x41 Structure Structure
TM4 134 D 4.42x42 Structure Structure
TM4 135 L 4.43x43 Structure Structure
TM4 136 Y 4.44x44 Structure Structure
TM4 137 I 4.45x45 Structure Structure
TM4 138 S 4.46x46 Structure Structure
TM4 139 I 4.47x47 Structure Structure
TM4 140 A 4.48x48 Structure Structure
TM4 141 G 4.49x49 Structure Structure
TM4 142 W 4.50x50 Structure Structure
TM4 143 L 4.51x51 Structure Structure
TM4 144 I 4.52x52 Structure Structure
TM4 145 I 4.53x53 Structure Structure
TM4 146 C 4.54x54 Structure Structure
TM4 147 L 4.55x55 Structure Structure
TM4 148 A 4.56x56 Structure Structure
TM4 149 C 4.57x57 Structure Structure
TM4 150 V 4.58x58 Structure Structure
TM4 151 L 4.59x59 Structure Structure
TM4 152 F 4.60x60 Structure Structure
TM4 153 P 4.61x61 Structure Structure
TM4 154 L 4.62x62 Structure Structure
TM4 155 L 4.63x63 Structure Structure
TM4 156 R 4.64x64 Structure Structure
ECL2 157 T - Structure Structure
ECL2 158 S - Structure Structure
ECL2 159 D - Structure Structure
ECL2 160 D - Structure Structure
ECL2 161 T - Structure Structure
ECL2 162 S - Structure Structure
ECL2 163 G - Structure Structure
ECL2 164 N - Structure Structure
ECL2 165 R - Structure Structure
ECL2 166 T - Structure Structure
ECL2 167 K - Structure Structure
ECL2 168 C 45.50x50 Structure Structure
ECL2 169 F 45.51x51 Structure Structure
ECL2 170 V 45.52x52 Structure Structure
ECL2 171 D - Structure Structure
ECL2 172 L - Structure Structure
ECL2 173 P - Structure Structure
ECL2 174 T - Structure Structure
ECL2 175 R - Structure Structure
ECL2 176 N - Structure Structure
ECL2 177 V - Structure Structure
TM5 178 N 5.31x32 Structure Structure
TM5 179 L 5.32x33 Structure Structure
TM5 180 A 5.33x34 Structure Structure
TM5 181 Q 5.34x35 Structure Structure
TM5 182 S 5.35x36 Structure Structure
TM5 183 V 5.36x37 Structure Structure
TM5 184 V 5.37x38 Structure Structure
TM5 185 M 5.38x39 Structure Structure
TM5 186 M 5.39x40 Structure Structure
TM5 187 T 5.40x41 Structure Structure
TM5 188 I 5.41x42 Structure Structure
TM5 189 G 5.42x43 Structure Structure
TM5 190 E 5.43x44 Structure Structure
TM5 191 L 5.44x45 Structure Structure
TM5 192 I 5.45x46 Structure Structure
TM5 193 G 5.46x461 Structure Structure
TM5 194 F 5.47x47 Structure Structure
TM5 195 V 5.48x48 Structure Structure
TM5 196 T 5.49x49 Structure Structure
TM5 197 P 5.50x50 Structure Structure
TM5 198 L 5.51x51 Structure Structure
TM5 199 L 5.52x52 Structure Structure
TM5 200 I 5.53x53 Structure Structure
TM5 201 V 5.54x54 Structure Structure
TM5 202 L 5.55x55 Structure Structure
TM5 203 Y 5.56x56 Structure Structure
TM5 204 C 5.57x57 Structure Structure
TM5 205 T 5.58x58 Structure Structure
TM5 206 W 5.59x59 Structure Structure
TM5 207 K 5.60x60 Structure Structure
TM5 208 T 5.61x61 Structure Structure
TM5 209 V 5.62x62 Structure Structure
TM5 210 L 5.63x63 Structure Structure
TM5 211 S 5.64x64 Structure Structure
TM5 212 L 5.65x65 Structure Structure
ICL3 213 Q - Structure Structure
ICL3 214 D - Structure Structure
ICL3 215 K - Structure Structure
ICL3 216 Y - Structure Structure
ICL3 217 P - Structure Structure
ICL3 218 M - Structure Structure
ICL3 219 A - Structure Structure
ICL3 220 Q - Structure Structure
ICL3 221 D - Structure Structure
ICL3 222 L - Structure Structure
TM6 223 G 6.28x28 Structure Structure
TM6 224 E 6.29x29 Structure Structure
TM6 225 K 6.30x30 Structure Structure
TM6 226 Q 6.31x31 Structure Structure
TM6 227 K 6.32x32 Structure Structure
TM6 228 A 6.33x33 Structure Structure
TM6 229 L 6.34x34 Structure Structure
TM6 230 K 6.35x35 Structure Structure
TM6 231 M 6.36x36 Structure Structure
TM6 232 I 6.37x37 Structure Structure
TM6 233 L 6.38x38 Structure Structure
TM6 234 T 6.39x39 Structure Structure
TM6 235 C 6.40x40 Structure Structure
TM6 236 A 6.41x41 Structure Structure
TM6 237 G 6.42x42 Structure Structure
TM6 238 V 6.43x43 Structure Structure
TM6 239 F 6.44x44 Structure Structure
TM6 240 L 6.45x45 Structure Structure
TM6 241 I 6.46x46 Structure Structure
TM6 242 C 6.47x47 Structure Structure
TM6 243 F 6.48x48 Structure Structure
TM6 244 A 6.49x49 Structure Structure
TM6 245 P 6.50x50 Structure Structure
TM6 246 Y 6.51x51 Structure Structure
TM6 247 H 6.52x52 Structure Structure
TM6 248 F 6.53x53 Structure Structure
TM6 249 S 6.54x54 Structure Structure
TM6 250 F 6.55x55 Structure Structure
TM6 251 P 6.56x56 Structure Structure
TM6 252 L 6.57x57 Structure Structure
TM6 253 D 6.58x58 Structure Structure
TM6 254 F 6.59x59 Structure Structure
TM6 255 L 6.60x60 Structure Structure
TM6 256 V 6.61x61 Structure Structure
TM6 257 K 6.62x62 Structure Structure
TM6 258 S 6.63x63 Structure Structure
TM6 259 N 6.64x64 Structure Structure
ECL3 260 E - Structure Structure
ECL3 261 I - Structure Structure
ECL3 262 K - Structure Structure
TM7 263 S 7.24x23 Structure Structure
TM7 264 C 7.25x24 Structure Structure
TM7 265 L 7.26x25 Structure Structure
TM7 266 A 7.27x26 Structure Structure
TM7 267 R 7.28x27 Structure Structure
TM7 268 R 7.29x28 Structure Structure
TM7 269 V 7.30x29 Structure Structure
