5-HT5A receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

July 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

methylergonovine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 R 139 3x50 G.H5 C 222 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 222 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 222 G.H5.23
Hydrophobic ICL2 M 147 - G.S3 L 76 G.S3.01
Hydrophobic TM6 M 286 6x36 G.H5 L 224 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 I 215 G.H5.16
Hydrophobic TM6 V 287 6x37 G.H5 L 224 G.H5.25
Ionic TM5 R 230 5x68 G.h4s6 E 189 G.h4s6.12
Polar TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 218 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM6 K 279 6x29 G.H5 Y 225 G.H5.26
Hydrophobic TM5 R 230 5x68 G.H5 A 216 G.H5.17
Hydrophobic TM6 A 283 6x33 G.H5 L 224 G.H5.25
Hydrophobic TM4 L 151 4x35 G.hns1 K 29 G.hns1.03
Polar TM5 V 231 5x69 G.H5 Y 225 G.H5.26
Van-der-waals TM5 V 231 5x69 G.H5 Y 225 G.H5.26
Hydrophobic TM6 M 286 6x36 G.H5 G 223 G.H5.24
Ionic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic TM3 I 143 3x54 G.H5 L 219 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 219 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 N 218 G.H5.19
Van-der-waals TM3 I 143 3x54 G.H5 N 218 G.H5.19
Hydrophobic ICL2 P 146 - G.H5 I 214 G.H5.15
Hydrophobic TM5 A 227 5x65 G.H5 L 224 G.H5.25
Hydrophobic ICL2 M 147 - G.H5 T 211 G.H5.12
Hydrophobic TM5 I 223 5x61 G.H5 L 224 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 224 G.H5.25
Hydrophobic ICL2 M 147 - G.H5 I 214 G.H5.15
Van-der-waals ICL2 M 147 - G.H5 I 214 G.H5.15
Hydrophobic TM5 R 230 5x68 G.H5 I 215 G.H5.16
Hydrophobic ICL2 P 146 - G.H5 I 215 G.H5.16
Van-der-waals ICL2 P 146 - G.H5 I 215 G.H5.16