5-HT7 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XTC

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.MOLCEL.2022.05.031

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

42 interactions (Click to see)

LIGANDS

5-CT - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 278 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 278 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 L 188 34x51 G.S1 H 41 G.S1.02
Van-der-waals TM3 R 186 3x56 G.H5 R 380 G.H5.12
Polar TM5 S 269 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 269 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 188 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 188 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 S 269 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 191 34x54 G.H5 H 387 G.H5.19
Polar H8 R 389 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 R 389 8x48 G.H5 L 394 G.H5.26
Polar TM5 H 273 5x72 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 H 273 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 H 273 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 H 273 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 F 275 - G.h4s6 Y 358 G.h4s6.20
Polar H8 R 389 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 389 8x48 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 187 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 187 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL3 F 275 - G.S6 P 361 G.S6.03
Hydrophobic TM3 I 184 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM7 F 387 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 387 7x56 G.H5 E 392 G.H5.24
Polar ICL3 F 278 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 F 278 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 L 188 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 188 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 P 279 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 P 279 - G.H4 R 347 G.H4.17
Polar TM5 K 272 5x71 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 188 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 L 188 34x51 G.H5 C 379 G.H5.11
Polar TM6 K 324 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 324 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 324 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 188 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 L 188 34x51 G.S3 F 219 G.S3.03
Ionic H8 R 392 8x51 G.H5 E 392 G.H5.24
Hydrophobic ICL3 F 275 - G.H4 L 346 G.H4.16
Polar TM6 K 324 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 324 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL3 P 276 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM3 I 184 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 184 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 262 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 262 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 187 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 187 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 K 324 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 324 6x32 G.H5 L 393 G.H5.25
Polar TM6 T 328 6x36 G.H5 E 392 G.H5.24
Ionic H8 R 389 8x48 G.H5 E 392 G.H5.24
Polar H8 R 389 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 389 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 389 8x48 G.H5 E 392 G.H5.24
Polar TM5 H 273 5x72 G.H5 R 385 G.H5.17
Aromatic TM5 H 273 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 273 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 273 5x72 G.H5 R 385 G.H5.17
Ionic TM5 K 272 5x71 G.H5 D 381 G.H5.13
Polar TM5 K 272 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 272 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 272 5x71 G.H5 D 381 G.H5.13
Polar TM3 G 183 3x53 G.H5 H 387 G.H5.19
Polar TM6 A 325 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 325 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 325 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 187 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 187 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 187 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 187 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 184 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 184 3x54 G.H5 L 388 G.H5.20
Polar TM3 I 184 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 184 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 184 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 Q 194 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Q 194 34x57 G.hns1 R 38 G.hns1.02
Aromatic TM3 R 180 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 180 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 192 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 V 192 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 184 3x54 G.H5 L 393 G.H5.25
Polar ICL2 V 192 34x55 G.hns1 R 38 G.hns1.02
Polar H8 R 389 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 389 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 389 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL2 L 188 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 188 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 266 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 266 5x65 G.H5 L 388 G.H5.20
Polar ICL2 P 191 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 191 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 H 273 5x72 G.S6 Y 360 G.S6.02
Van-der-waals TM5 H 273 5x72 G.S6 Y 360 G.S6.02
Ionic TM5 H 273 5x72 G.H5 D 381 G.H5.13
Polar TM5 H 273 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 273 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 273 5x72 G.H5 D 381 G.H5.13
Polar TM3 T 185 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 185 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 266 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 266 5x65 G.H5 L 393 G.H5.25