GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7RA3

RESOLUTION

3.2 Å

REFERENCE

10.1073/PNAS.2116506119

PUBLICATION DATE

April 13, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

gastric inhibitory polypeptide (human) - Incretin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 324 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 324 5x64 G.H5 D 381 G.H5.13
Polar TM5 R 328 5x68 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 328 5x68 G.S6 C 359 G.S6.01
Polar TM6 R 338 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 338 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 338 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 173 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 244 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 349 6x48 G.H5 Y 391 G.H5.23
Polar TM6 R 338 6x37 G.H5 E 392 G.H5.24
Polar TM5 K 324 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM7 I 395 7x60 G.H5 E 392 G.H5.24
Polar TM3 V 246 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM3 V 246 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 246 3x59 G.H5 R 380 G.H5.12
Ionic TM4 E 253 4x40 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 E 253 4x40 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 321 5x61 G.H5 L 393 G.H5.25
Aromatic TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 328 5x68 G.H4 L 346 G.H4.16
Hydrophobic TM5 L 325 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 325 5x65 G.H5 L 394 G.H5.26
Polar TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Polar TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 321 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 321 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 245 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 245 3x58 G.H5 L 388 G.H5.20
Polar H8 N 396 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 396 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 396 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 321 5x61 G.H5 L 388 G.H5.20
Polar TM3 L 244 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 244 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 244 3x57 G.H5 H 387 G.H5.19
Polar TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Aromatic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 338 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 248 - G.S3 V 217 G.S3.01
Hydrophobic TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 240 3x53 G.H5 Y 391 G.H5.23