NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

March 25, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

NTS8–13 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM7 V 367 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 V 367 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals H8 S 368 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 297 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM6 H 300 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 300 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 259 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 259 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 263 5x65 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 263 5x65 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 178 34x55 G.HN E 28 G.HN.52
Hydrophobic TM7 V 367 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 V 367 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM6 Q 296 6x28 G.H5 F 354 G.H5.26
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 298 6x30 G.H5 L 348 G.H5.20