Structure information

5-HT7 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XTC

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.05.031

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-CT D162 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-CT V163 3.33x33 TM3 polar (hydrogen bond)
5-CT V163 3.33x33 TM3 polar (hydrogen bond with backbone)
5-CT C166 3.36x36 TM3 polar (hydrogen bond)
5-CT T167 3.37x37 TM3 polar (hydrogen bond)
5-CT I213 4.56x56 TM4 Van der Waals
5-CT I233 45.52x52 ECL2 polar (hydrogen bond)
5-CT T240 5.39x40 TM5 polar (hydrogen bond)
5-CT T240 5.39x40 TM5 polar (hydrogen bond with backbone)
5-CT S243 5.42x43 TM5 polar (hydrogen bond)
5-CT S243 5.42x43 TM5 polar (hydrogen bond)
5-CT S243 5.42x43 TM5 polar (hydrogen bond with backbone)
5-CT T244 5.43x44 TM5 Van der Waals
5-CT T244 5.43x44 TM5 polar (hydrogen bond with backbone)
5-CT A247 5.46x461 TM5 polar (hydrogen bond)
5-CT W340 6.48x48 TM6 Van der Waals
5-CT F343 6.51x51 TM6 polar (hydrogen bond)
5-CT F344 6.52x52 TM6 aromatic (edge-to-face)
5-CT F344 6.52x52 TM6 polar (hydrogen bond)
5-CT S347 6.55x55 TM6 polar (hydrogen bond)
5-CT L370 7.39x38 TM7 polar (hydrogen bond)
5-CT Y374 7.43x42 TM7 Van der Waals

Ligands

5-CT

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Residue Diagrams

C N G A I T L L T I L T L I S G I V V K 1 V S L A L A D L S V A A V V M P F V S V T 2 V C L T M I S A T C C M V D M A I F V N 3 M A K M I L S V W L L S A S I T L P P L 4 Y M F L M V S M P I Y F A V A T S Y I T Y 5 G I I V G A F T V C W L P F F L L S T A 6 F P N I L S N A Y G L W L F T R E V W 7
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ICL1 K K L R ICL1ECL1 K W I F ECL1ICL2 P L T Y P V R Q ICL2ECL2 W A Q N V N D D K V C L I S Q ECL2ICL3 F P R V E P D S V I A L N G I V K L Q K E V E E C A N L S R L L K H E R K N ICL3ECL3 C G T S C S C I ECL3N-term M M D V N S S G R P D L Y G H L R S F L L P E V G R G L P D L S P D G G A D P V A G S W A P H L L S E V T A S P A P T W D A P P D N A S G C G E Q I N Y N-termC-term R N I N R K L S A A G M H E A L K L A E R P E R P E F V L R A C T R R V L L R P E K R P P V S V W V L Q S P D H H N W L A D K M L T T V E K K V M I H D C-term G R V E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R N G K C M A K M I L S V W L L S A S I T L P P L F G D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F P G I S I F K R E Q K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I P L W V E R T F L W L G Y A N S L I N P F I Y A F F N R D Y R S Q Y L R T T L L Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT7 receptor
TM3
3x32 3.32x32 D162
3x33 3.33x33 V163
3x36 3.36x36 C166
3x37 3.37x37 T167
TM4
4x56 4.56x56 I213
ECL2
45x52 45.52x52 I233
TM5
5x40 5.39x40 T240
5x43 5.42x43 S243
5x44 5.43x44 T244
5x461 5.46x461 A247
TM6
6x48 6.48x48 W340
6x51 6.51x51 F343
6x52 6.52x52 F344
6x55 6.55x55 S347
TM7
7x38 7.39x38 L370
7x42 7.43x42 Y374