TM7 270 I 7.31x30 Structure Structure
TM7 271 L 7.32x31 Structure Structure
TM7 272 I 7.33x32 Structure Structure
TM7 273 F 7.34x33 Structure Structure
TM7 274 H 7.35x34 Structure Structure
TM7 275 S 7.36x35 Structure Structure
TM7 276 V 7.37x36 Structure Structure
TM7 277 A 7.38x37 Structure Structure
TM7 278 L 7.39x38 Structure Structure
TM7 279 C 7.40x39 Structure Structure
TM7 280 L 7.41x40 Structure Structure
TM7 281 A 7.42x41 Structure Structure
TM7 282 S 7.43x42 Structure Structure
TM7 283 L 7.44x43 Structure Structure
TM7 284 N 7.45x45 Structure Structure
TM7 285 S 7.46x46 Structure Structure
TM7 286 C 7.47x47 Structure Structure
TM7 287 L 7.48x48 Structure Structure
TM7 288 D 7.49x49 Structure Structure
TM7 289 P 7.50x50 Structure Structure
TM7 290 V 7.51x51 Structure Structure
TM7 291 I 7.52x52 Structure Structure
TM7 292 Y 7.53x53 Structure Structure
TM7 293 Y 7.54x54 Structure Structure
TM7 294 F 7.55x55 Structure Structure
TM7 295 S 7.56x56 Structure Structure
H8 296 T 8.47x47 Structure Structure
H8 297 N 8.48x48 Structure Structure
H8 298 E 8.49x49 Structure Structure
H8 299 F 8.50x50 Structure Structure
H8 300 R 8.51x51 Structure Structure
H8 301 R 8.52x52 Structure Structure
H8 302 R 8.53x53 Structure Structure
H8 303 L 8.54x54 Structure Structure
H8 304 S 8.55x55 AF2 AF2
H8 305 R 8.56x56 AF2 AF2
H8 306 Q 8.57x57 AF2 AF2
H8 307 D 8.58x58 AF2 AF2
H8 308 L 8.59x59 AF2 AF2
C-term 309 H - AF2 AF2
C-term 310 D - AF2 AF2
C-term 311 S - AF2 AF2
C-term 312 I - AF2 AF2
C-term 313 Q - AF2 AF2
C-term 314 L - AF2 AF2
C-term 315 H - AF2 AF2
C-term 316 A - AF2 AF2
C-term 317 K - AF2 AF2
C-term 318 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 M 218 - G.S6 Y 360 G.S6.02
Hydrophobic TM6 A 228 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM2 M 58 2x43 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 112 3x46 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 218 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 218 - G.H5 R 385 G.H5.17
Hydrophobic H8 F 299 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 F 299 8x50 G.H5 L 393 G.H5.25
Polar H8 N 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 297 8x48 G.H5 E 392 G.H5.24
Polar ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 Q 390 G.H5.22
Polar TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM1 F 44 1x57 G.H5 L 393 G.H5.25
Polar ICL1 R 53 - G.H5 Y 391 G.H5.23
Hydrophobic ICL1 R 53 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 R 53 - G.H5 Y 391 G.H5.23
Hydrophobic ICL3 Y 216 - G.S6 Y 360 G.S6.02
Ionic ICL3 D 221 - G.H5 R 385 G.H5.17
Polar ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 D 221 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic TM7 Y 293 7x54 G.H5 L 393 G.H5.25
Polar ICL3 L 222 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic H8 E 298 8x49 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 123 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 M 58 2x43 G.H5 L 393 G.H5.25
Polar ICL2 D 128 34x55 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 D 128 34x55 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 126 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 F 126 34x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 119 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 F 119 3x53 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 116 3x50 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 123 34x50 G.H5 R 380 G.H5.12
Polar TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 124 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 H 127 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 Q 220 - G.h4s6 T 350 G.h4s6.03
Hydrophobic H8 T 296 8x47 G.H5 L 393 G.H5.25
Aromatic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM2 V 55 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 V 55 2x40 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 124 34x51 G.H5 R 380 G.H5.12
Hydrophobic H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 120 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM1 Y 47 1x60 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Ionic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 225 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 225 6x30 G.H5 D 381 G.H5.13
Hydrophobic ICL2 F 124 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 C 129 34x56 G.hns1 R 38 G.hns1.02
Polar TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Polar ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Aromatic ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Polar ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Polar H8 E 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Polar ICL3 Q 220 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 220 - G.S6 C 359 G.S6.01
Polar ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM3 R 115 3x49 G.H5 L 394 G.H5.26
Ionic TM6 E 224 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 224 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 224 6x29 G.H5 R 385 G.H5.17