TSH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Aug. 3, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Glycoprotein hormones alpha chain - Agonist ,

Thyrotropin subunit beta - Agonist

PHYSIOLOGICAL LIGANDS

TSH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 523 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 523 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 625 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 625 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 527 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 527 - G.H5 F 376 G.H5.08
Polar TM6 R 625 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 625 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 625 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 529 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 529 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 608 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 608 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 526 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 526 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 523 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 M 527 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 527 - G.H5 R 380 G.H5.12
Hydrophobic TM6 M 626 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 607 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM6 K 621 6x32 G.H5 L 393 G.H5.25
Polar TM6 I 622 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 I 622 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 622 6x33 G.H5 L 393 G.H5.25
Aromatic TM3 R 519 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 519 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 519 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 622 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 622 6x33 G.H5 L 394 G.H5.26
Polar TM3 I 523 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 I 622 6x33 G.H5 L 388 G.H5.20
Hydrophobic H8 T 682 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 682 8x47 G.H5 E 392 G.H5.24
Polar H8 K 683 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 683 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 683 8x48 G.H5 E 392 G.H5.24