OX2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SQO

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-022-30601-3

PUBLICATION DATE

May 25, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate - Agonist pubchem

PHYSIOLOGICAL LIGANDS

orexin-B, orexin-A



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 159 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 159 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 162 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 162 - G.S3 L 194 G.S3.01
Hydrophobic TM2 T 89 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 249 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 249 5x64 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 159 - G.H5 N 347 G.H5.19
Hydrophobic TM2 T 89 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 89 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 159 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 159 - G.H5 I 344 G.H5.16
Hydrophobic TM3 I 156 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 156 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 160 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 160 - G.S3 L 194 G.S3.01
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Polar TM6 K 301 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 301 6x32 G.H5 L 353 G.H5.25
Polar TM3 A 155 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 301 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 301 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 160 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 160 - G.H5 F 336 G.H5.08
Hydrophobic H8 S 368 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 G 352 G.H5.24
Van-der-waals TM3 I 156 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 C 351 G.H5.23
Polar ICL2 M 161 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 161 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 305 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 305 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 306 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 306 6x37 G.H5 L 353 G.H5.25
Polar TM6 T 302 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 302 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 302 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 160 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 F 162 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 162 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 162 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 160 - G.H5 I 343 G.H5.15