P2Y2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K20

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41421-025-00797-X

PUBLICATION DATE

June 11, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

42 interactions (Click to see)

LIGANDS

ATP - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

UTP, ATP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 143 34x55 G.S1 K 30 G.S1.01
Van-der-waals ICL2 R 143 34x55 G.S1 K 30 G.S1.01
Hydrophobic TM3 V 135 3x54 G.H5 L 220 G.H5.20
Hydrophobic ICL2 L 142 34x54 G.H5 N 219 G.H5.19
Van-der-waals ICL2 L 142 34x54 G.H5 N 219 G.H5.19
Hydrophobic ICL2 P 138 34x50 G.H5 I 216 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 I 216 G.H5.16
Hydrophobic TM6 K 240 6x31 G.H5 L 220 G.H5.20
Polar ICL2 P 138 34x50 G.H5 N 219 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 219 G.H5.19
Hydrophobic ICL2 P 138 34x50 G.H5 I 215 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 215 G.H5.15
Ionic TM6 K 240 6x31 G.H5 D 213 G.H5.13
Polar TM6 K 240 6x31 G.H5 D 213 G.H5.13
Hydrophobic TM6 K 240 6x31 G.H5 D 213 G.H5.13
Van-der-waals TM6 K 240 6x31 G.H5 D 213 G.H5.13
Hydrophobic TM5 L 225 5x65 G.H5 L 220 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 220 G.H5.20
Hydrophobic ICL2 R 143 34x55 G.S1 V 32 G.S1.03
Van-der-waals ICL2 R 143 34x55 G.S1 V 32 G.S1.03
Hydrophobic TM5 M 221 5x61 G.H5 L 225 G.H5.25
Van-der-waals TM5 M 221 5x61 G.H5 L 225 G.H5.25
Hydrophobic TM5 M 221 5x61 G.H5 L 220 G.H5.20
Hydrophobic TM6 S 243 6x34 G.H5 L 220 G.H5.20
Polar ICL2 R 143 34x55 G.hns1 A 29 G.hns1.03
Hydrophobic ICL2 L 142 34x54 G.H5 I 215 G.H5.15
Van-der-waals ICL2 L 142 34x54 G.H5 I 215 G.H5.15
Polar TM6 S 243 6x34 G.H5 L 225 G.H5.25
Hydrophobic ICL3 Y 230 - G.H5 V 206 G.H5.06
Hydrophobic ICL2 L 139 34x51 G.H5 I 215 G.H5.15
Polar TM3 G 134 3x53 G.H5 N 219 G.H5.19
Hydrophobic TM3 G 134 3x53 G.H5 N 219 G.H5.19
Van-der-waals TM3 G 134 3x53 G.H5 N 219 G.H5.19
Hydrophobic TM3 R 131 3x50 G.H5 L 225 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 225 G.H5.25
Hydrophobic TM6 A 239 6x30 G.H5 Y 226 G.H5.26
Van-der-waals TM6 A 239 6x30 G.H5 Y 226 G.H5.26
Hydrophobic ICL2 L 139 34x51 G.S3 L 77 G.S3.01
Van-der-waals ICL2 L 139 34x51 G.S3 L 77 G.S3.01
Hydrophobic TM3 H 130 3x49 G.H5 C 223 G.H5.23
Hydrophobic ICL3 A 229 - G.S6 Y 192 G.S6.02
Polar ICL3 G 231 - G.S6 C 193 G.S6.03
Van-der-waals ICL3 G 231 - G.S6 C 193 G.S6.03
Hydrophobic TM5 L 225 5x65 G.H5 I 216 G.H5.16
Polar ICL3 T 232 - G.h4s6 E 190 G.h4s6.12
Hydrophobic ICL3 T 232 - G.h4s6 E 190 G.h4s6.12
Van-der-waals ICL3 T 232 - G.h4s6 E 190 G.h4s6.12
Hydrophobic ICL2 L 139 34x51 G.H5 F 208 G.H5.08
Polar TM3 R 131 3x50 G.H5 C 223 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 223 G.H5.23
Ionic TM5 R 224 5x64 G.H5 D 213 G.H5.13
Hydrophobic TM7 L 308 7x55 G.H5 Y 226 G.H5.26
Van-der-waals TM7 L 308 7x55 G.H5 Y 226 G.H5.26
Polar TM3 R 131 3x50 G.H5 G 224 G.H5.24
Hydrophobic ICL3 G 231 - G.S6 Y 192 G.S6.02
Polar TM6 K 242 6x33 G.H5 Y 226 G.H5.26
Hydrophobic TM6 K 242 6x33 G.H5 Y 226 G.H5.26
Van-der-waals TM6 K 242 6x33 G.H5 Y 226 G.H5.26
Polar TM2 N 66 2x37 G.H5 G 222 G.H5.22
Polar ICL2 R 143 34x55 G.S1 D 31 G.S1.02
Van-der-waals ICL2 R 143 34x55 G.S1 D 31 G.S1.02
Van-der-waals ICL3 G 231 - G.S6 I 191 G.S6.01
Hydrophobic TM5 R 224 5x64 G.H5 I 216 G.H5.16
Van-der-waals TM5 R 224 5x64 G.H5 I 216 G.H5.16
Polar ICL3 Y 230 - G.S6 H 194 G.S6.04
Hydrophobic ICL3 Y 230 - G.S6 H 194 G.S6.04
Van-der-waals ICL3 Y 230 - G.S6 H 194 G.S6.04
Polar ICL3 S 233 - G.H4 E 181 G.H4.16
Hydrophobic ICL3 S 233 - G.H4 E 181 G.H4.16
Van-der-waals ICL3 S 233 - G.H4 E 181 G.H4.16
Polar TM6 R 245 6x36 G.H5 Y 226 G.H5.26
Van-der-waals TM6 R 245 6x36 G.H5 Y 226 G.H5.26
Hydrophobic ICL3 A 229 - G.H5 D 213 G.H5.13
Polar TM6 T 246 6x37 G.H5 L 225 G.H5.25
Hydrophobic TM6 T 246 6x37 G.H5 L 225 G.H5.25
Hydrophobic ICL2 R 143 34x55 G.S3 L 77 G.S3.01
Van-der-waals ICL2 R 143 34x55 G.S3 L 77 G.S3.01
Hydrophobic ICL2 P 138 34x50 G.H5 T 212 G.H5.12