GPR20 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HSC

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41421-023-00520-8

PUBLICATION DATE

March 8, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 239 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 229 - G.H5 F 334 G.H5.06
Polar TM2 S 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 88 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 229 - G.H5 A 338 G.H5.10
Hydrophobic TM6 R 236 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 242 6x36 G.H5 L 353 G.H5.25
Polar TM2 S 88 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 88 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 88 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL2 R 154 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 152 3x54 G.H5 L 353 G.H5.25
Polar TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 353 G.H5.25
Polar ICL3 Q 231 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Q 231 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 231 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 228 - G.H5 I 344 G.H5.16
Hydrophobic TM3 I 152 3x54 G.H5 C 351 G.H5.23
Polar H8 S 302 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 302 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Polar ICL3 Q 231 - G.S6 I 319 G.S6.01
Hydrophobic TM6 G 232 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 225 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 225 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 229 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 229 - G.H5 D 337 G.H5.09
Hydrophobic TM6 R 235 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 235 6x29 G.H5 L 348 G.H5.20
Ionic TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Ionic TM6 R 236 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 235 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 R 236 6x30 G.H5 I 344 G.H5.16
Hydrophobic ICL3 Q 231 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Q 231 - G.S6 Y 320 G.S6.02
Ionic TM6 R 235 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 235 6x29 G.H5 D 341 G.H5.13
Polar TM3 A 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 347 G.H5.19
Aromatic TM6 R 235 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 235 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 F 354 G.H5.26