Refined structure (8KGK) of Gs - GPR61

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-07-12

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 229 from structure (58.1%), 165 from model (41.9%)
Residue sidechains - 198 from structure (50.3%), 196 from model (49.7%)

REFINED GPCR RESIDUES

Residue backbones - 256 from structure (72.7%), 96 from model (27.3%)
Residue sidechains - 232 from structure (65.9%), 120 from model (34.1%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
T03Y20G.h4s6R12Q16H19Q22E24L25G.H5GproteinV3x55L5x75Y3x53A6x33W-H5x72R8x48R8x51V3x54GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM3ICL3TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x543x5534x5034x515x585x615x645x655x685x695x715x725x755x766x326x336x367x568x478x488x498x51G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.11G.H5.08G.S6.02G.h4s6.20G.h4s6.09G.h4s6.04G.h4s6.03G.h4s6.02G.h4s6.01G.H4.17G.H4.16G.S3.03G.S3.01G.S1.02Res. Pos.GPR61 (8KGK_REFINED)- (8KGK_REFINED)-------------------------RYVVPMYMVAAAQHLPKAVLNRQRPMRYVVYMVAAAQHLPKAVLNRQRMRIQHFCHVFYQLLLRYYSTGLRERIA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.