NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Rattus norvegicus

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7L0S

RESOLUTION

4.5 Å

REFERENCE

10.1038/S41594-020-00554-6

PUBLICATION DATE

Jan. 6, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

52 interactions (Click to see)

LIGANDS

neurotensin - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

PHYSIOLOGICAL LIGANDS

neuromedin N, neurotensin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 I 295 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 I 295 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 R 299 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 299 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 I 295 - G.H5 D 337 G.H5.09
Hydrophobic TM6 L 303 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM5 M 267 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 267 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 302 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 I 295 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 I 295 - G.S6 Y 320 G.S6.02
Hydrophobic TM2 Q 99 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 99 2x36 G.H5 D 350 G.H5.22
Polar TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 106 2x43 G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 175 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 175 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 V 309 6x36 G.H5 L 353 G.H5.25
Aromatic ICL3 R 299 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 299 - G.H5 F 354 G.H5.26
Hydrophobic TM2 V 102 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 T 294 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 I 295 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 175 34x51 G.HN R 24 G.HN.48
Van-der-waals ICL2 F 175 34x51 G.HN R 24 G.HN.48
Hydrophobic ICL3 N 292 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 N 292 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 174 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 E 296 - G.H5 D 341 G.H5.13
Ionic ICL3 R 299 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 299 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 299 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 299 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 V 102 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 V 102 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM2 V 102 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 102 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 I 295 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 I 295 - G.H5 F 334 G.H5.06
Hydrophobic TM6 G 306 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 S 373 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 373 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 171 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 175 34x51 G.HN E 28 G.HN.52
Van-der-waals ICL2 F 175 34x51 G.HN E 28 G.HN.52
Hydrophobic ICL3 P 297 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 P 297 - G.h4s6 E 318 G.h4s6.12
Ionic ICL3 R 299 - G.H5 D 341 G.H5.13
Polar ICL3 R 299 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 175 34x51 G.HN G 27 G.HN.51
Van-der-waals ICL2 F 175 34x51 G.HN G 27 G.HN.51