apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W0P

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41594-022-00797-5

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

apelin receptor early endogenous ligand - Agonist pubchem

PHYSIOLOGICAL LIGANDS

apelin-36, apelin-17, apelin-13, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, [Pyr1]apelin-13, apelin receptor early endogenous ligand



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 134 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 131 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 131 3x54 G.H5 C 351 G.H5.23
Polar TM6 R 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 245 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 139 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 139 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 D 313 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 D 313 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 L 142 4x38 G.HN E 28 G.HN.52
Polar TM5 H 231 5x68 G.H5 T 340 G.H5.12
Polar TM6 R 245 6x32 G.H5 L 353 G.H5.25
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL4 F 312 - G.H5 F 354 G.H5.26
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Ionic ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Polar ICL1 S 63 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 S 63 - G.H5 D 350 G.H5.22
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 P 134 - G.H5 N 347 G.H5.19
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 I 344 G.H5.16
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 131 3x54 G.H5 N 347 G.H5.19
Ionic ICL1 R 62 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 62 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 62 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 134 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 - G.H5 I 344 G.H5.16
Hydrophobic ICL1 S 63 - G.H5 C 351 G.H5.23
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 313 8x47 G.H5 G 352 G.H5.24
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20