Rhodopsin - Gt1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Bos taurus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 24, 2019

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Retinal (all-trans) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
A02R03G.hns1D02G.s2s3Y02G.S6D09K17N19K21C23G.H5GproteinR-N-K-Q-Q-V3x53R3x50T6x26GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.s2s3G.S6G.H5GPCR segments:ICL2TM3ICL3TM6ICL4

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x545x656x266x296x326x336x366x40G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.13G.H5.09G.S6.02G.h4s6.10G.s2s3.02G.hns1.03G.hns1.02Res. Pos.Rhodopsin (6OYA)- (6OYA)------------LRVVVTAEVMMLRVVVTAEVMMQDCLNILDKFDKGYVARD

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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