PTH1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8FLR

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.STR.2023.04.002

PUBLICATION DATE

April 26, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

124 interactions (Click to see)

LIGANDS

PTHrP[1-36] - Agonist

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36), PTHrP, PTH, TIP39



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 385 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic H8 N 463 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 313 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 313 - G.H5 I 383 G.H5.15
Van-der-waals H8 N 463 8x47 G.H5 E 392 G.H5.24
Polar TM3 L 309 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 385 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 309 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 313 - G.H5 Q 384 G.H5.16
Polar TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 413 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 413 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 306 3x54 G.H5 L 393 G.H5.25
Aromatic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Polar H8 G 464 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 G 464 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 464 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 310 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL3 T 392 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 T 392 - G.H5 R 385 G.H5.17
Hydrophobic TM3 I 310 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 388 G.H5.20
Polar TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 309 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM7 Y 459 7x57 G.H5 Y 391 G.H5.23
Ionic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 388 5x64 G.H5 D 381 G.H5.13
Aromatic ICL2 F 314 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 314 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 314 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 314 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 376 G.H5.08
Polar TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 412 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 R 380 G.H5.12
Hydrophobic TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 314 - G.S3 V 217 G.S3.01
Hydrophobic TM2 H 223 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 388 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 388 5x64 G.H5 L 388 G.H5.20
Polar TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 385 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 385 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL3 T 392 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 405 6x37 G.H5 L 394 G.H5.26
Ionic TM5 E 391 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 391 5x67 G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 313 - G.H5 H 387 G.H5.19
Hydrophobic TM5 K 388 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 389 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 389 5x65 G.H5 L 394 G.H5.26