OX2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7L1V

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41467-021-21087-6

PUBLICATION DATE

Feb. 10, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

compound 1 [PMID: 33547286] - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

orexin-B, orexin-A



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 160 - G.H5 C 379 G.H5.11
Ionic TM6 R 299 6x30 G.H5 D 381 G.H5.13
Polar TM6 R 299 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 299 6x30 G.H5 L 384 G.H5.16
Hydrophobic TM6 T 302 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM4 T 165 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 T 165 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 162 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 162 - G.H5 I 383 G.H5.15
Hydrophobic TM6 L 306 6x37 G.H5 L 393 G.H5.25
Van-der-waals H8 K 370 8x49 G.H5 R 389 G.H5.21
Hydrophobic ICL2 F 162 - G.S1 L 41 G.S1.02
Polar TM3 A 155 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM5 L 250 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM6 T 302 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 302 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 160 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 160 - G.H5 F 376 G.H5.08
Van-der-waals TM6 R 299 6x30 G.H5 Q 385 G.H5.17
Hydrophobic TM5 L 250 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 Q 295 6x26 G.h4s6 I 358 G.h4s6.20
Van-der-waals TM6 Q 295 6x26 G.h4s6 I 358 G.h4s6.20
Polar H8 K 370 8x49 G.H5 N 392 G.H5.24
Hydrophobic H8 K 370 8x49 G.H5 N 392 G.H5.24
Van-der-waals H8 K 370 8x49 G.H5 N 392 G.H5.24
Polar ICL2 F 162 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 F 162 - G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 F 162 - G.hns1 R 39 G.hns1.03
Polar TM6 Q 295 6x26 G.H5 Q 385 G.H5.17
Hydrophobic TM3 I 156 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 159 - G.H5 K 380 G.H5.12
Polar ICL2 F 162 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 162 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 F 162 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 R 152 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 249 5x64 G.H5 L 384 G.H5.16
Van-der-waals TM5 K 249 5x64 G.H5 L 384 G.H5.16
Polar H8 S 368 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 S 368 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 160 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 L 160 - G.S3 V 217 G.S3.01
Polar TM3 D 151 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 151 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 151 3x49 G.H5 Y 391 G.H5.23
Polar ICL2 S 164 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 160 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 160 - G.H5 I 383 G.H5.15
Hydrophobic H8 K 370 8x49 G.H5 E 390 G.H5.22
Hydrophobic ICL2 P 159 - G.H5 L 384 G.H5.16
Hydrophobic ICL2 P 159 - G.H5 I 383 G.H5.15
Hydrophobic TM3 A 155 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 89 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 299 6x30 G.H5 L 388 G.H5.20